Orthographic depth may influence the degree of severity of maze learning performance in children at risk for reading disorder
In this study we examined whether low reading skill was associated with poor maze learning performance in native English-speaking and native German-speaking children, and the influence of genetic risk for RD on cognition and behavior. In addition, we investigated the link between genetic risk and performance on this task in an orthographically diverse sample of children attending an English-speaking international school in Germany. The results from our data suggest that children with low reading skill, or with a genetic risk for reading impairment, exhibit impaired performance on the maze learning task, regardless of ortho...
Source: Developmental Neuroscience - October 12, 2022 Category: Neuroscience Source Type: research
Carvedilol reduces the Neuronal apoptosis after ischemic stroke by modulating ATF3 expression in vitro
In conclusion, Carvedilol may be a key compound targeting ATF3 in OGD/R-PC12 cells. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - October 11, 2022 Category: Neuroscience Source Type: research
Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism
In this study, the involvement of the serotonin (5-HT) and kynurenine (KYN) pathways of tryptophan metabolism on the behavioral deficits induced by maternal stress during the late phase of gestation in mice was investigated. Adult offspring born to control or restraint-stressed dams were exposed to the elevated plus-maze and tail suspension tests. Metabolites of the KYN and 5-HT pathways were measured in the hippocampus and brainstem by ultra-performance liquid chromatography tandem mass spectrometry. Female, but not male, prenatally stressed (PNS) offspring displayed a depressive-like phenotype, mainly when in proestrus/d...
Source: Developmental Neuroscience - September 26, 2022 Category: Neuroscience Source Type: research
Maternal stress during pregnancy in mice induces sex-dependent behavioral alterations in offspring along with impaired serotonin and kynurenine pathways of tryptophan metabolism
In this study, the involvement of the serotonin (5-HT) and kynurenine (KYN) pathways of tryptophan metabolism on the behavioral deficits induced by maternal stress during the late phase of gestation in mice was investigated. Adult offspring born to control or restraint-stressed dams were exposed to the elevated plus-maze and tail suspension tests. Metabolites of the KYN and 5-HT pathways were measured in the hippocampus and brainstem by ultra ‐performance liquid chromatography‐tandem mass spectrometry. Female, but not male, prenatal stressed (PNS) offspring displayed a depressive-like phenotype, mainly when in proestru...
Source: Developmental Neuroscience - September 26, 2022 Category: Neuroscience Source Type: research
Subject Index Vol. 44, No. 4-5, 2022
Dev Neurosci 2022;44:427 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 12, 2022 Category: Neuroscience Source Type: research
Author Index Vol. 44, No. 4-5, 2022
Dev Neurosci 2022;44:426 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 12, 2022 Category: Neuroscience Source Type: research
Preliminaries
Dev Neurosci 2022;44:171 –174 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 12, 2022 Category: Neuroscience Source Type: research
Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development
In this study, we performed expression analyses of Plk4 by focusing on mouse brain development. Western blotting analyses revealed that Plk4 with a molecular mass of ∼100 kDa was broadly expressed in adult mouse tissues with specific subcellular distribution. As to the central nervous system, Plk4 was expressed throughout the developmental process with drastic increase after P15, suggesting an essential role of Plk4 in differentiated neurons. In immunohistoche mical analyses with mouse brain at embryonic day 14, Plk4 was detected dominantly at the cell-cell contact sites of neuronal progenitors in the ventricular zone. P...
Source: Developmental Neuroscience - September 6, 2022 Category: Neuroscience Source Type: research
Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development
In this study, we performed expression analyses of Plk4 by focusing on mouse brain development. Western blotting analyses revealed that Plk4 with a molecular mass of ∼100 kDa was broadly expressed in adult mouse tissues with specific subcellular distribution. As to the central nervous system, Plk4 was expressed throughout the developmental process with drastic increase after P15, suggesting an essential role of Plk4 in differentiated neurons. In immunohistoche mical analyses with mouse brain at embryonic day 14, Plk4 was detected dominantly at the cell-cell contact sites of neuronal progenitors in the ventricular zone. P...
Source: Developmental Neuroscience - September 6, 2022 Category: Neuroscience Source Type: research
Expression analyses of polo-like kinase 4 (Plk4), a gene product responsible for autosomal recessive microcephaly and Seckel syndrome, during mouse brain development
In this study, we performed expression analyses of Plk4 by focusing on mouse brain development. Western blotting analyses revealed that Plk4 with a molecular mass of ~100 kDa was broadly expressed in adult mouse tissues with specific subcellular distribution. As to the central nervous sytem, Plk4 was expressed throughout the developmental process with drastic increase after P15, suggesting an essential role of Plk4 in differentiated neurons. In immunohistochemical analyses with mouse brain at embryonic day 14, Plk4 was detected dominantly at the cell-cell contact sites of neuronal progenitors in the ventricular zone. Plk4 ...
Source: Developmental Neuroscience - September 6, 2022 Category: Neuroscience Source Type: research
