Be aware of (R) ‐methamphetamine: Negative immunoassay versus positive confirmation analysis
We report two cases with proven enantiopure (R)-methamphetamine consumption with moreover both cases remaining undetected by immunoassay screening. Inconspicuous immunoassay findings can be traced back to a considerably higher sensitivity of the applied drug of abuse assay for the (S)-enantiomer of methamphetamine compared with the (R)-enantiomer - a limitation that should be well known by users of immunoassay drug tests. AbstractThe amphetamine-type stimulant methamphetamine exists in two enantiomeric forms, (S)-methamphetamine and (R)-methamphetamine, which are both psychoactive but with the (S)-enantiomer being more pot...
Source: Drug Testing and Analysis - July 28, 2023 Category: Drugs & Pharmacology Authors: Jennifer Liut,
Burkhard Madea,
Michael Kr ämer,
Alexandra Maas‐Gramlich Tags: SHORT COMMUNICATION Source Type: research
In vitro cannabinoid receptor activity, metabolism, and detection in seized samples of CH ‐PIATA, a new indole‐3‐acetamide synthetic cannabinoid
This study describes detections in 2022 of this new SCRA in the United States, Belgium, and Scottish prisons. CH-PIATA was detected once in a seized powder by Belgian customs and 12 times in Scottish prisons in infused papers or resin. The metabolites of CH-PIATA were investigated via in vitro human liver microsome (HLM) incubations and eight metabolites were identified, dominated by oxidative biotransformations. A blood sample from the United States was confirmed to contain a mixture of SCRAs including CH-PIATA via presence of the parent and at least five of the metabolites identified from HLM incubations. Furthermore, th...
Source: Drug Testing and Analysis - July 26, 2023 Category: Drugs & Pharmacology Authors: Caitlyn Norman,
Marie H. Deventer,
Olivia Dremann,
Robert Reid,
Katleen Van Uytfanghe,
Claude Guillou,
Inge M. J. Vinckier,
Niamh Nic Da éid,
Alex Krotulski,
Christophe P. Stove Tags: RESEARCH ARTICLE Source Type: research
Improved separation of fentanyl isomers using metal cation adducts and high ‐resolution ion mobility‐mass spectrometry
This study aimed to develop a rapid method for detecting and separating fentanyl isomers based on ion mobility –mass spectrometry (IM-MS), where IM separates gas-phase ions based on differences in their size, shape, and charge. Several strategies for improved differentiation were implemented, including using unconventional cation adducts (e.g., alkali and transition metals) and data post-processing by high -resolution demultiplexing. A collection of collision cross section (CCS) values for the various metal ion adducts was gathered, which can be used to improve confidence of identification in future samples. Notable exam...
Source: Drug Testing and Analysis - July 26, 2023 Category: Drugs & Pharmacology Authors: Ralph Aderorho,
Christopher D. Chouinard Tags: RESEARCH ARTICLE Source Type: research
