Alterations in the proteome of developing neocortical synaptosomes in the absence of MET signaling revealed by comparative proteomics
Alterations in the expression of genes encoding proteins involved in synapse formation, maturation and function are a hallmark of many neurodevelopmental and psychiatric disorders. For example, there is reduced neocortical expression of the MET receptor tyrosine kinase (MET) transcript and protein in autism spectrum disorder and Rett syndrome. Preclinical in vivo and in vitro models manipulating MET signaling reveal that the receptor modulates excitatory synapse development and maturation in select forebrain circuits. The molecular adaptations underlying the altered synaptic development remain unknown. We performed a compa...
Source: Developmental Neuroscience - March 7, 2023 Category: Neuroscience Source Type: research
Impact of macrocephaly, as an isolated trait, on EEG signal as measured by spectral power and multiscale entropy during the first year of life
Macrocephaly has been associated with neurodevelopmental disorders; however, it has been mainly studied in the context of pathological or high-risk populations and little is known about its impact, as an isolated trait, on brain development in general population. Electroencephalographic (EEG) power spectral density (PSD) and signal complexity have shown to be sensitive to neurodevelopment and its alterations. We aimed to investigate the impact of macrocephaly as isolated trait on EEG signal as measured by power spectral density (PSD) and Multiscale Entropy (MSE) during the first year of life. We recorded high density EEG r...
Source: Developmental Neuroscience - February 23, 2023 Category: Neuroscience Source Type: research
Contents Vol. 44, 2022
Dev Neurosci 2022;44:I –VI (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - February 10, 2023 Category: Neuroscience Source Type: research
Acknowledgement to Reviewers
Dev Neurosci 2022;44:678 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - February 10, 2023 Category: Neuroscience Source Type: research
Maternal Immune Activation by Polyinosinic-Polycytidylic Acid Exposure Causes Cerebral Cortical Dysgenesis through Dysregulated Cell Cycle Kinetics of Neural Stem/Progenitor Cells
Maternal immune activation reportedly causes dysregulation of the cell cycle in stem cells and impairment of higher cortical function in rodents. Furthermore, in humans, maternal immune activation during the first to second trimester of pregnancy is strongly correlated with increased incidence of autism spectrum disorder in the offspring. Here, we show that in utero exposure to polyinosinic-polycytidylic acid (poly (I:C)) in mice during the early phase of neuronogenesis increases the probability of differentiation (quiescent fraction [Q fraction]) of neural stem/progenitor cells (NSPCs) without change in the length of cell...
Source: Developmental Neuroscience - January 24, 2023 Category: Neuroscience Source Type: research
Maternal immune activation by poly (I:C) exposure causes cerebral cortical dysgenesis through dysregulated cell cycle kinetics of neural stem/progenitor cells
Maternal immune activation reportedly causes dysregulation of the cell cycle in stem cells, and impairment of higher cortical function in rodents. Furthermore, in humans ’ maternal immune activation during the first to second trimester of pregnancy is strongly correlated with increased incidence of autism spectrum disorder in the offspring. Here, we show that in utero exposure to polyinosinic-polycytidylic acid (poly (I:C)) in mice during the early phase of neuron ogenesis increases the probability of differentiation (Q fraction) of neural stem/progenitor cells (NSPCs) without change in the length of cell cycle. This abn...
Source: Developmental Neuroscience - January 24, 2023 Category: Neuroscience Source Type: research
Cilia at the Crossroads of Tumor Treating Fields and Chemotherapy
Glioblastoma (GBM), the most common and lethal primary brain tumor in adults, requires multi-treatment intervention which unfortunately barely shifts the needle in overall survival. The treatment options after diagnosis and surgical resection (if possible) include irradiation, temozolomide (TMZ) chemotherapy, and now tumor treating fields (TTFields). TTFields are electric fields delivered locoregionally to the head/tumor via a wearable medical device (Optune®). Overall, the concomitant treatment of TTFields and TMZ target tumor cells but spare normal cell types in the brain. Here, we examine whether primary cilia, microtu...
Source: Developmental Neuroscience - January 17, 2023 Category: Neuroscience Source Type: research
Cilia at the Crossroads of Tumor Treating Fields and Chemotherapy
Glioblastoma (GBM), the most common and lethal primary brain tumor in adults, requires multi-treatment intervention which unfortunately barely shifts the needle in overall survival. The treatment options after diagnosis and surgical resection (if possible) include irradiation, temozolomide (TMZ) chemotherapy, and now Tumor Treating Fields (TTFields). TTFields are electric fields delivered locoregionally to the head/tumor via a wearable medical device (Optune ®). Overall, the concomitant treatment of TTFields and TMZ target tumor cells but spare normal cell types in the brain. Here, we examine whether primary cilia, microt...
Source: Developmental Neuroscience - January 17, 2023 Category: Neuroscience Source Type: research
Caspase-3 Inhibition toward Perinatal Protection of the Developing Brain from Environmental Stress
Throughout our lives, we are exposed to a variety of hazards, such as environmental pollutants and chemical substances that affect our health, and viruses and bacteria that cause infectious diseases. These external factors that are undesirable to an organism are called environmental stress. During the perinatal period, when neural networks are drastically reorganized and refined, the tolerance of the developing brain to various environmental stresses is lower than in adulthood. Thus, exposure to environmental stress during this vulnerable period is strongly associated with cognitive and behavioral deficits in later life. R...
Source: Developmental Neuroscience - January 13, 2023 Category: Neuroscience Source Type: research
Caspase-3 inhibition toward perinatal protection of the developing brain from environmental stress
Throughout our lives, we are exposed to a variety of hazards, such as environmental pollutants and chemical substances that affect our health, and viruses and bacteria that cause infectious diseases. These external factors that are undesirable to an organism are called environmental stress. During the perinatal period, when neural networks are drastically reorganized and refined, the tolerance of the developing brain to various environmental stresses is lower than in adulthood. Thus, exposure to environmental stress during this vulnerable period is strongly associated with cognitive and behavioral deficits in later life. R...
Source: Developmental Neuroscience - January 13, 2023 Category: Neuroscience Source Type: research
