Circ-Ctnnb1 regulates neuronal injury in spinal cord injury through Wnt/ β-catenin signaling pathway
Conclusion: Circ-Ctnnb1 promotes SCI through regulating Wnt/β-catenin signaling via modulating the miR-205-5p/Ctnnb1/Wnt2b axis. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 20, 2021 Category: Neuroscience Source Type: research
Deleterious Effect of Crossfostering in Rat Pups on Hypoxic-Ischaemic Injury Tolerance and Hypothermic Neuroprotection
In conclusion, crossfostering alters ou tcomes in our established model through reduced insult tolerance and variable neuroprotection. Crossfostering as a common breeding practice is a largely unexplored variable in animal research that may result in invalid research conclusions if inadequately adjusted for by larger group sizes. As a res ult, crossfostering is likely to be inconsistent with the principles of replacement, reduction, and refinement. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 15, 2021 Category: Neuroscience Source Type: research
The deleterious effect of crossfostering in rat pups on hypoxic-ischemic injury tolerance and hypothermic neuroprotection
In conclusion, crossfostering alters outco mes in our established model through reduced insult tolerance and variable neuroprotection. Crossfostering as a common breeding practice is a largely unexplored variable in animal research that may result in invalid research conclusions if inadequately adjusted for by larger group sizes. As a result , crossfostering is likely to be inconsistent with the principles of replacement, reduction, and refinement. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 15, 2021 Category: Neuroscience Source Type: research
Contents Vol. 43, 2021
Dev Neurosci 2021;43:I –VI (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 2, 2021 Category: Neuroscience Source Type: research
Acknowledgement to Reviewers
Dev Neurosci 2021;43:383 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 2, 2021 Category: Neuroscience Source Type: research
Early appearance of dendritic alterations in neocortical pyramidal neurons of the Ts65Dn model of Down syndrome
This study shows dendritic branching defects that mainly involve the basal domain in P2 Ts65Dn mice, and the apical but not the other domains in P8 Ts65Dn mice. This suggests that dendritic defects may be related to dendritic compartment and age. The lack of a severe dendritic pathology in Ts65Dn pups is reminiscent of the delayed appearance of patent dendritic alterations in newborns with DS. This similarly highlights the usefulness of the Ts65Dn model for the study of the mechanisms underlying dendritic alterations in DS and the design of possible therapeutic interventions. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - December 1, 2021 Category: Neuroscience Source Type: research
Expression analyses of Rac3, a Rho family small GTPase, during mouse brain development
In this study, we carried out expression analyses of Rac3 with mouse brain tissues. In immunoblotting, Rac3 exhibited a tissue-dependent expression profile in the young adult mouse and was expressed in a developmental stage-dependent manner in brain. In primary cultured hippocampal neurons, while Rac3 was distributed mainly in the cytoplasm, it was visualized in axon and dendrites with partial localization at synapses, in consistent with the observation in biochemical fractionation analyses. In immunofluorescence analyses with brain slices, Rac3 was distributed strongly and moderately in the axon and cytoplasm, respectivel...
Source: Developmental Neuroscience - November 26, 2021 Category: Neuroscience Source Type: research
Visual development of healthy full-term infants under 24 months of age using the Preverbal Visual Assessment (PreViAs) questionnaire
As visual perception development proceeds rapidly after birth, early detection of developmental maturity is required. Healthy infants do not have many opportunities for visual perception evaluation, so a reliable evaluation method is necessary.
This retrospective study included 276 healthy full-term infants less than 24 months of age using the Preverbal Visual Assessment (PreViAs) questionnaire, which measures scores of subdivided age groups for the global scores and four domains: visual attention (VA), visual communication (VC), visual-motor coordination (VMC) and visual processing (VP). Through this study, reference val...
Source: Developmental Neuroscience - November 17, 2021 Category: Neuroscience Source Type: research
6-shogaol exerts a neuroprotective factor in offspring after maternal immune activation in rats
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - October 25, 2021 Category: Neuroscience Source Type: research
Azithromycin Protects Oligodendrocyte Progenitor Cells against Lipopolysaccharide-activated Microglia-induced damage
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 27, 2021 Category: Neuroscience Source Type: research
Cocaine Elevates Calcium-Dependent Activator Protein for Secretion 2 in the Mouse Orbitofrontal Cortex
Calcium-dependent activator protein for secretion 2 (CAPS2; also referred to as CADPS2) is a dense core vesicle-associated protein that promotes the activity-dependent release of neuropeptides including neurotrophins. Addictive drugs appear to prime neurotrophin release in multiple brain regions, but mechanistic factors are still being elucidated. Here, experimenters administered cocaine to adolescent mice at doses that potentiated later cocaine self-administration. Experimenter-administered cocaine elevated the CAPS2 protein content in the orbitofrontal cortex (OFC; but not striatum) multiple weeks after drug exposure. Me...
Source: Developmental Neuroscience - September 20, 2021 Category: Neuroscience Source Type: research
Cocaine elevates Calcium-dependent activator protein for secretion 2 (CAPS2) in the mouse orbitofrontal cortex
(Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 20, 2021 Category: Neuroscience Source Type: research
Author Index_Subject Index
Dev Neurosci 2021;43:262 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 10, 2021 Category: Neuroscience Source Type: research
Preliminaries
Dev Neurosci 2021;43:137 –140 (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 10, 2021 Category: Neuroscience Source Type: research
Nonsyndromic Early-Onset Epileptic Encephalopathies: Two Novel < b > < i > KCTD7 < /i > < /b > Pathogenic Variants and a Literature Review
In conclusion,KCTD7 mutations demonstrate a diverse geographical distribution alongside a wide range of ethnicities. This highlights the importance of careful consideration in the WES data analysis. Mutations of this gene may be a common cause of NSEOEE. Also, this study imprints targeted therapeutic opportunities for potassium channelepsies such asKCTD7-related NSEOEE. (Source: Developmental Neuroscience)
Source: Developmental Neuroscience - September 1, 2021 Category: Neuroscience Source Type: research
