Automated enzymatic hydrolysis of urine samples for improved systematic toxicological analysis of drug ‐facilitated sexual assault cases
Development and validation of an UHPLC-MS/MS screening method covering 144 drugs and metabolites relevant to drug-faciliated sexual assaults. The method included an automated enzymatic hydrolysis for an improved systemtatic toxicological analysis of DFSA cases. AbstractDrug-facilitated sexual assault (DFSA) is characterized by victim incapacitation due to intoxicating substances. Detection of single drug exposure from DFSA requires a systematic toxicological analysis strategy including sensitive methods covering a broad spectrum of substances. The aim of this study was to develop and validate an UHPLC –MS/MS screening me...
Source: Drug Testing and Analysis - January 24, 2024 Category: Drugs & Pharmacology Authors: Kathrine Skov,
Sys Stybe Johansen,
Kristian Linnet,
Marie Katrine Klose Nielsen Tags: RESEARCH ARTICLE Source Type: research
Characterization of DNA concentration in urine and dried blood samples to detect the c.577 deletion within the EPO gene
In conclusion, method for detection of EPO gene variant was developed in urine and DBS. Characterization of DNA concentration was performed in order to evaluate the probability of success of sequencing EPO gene in anti-doping field. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - January 22, 2024 Category: Drugs & Pharmacology Authors: Nicolas Leuenberger,
Nicolas Jan,
Tiia Kuuranne,
Vincent Castella Tags: RESEARCH ARTICLE Source Type: research
Hair analysis in postmortem investigations: Case of a skeletonized body
The interpretation of hair concentrations in skeletonized bodies presents some pitfalls due to contamination by the environment and by body fluids. The use of complementary matrices (nails, bone marrow, clothing) gives additional information. AbstractAnalysis of hair collected from putrefied or skeletal bodies is always complex and must take into account several pitfalls, such as external contamination and contamination by biological fluids. This work presents a case of particular complexity. A skeletonized body was discovered on a country road. A tuft of brown hair, detached from the scalp, irregular in length, non-orient...
Source: Drug Testing and Analysis - January 20, 2024 Category: Drugs & Pharmacology Authors: Anne ‐Laure Pelissier‐Alicot,
Alice Ameline,
Pascal Kintz,
Pascal Adalian,
Georges Leonetti Tags: LETTER TO THE EDITOR Source Type: research
Detection of methandienone and its metabolites in equine urine, plasma and hair following a multidose oral administration
Metabolism and detection of methandienone in urine are well established in horses, but there is limited knowledge about its metabolites in plasma and no information about its detection in hair. Following an oral administration, nine Phase I metabolites were observed in plasma, and the longest detection time was achieved by targeting the parent compound and the mono-hydroxylated metabolite. In hair, the parent compound and hydroxylated metabolites were detected and the mono-hydroxylated offered the longest detection time. AbstractMethandienone is an anabolic-androgenic steroid that is prohibited in equine sports due to its ...
Source: Drug Testing and Analysis - January 18, 2024 Category: Drugs & Pharmacology Authors: Marjaana Viljanto,
Catherine Love,
Daniel White,
Jocelyn Habershon ‐Butcher,
Pamela Hincks,
Bobby Gray,
James Scarth Tags: RESEARCH ARTICLE Source Type: research
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(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - January 17, 2024 Category: Drugs & Pharmacology Tags: COVER PICTURE Source Type: research
Issue Information
No abstract is available for this article. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - January 17, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
A systematic review of analytical methodologies capable of analysing phytocannabinoids in cosmetics
A Systematic review on available analytical methods capable of analysing cannabinoids in cosmetics was conducted. The results show that cosmetics remain a challenging matrix to obtain good recoveries and accuracies AbstractAs cannabidiol (CBD) is not considered to be a drug and because of its potential health claims, it is an interesting compound that is often found in cosmetics. However, the safety of CBD, as well as the presence of trace amounts of other phytocannabinoids, including the psychoactive substance ∆9-tetrahydrocannabinol (THC), is still being debated. A robust analytical technique capable of analysing cosme...
Source: Drug Testing and Analysis - January 17, 2024 Category: Drugs & Pharmacology Authors: Bart Desmedt,
Peter Van Campenhout,
Eric Deconinck Tags: MINI REVIEW Source Type: research
ICH Q14 ‐inspired novel approach to establish an SFC‐based purity method for carbamazepine
Analytical quality by design (AQbD) principles as described in the proposed ICH Q14 guideline were used to develop a supercritical fluid chromatography (SFC)-based purity method for carbamazepine. The resulting method is an alternative to the official HPLC method published in the Ph.Eur. with improved peak resolution, improved peak symmetry, and much faster analysis times (3 min vs. 80 min for the official method). AbstractThe proposed ICH Q14 guideline “Analytical procedure development” describes science and risk-based approaches for development and maintenance of analytical procedures suitable for the assessment of t...
Source: Drug Testing and Analysis - January 16, 2024 Category: Drugs & Pharmacology Authors: Alexander H. Schmidt,
Mijo Stanic,
Maria Kristina Parr Tags: RESEARCH ARTICLE Source Type: research
