Routine application of SFC ‐MS in doping control: Analysis of 3 × 1000 urine samples using three different SFC‐MS instruments
We describe the analysis of almost 3000 anti-doping samples using SFC-MS instruments from Agilent Technologies, Waters Corporation and Shimadzu Corporation. This work successfully demonstrated the SFC-MS sensitivity, robustness and its readiness to be used in World Anti-Doping Agency accredited laboratories. AbstractSupercritical fluid chromatography-mass spectrometry (SFC-MS) has proved to be a beneficial tool for sample analysis for a wide variety of compounds and, as such, has recently gained the attention of the anti-doping community. We have tested the applicability of SFC-MS for routine doping control analysing appro...
Source: Drug Testing and Analysis - February 16, 2024 Category: Drugs & Pharmacology Authors: Ivana Gavrilovi ć,
Bernhard Wüst,
Jonathan Danaceau,
Emmanuelle Braidman,
Xavier de la Torre,
Francesco Botrè,
Maria Kristina Parr,
David Cowan Tags: RESEARCH ARTICLE Source Type: research
Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography ‐time‐of‐flight analysis
AbstractNew psychoactive substances are produced and marketed to mimic the effects of their illicit counterparts and to attempt to evade drug tests and prosecution. Here, we present the optimisation, validation and application of an analytical method using liquid chromatography –time-of-flight mass spectrometry to detect and quantify 37 new psychoactive substances and illicit substances in wastewater from South Wales, UK, using a targeted analysis method. Sample preparation was performed using solid-phase extraction with Oasis HLB cartridges. The LC separation was perfor med using a YMC-Triart Phenyl 450 bar column (12...
Source: Drug Testing and Analysis - February 16, 2024 Category: Drugs & Pharmacology Authors: Bethan Davies,
Richard Paul,
David Osselton,
Richard Evers,
Timothy Woolley Tags: APPLICATION NOTE Source Type: research
Interest of hair tests to discriminate a tail end of a doping regimen from a meat contamination in case of challenging an antidoping rule violation. III. Case report involving boldenone
(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - February 15, 2024 Category: Drugs & Pharmacology Authors: Pascal Kintz,
Laurie Gheddar Tags: LETTER TO THE EDITOR Source Type: research
ADB ‐HEXINACA—a novel synthetic cannabinoid with a hexyl substituent: phase I metabolism in authentic urine samples, a case report and prevalence on the German market
A new synthetic cannabinoid receptor agonist, ADB-HEXINACA, contains a hexyl-substituted tail on the indazole core. Here, we suggest urinary biomarkers as proof of its consumption after in vivo and in vitro analysis of phase I metabolism. ADB-HEXINACA could be encountered in fatal cases and shows alternating prevalence in German forensic samples. AbstractSynthetic cannabinoid receptor agonists (SCRAs) are one of the largest groups of new psychoactive substances (NPS). Yet, another novel analog started spreading on the NPS market around 2021. Soon after, the substance could be analytically characterized in herbal material a...
Source: Drug Testing and Analysis - February 14, 2024 Category: Drugs & Pharmacology Authors: Arianna Giorgetti,
Annette Zschiesche,
Olwen Groth,
Belal Haschimi,
Martin Scheu,
Guido Pelletti,
Paolo Fais,
Frank Musshoff,
Volker Auw ärter Tags: RESEARCH ARTICLE Source Type: research
Prevalence of nandrolone preparations with endogenous carbon isotope ratios in Australia
There is a high prevalence of nandrolone-containing anabolic androgenic steroid preparations in Australia that have ‘endogenous’ carbon isotope ratios. AbstractNandrolone and its prohormones, including 19-norandrost-4-ene-3,17-dione and 19-norandrost-4-ene-3 β,17β-diol, are anabolic steroids forbidden at all times in sports according to the World Anti-Doping Code Prohibited List and its metabolite 19-norandrosterone (19NA) is the preferred urinary target compound to identify their abuse. In recent years, an increasing number of 19NA isotope ratio mass spectrometry (IRMS) cases have arisen that, based on the initial t...
Source: Drug Testing and Analysis - February 12, 2024 Category: Drugs & Pharmacology Authors: Michael Polet,
Peter Van Eenoo,
Lance Brooker,
Claire Edey,
Vanessa Agon,
Janelle Grainger,
Gemma Payne,
Catrin Goebel Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature
Ambient ionization mass spectrometry enables the rapid, real-time analysis of samples in their native state. This review highlights recent developments in the use of ambient ionization for drugs analysis across various fields, including forensics, anti-doping, food safety, pharmaceuticals, environmental sciences, and diagnostic testing. AbstractAmbient ionisation mass spectrometry (AIMS) is a form of mass spectrometry whereby analyte ionisation occurs outside of a vacuum source under ambient conditions. This enables the direct analysis of samples in their native state, with little or no sample preparation and without chrom...
Source: Drug Testing and Analysis - February 8, 2024 Category: Drugs & Pharmacology Authors: Alisha Henderson,
Liam M. Heaney,
Stephanie Rankin ‐Turner Tags: REVIEW ARTICLE Source Type: research
Evaluation of a single Eporatio ® micro‐dose in urine and dried blood spots
A micro-dose (15 IU/kg) of the recombinant human erythropoietin Eporatio® given to male subjects resulted in the following findings from the urine and dried blood spot (DBS) analyses: Eporatio® was detected in all urine and DBS samples 10–36 h after micro-dose administration; after 72 h, 40% of urine samp les and 60% of DBS samples were suspicious for the presence of Eporatio®; and there was no significant difference between Mitra® VAMS and Capitainer® B50 DBS devices in the EPO signal intensities. AbstractRecombinant human erythropoietin (rhEPO) has been abused as a performance enhancer in sports for several...
Source: Drug Testing and Analysis - February 7, 2024 Category: Drugs & Pharmacology Authors: Carmel E. Heiland,
Mikael Lehtihet,
Annica B örjesson,
Lena Ekström Tags: SHORT COMMUNICATION Source Type: research
