Early appearance of dendritic alterations in neocortical pyramidal neurons of the Ts65Dn model of Down syndrome
This study shows dendritic branching defects that mainly involve the basal domain in P2 Ts65Dn mice, and the apical but not the other domains in P8 Ts65Dn mice. This suggests that dendritic defects may be related to dendritic compartment and age. The lack of a severe dendritic pathology in Ts65Dn pups is reminiscent of the delayed appearance of patent dendritic alterations in newborns with DS. This similarly highlights the usefulness of the Ts65Dn model for the study of the mechanisms underlying dendritic alterations in DS and the design of possible therapeutic interventions. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 1, 2021 Category: Neuroscience Source Type: research

Expression analyses of Rac3, a Rho family small GTPase, during mouse brain development
In this study, we carried out expression analyses of Rac3 with mouse brain tissues. In immunoblotting, Rac3 exhibited a tissue-dependent expression profile in the young adult mouse and was expressed in a developmental stage-dependent manner in brain. In primary cultured hippocampal neurons, while Rac3 was distributed mainly in the cytoplasm, it was visualized in axon and dendrites with partial localization at synapses, in consistent with the observation in biochemical fractionation analyses. In immunofluorescence analyses with brain slices, Rac3 was distributed strongly and moderately in the axon and cytoplasm, respectivel...
Source: Developmental Neuroscience - November 26, 2021 Category: Neuroscience Source Type: research

Visual development of healthy full-term infants under 24 months of age using the Preverbal Visual Assessment (PreViAs) questionnaire
As visual perception development proceeds rapidly after birth, early detection of developmental maturity is required. Healthy infants do not have many opportunities for visual perception evaluation, so a reliable evaluation method is necessary. This retrospective study included 276 healthy full-term infants less than 24 months of age using the Preverbal Visual Assessment (PreViAs) questionnaire, which measures scores of subdivided age groups for the global scores and four domains: visual attention (VA), visual communication (VC), visual-motor coordination (VMC) and visual processing (VP). Through this study, reference val...
Source: Developmental Neuroscience - November 17, 2021 Category: Neuroscience Source Type: research

6-shogaol exerts a neuroprotective factor in offspring after maternal immune activation in rats
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - October 25, 2021 Category: Neuroscience Source Type: research

Azithromycin Protects Oligodendrocyte Progenitor Cells against Lipopolysaccharide-activated Microglia-induced damage
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research

Cocaine Elevates Calcium-Dependent Activator Protein for Secretion 2 in the Mouse Orbitofrontal Cortex
Calcium-dependent activator protein for secretion 2 (CAPS2; also referred to as CADPS2) is a dense core vesicle-associated protein that promotes the activity-dependent release of neuropeptides including neurotrophins. Addictive drugs appear to prime neurotrophin release in multiple brain regions, but mechanistic factors are still being elucidated. Here, experimenters administered cocaine to adolescent mice at doses that potentiated later cocaine self-administration. Experimenter-administered cocaine elevated the CAPS2 protein content in the orbitofrontal cortex (OFC; but not striatum) multiple weeks after drug exposure. Me...
Source: Developmental Neuroscience - September 20, 2021 Category: Neuroscience Source Type: research

Cocaine elevates Calcium-dependent activator protein for secretion 2 (CAPS2) in the mouse orbitofrontal cortex
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 20, 2021 Category: Neuroscience Source Type: research

Author Index_Subject Index
Dev Neurosci 2021;43:262 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 10, 2021 Category: Neuroscience Source Type: research

Preliminaries
Dev Neurosci 2021;43:137 –140 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 10, 2021 Category: Neuroscience Source Type: research

Nonsyndromic Early-Onset Epileptic Encephalopathies: Two Novel < b > < i > KCTD7 < /i > < /b > Pathogenic Variants and a Literature Review
In conclusion,KCTD7 mutations demonstrate a diverse geographical distribution alongside a wide range of ethnicities. This highlights the importance of careful consideration in the WES data analysis. Mutations of this gene may be a common cause of NSEOEE. Also, this study imprints targeted therapeutic opportunities for potassium channelepsies such asKCTD7-related NSEOEE. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 1, 2021 Category: Neuroscience Source Type: research

Non Syndromic-Early Onset Epileptic Encephalopathies: Two novel KCTD7 pathogenic variants and a literature review
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 1, 2021 Category: Neuroscience Source Type: research

A novel variant of the KIF11 gene, c.2922G > T, is associated with Microcephaly by affecting RNA splicing
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - August 31, 2021 Category: Neuroscience Source Type: research

Pediatric Moderate-Severe Traumatic Brain Injury And Gray Matter Structural Covariance Networks: A Preliminary Longitudinal Investigation
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - August 12, 2021 Category: Neuroscience Source Type: research

Antisense Oligonucleotide Therapy for Neurodevelopmental Disorders
We describe the molecular mechanisms of ASO treatment for four neurodevelopmental and neuromuscular disorders. The ASO nusinersen is a general treatment for mutations ofSMN1 in spinal muscular atrophy that corrects the splicing defect in theSMN2 gene. Milasen is a patient-specific ASO that rescues splicing ofCNL7 in Batten ’s disease. STK-001 is an ASO that increases expression of the sodium channel geneSCN1A by exclusion of a poison exon. An ASO that reduces the abundance of theSCN8A mRNA is therapeutic in mouse models of developmental and epileptic encephalopathy. These examples demonstrate the variety of mechanisms an...
Source: Developmental Neuroscience - August 5, 2021 Category: Neuroscience Source Type: research

Mitochondrial Dysfunction: A Common Denominator in Neurodevelopmental Disorders?
Mitochondria, the organelles classically seen as the powerhouse of the cell, are increasingly associated with a wide variety of neurodevelopmental disorders. Although individually rare, a myriad of pediatric neurogenetic disorders have been identified in the last few years, thanks to advances in clinical genetic sequencing and data analysis. As this exponential growth continues, mitochondrial dysfunction is increasingly implicated in childhood neurodevelopmental disorders, with clinical presentations ranging from syndromic autism, intellectual disability, and epileptic encephalopathies to childhood onset neurodegeneration....
Source: Developmental Neuroscience - August 3, 2021 Category: Neuroscience Source Type: research