QuEChERS as alternative extraction procedure in doping analyses
QuEChERS, a dispersive solid phase extraction commonly applied in food analysis for residues, was investigated for its applicability for doping analysis. Using 10 M ammonium acetate with 3% formic acid, 90% of the analytes routinely targeted by HPLC-MS/MS could be extracted. Moreover, an improved extractability was observed for stanozolol-glucuronides and the HIF stabilizer FG-4592. AbstractQuEChERS is a dispersive solid phase extraction commonly applied in food analysis for residues, such as pesticides or mycotoxins for more than 20 years. Due to the quick and easy sample preparation procedure, a QuEChERS method based ...
Source: Drug Testing and Analysis - December 4, 2023 Category: Drugs & Pharmacology Authors: Daniel Derwand,
Sebastian Rzeppa,
Sven C. Voss,
Annette Zschiesche,
Annekathrin M. Keiler Tags: SPECIAL ISSUE ‐ SHORT COMMUNICATION Source Type: research
Storage stability of phosphatidylethanol homologues in whole blood and dried blood spots of nonalcoholics at different temperatures over 60 days
This study gained further information on the long-term stability of five PEth homologues (16:0/18:1, 16:0/18:2, 16:0/20:4, 18:0/18:1, 18:0/18:2) in whole blood (WB) and dried blood spots (DBS) stored at −80°C, 4°C, and room temperature (18°C) over a period of 60 days. All homologues, except PEth 16:0/20:4, were stable at −80°C in DBS and WB for 60 days. The initial PEth 16:0/18:1 concentrations remained stable in both DBS and WB in all but one volunteers' specimen at 4 and 18°C. AbstractPhosphatidylethanol (PEth) has recently become a popular direct alcohol marker for evaluating drinking behavior. This study a...
Source: Drug Testing and Analysis - December 4, 2023 Category: Drugs & Pharmacology Authors: Josefine Herzog,
Gisela Skopp,
Frank Musshoff,
Benno Hartung Tags: RESEARCH ARTICLE Source Type: research
Substandard and falsified ivermectin tablets obtained for self ‐medication during the COVID‐19 pandemic as a source of potential harm
Quality control analysis of substandard and falsified ivermectin samples indicate that none of the samples were not complaint to the quality criteria that are set for medicinal products. The majority of the analyzed samples demonstrated an underdosing, and half of the samples were contaminated with bacteria, including pathogenic bacteria. These findings plead for a continuous vigilance of regulatory agencies and inform and warn patients of the risks associated with the self-medication of prescription medicines, which are easily accessible online. AbstractIn 2019, a global viral pandemic, due to the SARS-CoV-2 virus, broke ...
Source: Drug Testing and Analysis - December 4, 2023 Category: Drugs & Pharmacology Authors: Celine Vanhee,
Bram Jacobs,
Ang élique Kamugisha,
Michael Canfyn,
Hans Van Der Meersch,
Bart Ceyssens,
Eric Deconinck,
Koenraad Van Hoorde,
Marie Willocx Tags: RESEARCH ARTICLE Source Type: research
Understanding sensitivity and cross ‐reactivity of xylazine lateral flow immunoassay test strips for drug checking applications
This study explored the drug checking applicability of the first publicly available xylazine test strips (XTS) using four sub-studies: reproducibility (i.e., consistency of positive results in a highly-concentrated xylazine solution) ; limit of detection on a calibration curve of xylazine concentrations; cross-reactivity against 77 commonly encountered drugs, cutting agents, and other structurally similar compounds; and applicability for analyzing community-acquired samples—where 100 drug residue samples were analyzed using XT S, direct analysis in real time mass spectrometry (DART-MS), and gas chromatography tandem mass...
Source: Drug Testing and Analysis - December 4, 2023 Category: Drugs & Pharmacology Authors: Edward Sisco,
Danielle F. Nestadt,
Madeline B. Bloom,
Kristin E. Schneider,
Rae A. Elkasabany,
Saba Rouhani,
Susan G. Sherman Tags: SHORT COMMUNICATION Source Type: research
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(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - December 1, 2023 Category: Drugs & Pharmacology Tags: COVER PICTURE Source Type: research
Issue Information
No abstract is available for this article. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - December 1, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
Cover Picture
(Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - December 1, 2023 Category: Drugs & Pharmacology Tags: COVER PICTURE Source Type: research
Issue Information
No abstract is available for this article. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - December 1, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
Detection in seized samples, analytical characterization, and in vitro metabolism of the newly emerged 5 ‐bromo‐indazole‐3‐carboxamide synthetic cannabinoid receptor agonists
This study reports the detection of the new synthetic cannabinoids ADB-5 ′Br-INACA and MDMB-5′Br-INACA in Scotland, Belgium, and the US, and ADB-5′Br-BUTINACA in Scotland and the US. These compounds, along with the predicted compound MDMB-5′Br-BUTINACA, were incubated with primary human hepatocytes to examine metabolic pathways and aid in toxicological identifica tion. AbstractSynthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances (NPS) and new structural scaffolds have emerged on the recreational drug market since the enactment of Chinese SCRA analog controls in 2021. Th...
Source: Drug Testing and Analysis - December 1, 2023 Category: Drugs & Pharmacology Authors: Caitlyn Norman,
Kristin Webling,
Oleksandra Kyslychenko,
Robert Reid,
Alex J. Krotulski,
Ryan Farrell,
Marie H. Deventer,
Huiling Liu,
Matthew J. Connolly,
Claude Guillou,
Inge M. J. Vinckier,
Barry K. Logan,
Niamh NicDa éid,
Craig McKenzie, Tags: RESEARCH ARTICLE Source Type: research
