Infant exposure to drugs of abuse investigated by hair analysis
A retrospective study was performed on hair analysis of children under 1 year of age. Based on the presence or absence of symptoms in the request for analysis, two groups of children were further identified. Cocaine was the most frequently detected substance, and it was detected less frequently in cases investigated for suspicious clinical symptom. The results confirmed the difficulties in interpreting the clinical picture and in defining the extent of exposure to drugs of abuse. AbstractInfant exposure to drugs of abuse represents a worldwide problem whose extent is difficult to estimate. Despite the potentially serious h...
Source: Drug Testing and Analysis - March 17, 2024 Category: Drugs & Pharmacology Authors: Cestonaro Clara,
Terranova Claudio,
Cinquetti Alessandro,
Russo Alessia,
Aprile Anna,
Favretto Donata Tags: RESEARCH ARTICLE Source Type: research
Performance ‐enhancing substances in sport: A scientometric review of 75 years of research
This study analyzes doping literature, identifying influential documents and research domains. While prevalent doping classes are well-studied, emerging trends like contaminated supplements receive less attention. Technological advancements drive sophisticated detection techniques. The study emphasizes the need for awareness campaigns among athletes. AbstractThe use of performance-enhancing substances not only undermines the core values of sports but also poses significant health risks to athletes. In a fast-evolving doping environment, where sport professionals are constantly seeking novel and illegal means to bypass dopi...
Source: Drug Testing and Analysis - March 16, 2024 Category: Drugs & Pharmacology Authors: Alessandro Carollo,
Ornella Corazza,
Maria Mantovani,
Nicol ò Silvestrini,
Olivier Rabin,
Gianluca Esposito Tags: RESEARCH ARTICLE Source Type: research
Synthesis, structural characterization, analytical profiling, and application to authentic samples of synthesized Phase I metabolites of the synthetic cannabinoid 5F ‐MDMB‐PICA
In this work, 18 reference standards were synthesized for 5F-MDMB-PICA and its possible Phase I metabolites. Their analytical differences were elucidated via NMR, FT-IR, UPLC-QTOF-MS, and LC –MS/MS. Ester hydrolyzedR17 was identified as a suitable urine biomarker by comparison with authentic samples. These findings contribute to the metabolite study and forensic detection of indole-type synthetic cannabinoids. Abstract5F-MDMB-PICA, an indole-type synthetic cannabinoid (SC), was classified illicit globally in 2020. Although the extensive metabolism of 5F-MDMB-PICA in the human body warrants the development of robust analy...
Source: Drug Testing and Analysis - March 16, 2024 Category: Drugs & Pharmacology Authors: Rui ‐Jia Chen,
Zi‐hua Zhang,
Shenglan Yang,
Shu‐chen Yu,
Jun‐chang Wang,
Ping‐yong Liao,
Ting‐ting Qiu,
Lu Xiao,
Shang Xue,
Hong Chen,
Wen‐bin Shao,
Jian‐wen Hu,
Yun Lan,
Xi‐long Chen,
Yue Xu,
Tian‐meng Zhou,
Xue‐jun Tags: RESEARCH ARTICLE Source Type: research
Comprehensive analysis of vitamin D3 impurities in oily drug products using supercritical fluid chromatography –mass spectrometry
This study presents the development of a method for detecting and quantifying seven impurities of vitamin D3 in oily drug products using supercritical fluid chromatography –mass spectrometry (SFC-MS). Targeted impurities include two esters of vitamin D3 and five non-esters including four that are isobaric to vitamin D3. Firstly, a screening study highlighted the Torus 1-AA column and acetonitrile modifier as adequate for the separation, followed by optimization of the SFC conditions. Secondly, make-up solvent composition and MS settings were optimized to reach high sensitivity. For both the separation and MS response, th...
Source: Drug Testing and Analysis - March 14, 2024 Category: Drugs & Pharmacology Authors: Hugues Jambo,
Amandine Dispas,
Leticia P érez‐Mayán,
Isaac Rodríguez,
Éric Ziemons,
Philippe Hubert Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
Interest of hair tests to discriminate a tail end of a doping regimen from a drug transfer between two individuals in case of challenging an anti ‐doping rule violation. IV. Case example with mesterolone
(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - March 14, 2024 Category: Drugs & Pharmacology Authors: Pascal Kintz,
Laurie Gheddar Tags: LETTER TO THE EDITOR Source Type: research
Analysing and quantifying chronic stress ‐associated endogenous steroids in hair samples
This study presents the development and validation of a method for the analysis of steroids in hair samples. The method was fully validated for seven steroids, and one steroid (estradiol) can be semi-quantitative analysed. Ten representative samples from an explorative study on adolescents are included in the present study. AbstractIn previous studies, various steroids have been associated with stress and have therefore been quantified to investigate stress-related questions. Since the main stress-related steroid cortisol follows a circadian rhythm, often hair is analysed to quantify this steroid. Further, hair analysis gi...
Source: Drug Testing and Analysis - March 13, 2024 Category: Drugs & Pharmacology Authors: Katharina Elisabeth Grafinger,
Wassilis Kassis,
C éline A. Favre,
Dilan Aksoy,
Stefan Gaugler Tags: RESEARCH ARTICLE Source Type: research
Cover Picture
(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - March 11, 2024 Category: Drugs & Pharmacology Tags: COVER PICTURE Source Type: research
Issue Information
No abstract is available for this article. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - March 11, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
Dried blood spots via remote testing as a possible future application in the doping control process
The use of DBS as biological matrix in combination with a novel technical remote testing app specifically developed for the doping control process shows that testing is becoming easier and variable through DBS. Supplemented by the remote testing solution, the system could significantly increase in the unpredictability of test dates and sample quantity. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - March 10, 2024 Category: Drugs & Pharmacology Authors: Stefan Trinks,
Kristina Braun,
Andrea Gotzmann,
Eva Bunthoff,
Dominic Mueser Tags: PERSPECTIVE Source Type: research
Metabolite markers for three synthetic tryptamines N ‐ethyl‐N‐propyltryptamine, 4‐hydroxy‐N‐ethyl‐N‐propyltryptamine, and 5‐methoxy‐N‐ethyl‐N‐propyltryptamine
We characterized the major metabolites of the synthetic tryptamines EPT, 4-OH-EPT, and 5-MeO-EPT after incubation with pooled human liver microsomes. The usefulness of the discovered metabolites in forensic casework was demonstrated by identification of unique metabolites for 4-OH-EPT in a human postmortem blood sample with suspected EPT or 4-OH-EPT intoxication. AbstractN-Ethyl-N-propyltryptamine (EPT), 4-hydroxy-N-ethyl-N-propyltryptamine (4-OH-EPT), and 5-methoxy-N-ethyl-N-propyltryptamine (5-MeO-EPT) are new psychoactive substances classified as tryptamines, sold online. Many tryptamines metabolize rapidly, and identif...
Source: Drug Testing and Analysis - March 9, 2024 Category: Drugs & Pharmacology Authors: Marianne Skov ‐Skov Bergh,
Inger Lise Bogen,
Katharina Elisabeth Grafinger,
Marilyn A. Huestis,
Åse Marit Leere Øiestad Tags: RESEARCH ARTICLE Source Type: research
Reliability of roadside oral fluid testing devices for ∆9‐tetrahydrocannabinol (∆9‐THC) detection
In this study, authors evaluated the sensitivity, specificity, efficiency, and predictive values of four different point-of-collection devices for THC detection in oral fluid at different confirmation cutoffs aiming their application in traffic enforcement. Oral fluid samples of 8945 drivers were screened. There were great differences in reliability parameters between devices; the implication of these results in traffic enforcement are presented and discussed in the paper. AbstractDriving under the influence of cannabis (DUIC) is increasing worldwide, and cannabis is the most prevalent drug after alcohol in impaired drivin...
Source: Drug Testing and Analysis - March 6, 2024 Category: Drugs & Pharmacology Authors: Juliana Nichterwitz Scherer,
Mailton Vasconcelos,
Carolina Silveira Dalanhol,
Bruna Govoni,
Bruno Pereira dos Santos,
Gabriela Ramos Borges,
Giovanna Cristiano de Gouveia,
Patr ícia Pacheco Viola,
Renato Luiz Romera Carlson,
Aline Franco Martins Tags: RESEARCH ARTICLE Source Type: research
Determination of higenamine in common natural spices by ultrahigh ‐performance liquid chromatography–tandem mass spectrometry
In this study, a comprehensive and systematic analysis of the HG content in five batches of samples from each of the 48 natural spices selected for this investigation was conducted using UPLC–MS/MS technology. Method validation was carried out in accordance with the ICH Analytical Procedu res and Methods Validation for Drugs and Biologics Guidance, and the experimental results demonstrated that the method provided appropriate sensitivity, precision, stability, linearity, and accuracy. HG was detected for the first time inHouttuynia cordata,Zingiber officinale,Cinnamomum cassia,Stevia rebaudiana,Piper nigrum,Siraitia gros...
Source: Drug Testing and Analysis - March 5, 2024 Category: Drugs & Pharmacology Authors: Jinming Du,
Xuefen Li,
Wenyi Tian,
Chengjun Guo Tags: SHORT COMMUNICATION Source Type: research
Detection of doping substances in paired dried blood spots and urine samples collected during doping controls in Danish fitness centers
We developed a feasible, sensitive, and robust method for simultaneous detection of 19 selected prohibited substances from S1 to S5 in dried blood spots (DBS) and compared the detectability of these prohibited substances in paired DBS and urine samples collected during doping controls in Danish fitness centers. AbstractThe use of dried blood spot (DBS) in anti-doping can be advantageous in terms of collection, transportation, and storage compared with the traditional anti-doping testing matrices urine and venous blood. There could, nonetheless, be disadvantages such as shorter detection windows for some substances compared...
Source: Drug Testing and Analysis - March 4, 2024 Category: Drugs & Pharmacology Authors: Maren Christin Stillesby Levern æs,
Sara A. Solheim,
Lillian Broderstad,
Essa Zandy,
Jakob Mørkeberg,
Yvette Dehnes Tags: RESEARCH ARTICLE Source Type: research
Obituary Don H. Catlin
(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - March 1, 2024 Category: Drugs & Pharmacology Authors: Mario Thevis Tags: SPECIAL ISSUE ‐ LETTER TO THE EDITOR Source Type: research
The origin of 2,5 ‐dimethoxy‐4‐methylamphetamine (DOM, STP)
In June of 1967, the drug 1-(2,5-dimethoxy-4-methylphenyl)propan-2-amine (DOM, STP) made an infamous and highly publicized appearance on the streets. During the course of digitizing its inventor's archive, the authors attempt to fill in missing details and provide a more accurate accounting of its release and short life as a street drug. The positive and lasting contributions of DOM to later neurochemical research and to drug crisis response are also discussed. AbstractThe story of the 1967 appearance of the powerful psychedelic 2,5-dimethoxy-4-methylamphetamine (DOM, STP) commonly omits details and often includes hyperbol...
Source: Drug Testing and Analysis - February 29, 2024 Category: Drugs & Pharmacology Authors: Keeper Trout,
Paul F. Daley Tags: PERSPECTIVE Source Type: research
