Prenatal Exposure to Tobacco and Alcohol Alters Development of the Neonatal Auditory System
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - July 19, 2021 Category: Neuroscience Source Type: research

Mapping Angiopoietin1 expression in the developing and adult brain
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - July 15, 2021 Category: Neuroscience Source Type: research

The Role of Hippo Signaling Pathway in the Development of the Nervous System
Hippo signaling pathway is a highly conserved and crucial signaling pathway that controls the size of tissues and organs by regulating the proliferation, differentiation, and apoptosis of cells. The nervous system is a complicated system that participates in information collection, integration, and procession. The balance of various aspects of the nervous system is vital for the normal regulation of physiological conditions of the body, like the population and distribution of nerve cells, nerve connections, and so on. Defects in these aspects may lead to cognitive, behavioral, and neurological dysfunction, resulting in var...
Source: Developmental Neuroscience - July 14, 2021 Category: Neuroscience Source Type: research

Febrile seizure-related miR-148a-3p exerts neuroprotection by promoting the proliferation of hippocampal neurons in children with temporal lobe epilepsy
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - July 9, 2021 Category: Neuroscience Source Type: research

Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3
Following preterm birth, serum levels of insulin-like growth factor 1 (IGF-1) decrease compared to corresponding in utero levels. A recent clinical trial indicated that supplementation with recombinant human (rh) IGF-1/rhIGF-binding protein 3 (rhIGF-1/rhIGFBP-3) prevents severe intraventricular hemorrhage (IVH) in extremely preterm infants. In a preterm rabbit pup model, we characterized endogenous serum and hepatic IGF-1, along with brain distribution of IGF-1 and IGF-1 receptor (IGF1R). We then evaluated the effects of rhIGF-1/rhIGFBP-3 on gene expression of regulators of cerebrovascular maturation and structure. Similar...
Source: Developmental Neuroscience - July 2, 2021 Category: Neuroscience Source Type: research

Identifying Dyslexia: Link between Maze Learning and Dyslexia Susceptibility Gene, < b > < i > DCDC2 < /i > < /b > , in Young Children
Dyslexia is a common learning disability that affects processing of written language despite adequate intelligence and educational background. If learning disabilities remain untreated, a child may experience long-term social and emotional problems, which influence future success in all aspects of their life. Dyslexia has a 60% heritability rate, and genetic studies have identified multiple dyslexia susceptibility genes (DSGs). DSGs, such asDCDC2, are consistently associated with the risk and severity of reading disability (RD). Altered neural connectivity within temporoparietal regions of the brain is associated with spec...
Source: Developmental Neuroscience - June 29, 2021 Category: Neuroscience Source Type: research

Dendritic Integration Dysfunction in Neurodevelopmental Disorders
Neurodevelopmental disorders (NDDs) that affect cognition, social interaction, and learning, including autism spectrum disorder (ASD) and intellectual disability (ID), have a strong genetic component. Our current understanding of risk genes highlights two main groups of dysfunction: those in genes that act as chromatin modifiers and those in genes that encode for proteins localized at or near synapses. Understanding how dysfunction in these genes contributes to phenotypes observed in ASD and ID remains a major question in neuroscience. In this review, we highlight emerging evidence suggesting that dysfunction in dendrites ...
Source: Developmental Neuroscience - June 17, 2021 Category: Neuroscience Source Type: research

Towards Targeted Therapy for Neurodevelopmental Disorders Symposium
Dev Neurosci (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - June 17, 2021 Category: Neuroscience Source Type: research

Effects of prenatal methamphetamine exposure on birth outcomes, brain structure, and neurodevelopmental outcomes
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - June 17, 2021 Category: Neuroscience Source Type: research

Molecular and Cellular Function of Transcription Factor 4 in Pitt-Hopkins Syndrome
In conclusion, we provide comments about exciting future avenues of research that may provide insights into potential new therapeutic targets for PTHS.Dev Neurosci (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - June 16, 2021 Category: Neuroscience Source Type: research

Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling
Minichromosome maintenance protein 5 (MCM5), a member of the microchromosomal maintenance protein family, plays an important role in the initiation and extension of DNA replication. However, its role in neural development in zebrafish remains unclear. Here, we used morpholino (MO) and CRISPR/Cas9 to knock downmcm5 and investigated the developmental features of facial motor neurons (FMNs) in the hindbrain of zebrafish. We found that knockdown ofmcm5 usingmcm5 MO resulted in a small head, small eyes, and a blurred midbrain-hindbrain boundary, while MO injection ofmcm5 led to decrease in FMNs and their migration disorder. How...
Source: Developmental Neuroscience - June 15, 2021 Category: Neuroscience Source Type: research

Galectin-3 modulates microglia inflammation in vitro but not neonatal brain injury in vivo under inflammatory conditions
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - June 15, 2021 Category: Neuroscience Source Type: research

Maternal Interleukin-6 Hampers Hippocampal Neurogenesis in Adult Rat Offspring in a Sex-Dependent Manner
The objective of this study was to assess whether this naturally occurring IL-6 has long-lasting effects on brain plasticity and function. Therefore, pregnant rats were given either an IL-6-neutralizing antibody (IL-6Ab) or vehicle during the third week of pregnancy. Newly born (doublecortin) and mature neurons (NeuN) were monitored in the hippocampus of adult male and female offspring. Prenatal IL-6Ab led to an enhanced number of newly born and mature neurons in the dentate gyrus of the hippocampus of male but not female adult offspring. This enhanced neurogenesis was associated with an increased propensity in memory acqu...
Source: Developmental Neuroscience - May 21, 2021 Category: Neuroscience Source Type: research

The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects
Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. Despite intensive research, its etiopathogenesis remains largely unclear. Although studies consistently reported dopaminergic anomalies, a coherent dopaminergic model of ASD was lacking until recently. In 2017, we provided a theoretical framework for a “dopamine hypothesis of ASD” which proposed that autistic behavior arises from a dysfunctional midbrain dopaminergic system. Namely, we hypothesized that malfunction of 2 critical circuits originating in the midbrain, that is, the m...
Source: Developmental Neuroscience - May 19, 2021 Category: Neuroscience Source Type: research

Enhancing Translational Developmental Cognitive Neuroscience with Advanced Neuroimaging Analyses
Dev Neurosci (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - May 12, 2021 Category: Neuroscience Source Type: research