Evaluation of sulfate metabolites as markers of topical testosterone administration in Caucasian and Asian populations
Sulfate metabolites of endogenous anabolic androgenic steroids have been evaluated for the detection of the topical administration of testosterone. Sensitivity was similar to or better than the conventional testosterone/epitestosterone ratio (T/E) of the steroid profile. AbstractSulfate metabolites of endogenous anabolic androgenic steroids (EAAS) have been shown to prolong the detection times compared with the conventional urinary markers of the steroid profile for oral and intramuscular administrations of testosterone (T). In this work, the sensitivity of sulfate EAAS markers for the detection of T gel administration has...
Source: Drug Testing and Analysis - November 28, 2023 Category: Drugs & Pharmacology Authors: Claudia Bressan, Élida Alechaga,
Nuria Monfort,
Rosa Ventura Tags: RESEARCH ARTICLE Source Type: research
Quantitative analysis of drugs of abuse and cognitive enhancers in influent wastewater by means of two chromatographic methods
Two methods for qualitative and quantitative analysis of selected drugs of abuse and a cognitive enhancer in wastewater samples were successfully developed and validated. A two-column setup was necessary for the analysis of all analytes included in this method. Evaluation of proof-of-concept samples enabled quantification of several analytes in wastewater grab samples, allowing the method to be used for monitoring trends in the consumption of the included analytes in wastewater. AbstractSewage-based epidemiology using influent wastewater is used to estimate the consumption trends of (illicit) drugs over a short or long per...
Source: Drug Testing and Analysis - November 28, 2023 Category: Drugs & Pharmacology Authors: Fabian Frankenfeld,
Lea Wagmann,
Cathy M. Jacobs,
Markus R. Meyer Tags: RESEARCH ARTICLE Source Type: research
Geographical classification of opium samples from Myanmar and Afghanistan by NMR profiling and chemometrics
This study presents a new strategy to discriminate between opium samples obtained from different geographical regions. Nuclear magnetic resonance (NMR) profiling and chemometrics were applied to geographical classification of opium originating from Myanmar and Afghanistan, which are two major opium producing countries in the world. A total of 50 Myanmar and 46 Afghanistan authentic opium samples were analyzed by1H-NMR, and the chemical profiles were characterized. Different sample preparation procedures, data processing methods, and chemometrics were compared to obtain the best classification effect. It was found that dryi...
Source: Drug Testing and Analysis - November 24, 2023 Category: Drugs & Pharmacology Authors: Cui ‐Mei Liu,
Wei Jia,
Xue‐Yan Liu,
Yu Du,
Zhen‐Dong Hua Tags: SHORT COMMUNICATION Source Type: research
Design of smart nanoparticles for the electrochemical detection of 3,4 ‐methylenedioxymethamphetamine to allow in field screening by law enforcement officers
A highly sensitive and portable sensor has been developed to detect MDMA in street samples. It uses electroactive molecularly imprinted polymer nanoparticles computationally designed to recognize MDMA, which were immobilized on screen-printed carbon electrodes with chitosan and graphene. The sensor showed good sensitivity and satisfactory recoveries (92 –99%), confirmed with UPLC-MS/MS validation. This technology has the potential to be used in forensic analysis. AbstractA portable and highly sensitive sensor was designed for the specific detection of 3,4-methyl-enedioxy-methamphetamine (MDMA), in a range of field-testin...
Source: Drug Testing and Analysis - November 23, 2023 Category: Drugs & Pharmacology Authors: Florina Maria Truta,
Alvaro Garcia Cruz,
Ana ‐Maria Dragan,
Mihaela Tertis,
Todd Cowen,
Maria‐Geogia Stefan,
Tamara Topala,
Amorn Slosse,
Elena Piletska,
Filip Van Durme,
Bela Kiss,
Karolien De Wael,
Sergey A. Piletsky,
Cecilia Cristea Tags: RESEARCH ARTICLE Source Type: research
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport
Twenty (4 %) of male urine samples (n = 542) from Drug Abuser Laboratory were positive for SARMs, whereas none of the analyzed female samples (n = 100) contained SARMs. The top three SARMs found were LGD-4033 followed by RAD140 and ostarine. Thirty-four percent and 7% of the male and female samples, respectively, were suspicious/positive for AAS. AbstractSelective androgen receptor modulators (SARMs) are prohibited by the World Anti-Doping Agency (WADA) since 2008. Similarly, to anabolic androgenic steroids (AAS), SARMs are detrimental to health not only in athletes but also in the general population. However, studies of t...
Source: Drug Testing and Analysis - November 21, 2023 Category: Drugs & Pharmacology Authors: Kim Petterson Bohlin,
Anton Pohanka,
Alexander Andersson,
Tomas Vill én,
Lena Ekström Tags: RESEARCH ARTICLE Source Type: research
A multivariable analysis delineating hair color, hair dyeing, and hat wearing as predictors of level of cocaine and MDMA detection in human hair samples
This study demonstrates the importance of using multivariable models to delineate predictors of drug detection. AbstractResearch suggests that hair color, hair dyeing, and perspiration can bias hair test results regarding drug exposure, but research is needed to examine such associations in a multivariable manner. In this epidemiology study, adults were surveyed entering nightclubs and dance festivals in New York City, and 328 provided hair samples, which were analyzed using ultra-high-performance liquid chromatography –tandem mass spectrometry to determine the level of detection of cocaine and 3,4-methylenedioxymethamph...
Source: Drug Testing and Analysis - November 21, 2023 Category: Drugs & Pharmacology Authors: Joseph J. Palamar,
Charles M. Cleland,
Marco Vincenti,
Alberto Salomone Tags: RESEARCH ARTICLE Source Type: research
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport
Twenty (4 %) of male urine samples (n = 542) from Drug Abuser Laboratory were positive for SARMs, whereas none of the analyzed female samples (n = 100) contained SARMs. The top three SARMs found were LGD-4033 followed by RAD140 and ostarine. Thirty-four percent and 7% of the male and female samples, respectively, were suspicious/positive for AAS. AbstractSelective androgen receptor modulators (SARMs) are prohibited by the World Anti-Doping Agency (WADA) since 2008. Similarly, to anabolic androgenic steroids (AAS), SARMs are detrimental to health not only in athletes but also in the general population. However, studies of t...
Source: Drug Testing and Analysis - November 21, 2023 Category: Drugs & Pharmacology Authors: Kim Petterson Bohlin,
Anton Pohanka,
Alexander Andersson,
Tomas Vill én,
Lena Ekström Tags: RESEARCH ARTICLE Source Type: research
A multivariable analysis delineating hair color, hair dyeing, and hat wearing as predictors of level of cocaine and MDMA detection in human hair samples
This study demonstrates the importance of using multivariable models to delineate predictors of drug detection. AbstractResearch suggests that hair color, hair dyeing, and perspiration can bias hair test results regarding drug exposure, but research is needed to examine such associations in a multivariable manner. In this epidemiology study, adults were surveyed entering nightclubs and dance festivals in New York City, and 328 provided hair samples, which were analyzed using ultra-high-performance liquid chromatography –tandem mass spectrometry to determine the level of detection of cocaine and 3,4-methylenedioxymethamph...
Source: Drug Testing and Analysis - November 21, 2023 Category: Drugs & Pharmacology Authors: Joseph J. Palamar,
Charles M. Cleland,
Marco Vincenti,
Alberto Salomone Tags: RESEARCH ARTICLE Source Type: research
An enhanced label ‐free proteomics approach for deep‐diving into equine plasma proteome, including the discovery of protein biomarkers for strenuous exercise
This study has refined the method for label-free profiling of the equine plasma proteome. After evaluation of various approaches, tandem fractionations of equine plasma with octanoic acid precipitation followed by solid-phase extraction (SPE) with C4 cartridges and the use of two narrower precursor mass ranges of m/z 400 –600 and 600–800 provided the largest increase in the number of new proteins identified. The enhanced method has enabled a deeper profiling of the equine plasma proteome to facilitate biomarker research. AbstractPlasma proteins have been a valuable source of biomarkers for clinical uses and for monitor...
Source: Drug Testing and Analysis - November 21, 2023 Category: Drugs & Pharmacology Authors: Hiu Wing Cheung,
Kin ‐Sing Wong,
Ning Sum To,
Terence S. M. Wan,
Emmie N. M. Ho Tags: RESEARCH ARTICLE Source Type: research
Application of micro capillary blood sampling in an anti ‐doping setting
Micro-capillary whole blood samples were collected in an authentic anti-doping setting prior to competition, demonstrating excellent agreement with venous blood samples for ABP parameters. Micro-volumetric capillary blood collection provides a promising alternative to venous blood collection for ABP purposes with the advantage of providing a more athlete-friendly experience, particularly close to competition. AbstractBlood collection is an important facet of anti-doping testing, forming the basis of the Athlete Biological Passport (ABP). Traditional blood collection via venipuncture can be uncomfortable for athletes, espec...
Source: Drug Testing and Analysis - November 21, 2023 Category: Drugs & Pharmacology Authors: Laura Lewis,
Jenna Goodrum,
Calvin Cai,
Tessa Muir,
Kristin Boutard,
Thomas Capdevielle,
Stefano Longo,
Matthew Fedoruk,
Geoff Miller Tags: SHORT COMMUNICATION Source Type: research
