CD4+ Foxp3+ Regulatory T-cells in Modulating Inflammatory Microenvironment in Chronic Rhinosinusitis with Nasal Polyps: Progress and Future Prospect
Cytokine. 2024 Mar 6;178:156557. doi: 10.1016/j.cyto.2024.156557. Online ahead of print.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis (CRS) characterized by the presence of nasal polyps (NP) in the paranasal mucosa. Despite the complex etiology, NP is believed to result from chronic inflammation. The long-term aftermath of the type 2 response is responsible for symptoms seen in NP patients, i.e. rhinorrhea, hyposmia, and nasal obstruction. Immune cellular tolerogenic mechanisms, particularly CD4 + Foxp3 + regulatory T cells (Tregs), are crucial to curtail inflammatory resp...
Source: Cytokine - March 7, 2024 Category: Molecular Biology Authors: Nur Najwa Farahin M Yusoff Suhana Ahmad Wan Faiziah Wan Abdul Rahman Rohimah Mohamud Jennifer C Boer Magdalena Plebanski Baharudin Abdullah Xin Chen Tengku Ahmad Damitri Al-Astani Tengku Din Source Type: research
CD4+ Foxp3+ Regulatory T-cells in Modulating Inflammatory Microenvironment in Chronic Rhinosinusitis with Nasal Polyps: Progress and Future Prospect
Cytokine. 2024 Mar 6;178:156557. doi: 10.1016/j.cyto.2024.156557. Online ahead of print.ABSTRACTChronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis (CRS) characterized by the presence of nasal polyps (NP) in the paranasal mucosa. Despite the complex etiology, NP is believed to result from chronic inflammation. The long-term aftermath of the type 2 response is responsible for symptoms seen in NP patients, i.e. rhinorrhea, hyposmia, and nasal obstruction. Immune cellular tolerogenic mechanisms, particularly CD4 + Foxp3 + regulatory T cells (Tregs), are crucial to curtail inflammatory resp...
Source: Cytokine - March 7, 2024 Category: Molecular Biology Authors: Nur Najwa Farahin M Yusoff Suhana Ahmad Wan Faiziah Wan Abdul Rahman Rohimah Mohamud Jennifer C Boer Magdalena Plebanski Baharudin Abdullah Xin Chen Tengku Ahmad Damitri Al-Astani Tengku Din Source Type: research
Cytokine storm in human monkeypox: A possible involvement of purinergic signaling
Cytokine. 2024 Mar 5;177:156560. doi: 10.1016/j.cyto.2024.156560. Online ahead of print.ABSTRACTSome evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence that consolidates the role of the cytokine storm in monkeypox infection and proposes a new hypothesis regarding the roles of ...
Source: Cytokine - March 6, 2024 Category: Molecular Biology Authors: Gilnei Bruno da Silva Ge órgia de Carvalho Braga J úlia Leão Batista Simões Aniela Pinto Kempka Margarete Dulce Bagatini Source Type: research
Cytokine storm in human monkeypox: A possible involvement of purinergic signaling
Cytokine. 2024 Mar 5;177:156560. doi: 10.1016/j.cyto.2024.156560. Online ahead of print.ABSTRACTSome evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence that consolidates the role of the cytokine storm in monkeypox infection and proposes a new hypothesis regarding the roles of ...
Source: Cytokine - March 6, 2024 Category: Molecular Biology Authors: Gilnei Bruno da Silva Ge órgia de Carvalho Braga J úlia Leão Batista Simões Aniela Pinto Kempka Margarete Dulce Bagatini Source Type: research
Plasmatic profiles of cytokines/chemokines, glial fibrillary acidic protein (GFAP) and MRI brain damage in neonates with hypoxic ischemic encephalopathy (HIE)
CONCLUSION: In a small number of infants with worse brain MRI, we found higher levels of GFAP and of IL-10 at T4 and a trend toward low IL-18 levels than in infants with normal MRI, considered early biomarker of brain damage and a predictor of adverse outcome, respectively. The greatest, although not significant, difference between the levels of molecules was found in cases and controls at time points T2 and T3, during TH.PMID:38442443 | DOI:10.1016/j.cyto.2024.156565 (Source: Cytokine)
Source: Cytokine - March 5, 2024 Category: Molecular Biology Authors: Cinzia Auriti Vito Mond ì Fiammetta Piersigilli Laura Timelli Tamara Del Pinto Giusi Prencipe Giulia Lucignani Daniela Longo Iliana Bersani Source Type: research
Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression
CONCLUSION: As a result, the relationship between different serum levels of cytokine IL-6 with different titers of IgM and IgG antibodies was observed in both male and female populations. In general, it can be concluded that the correlation between different concentrations of IL-6 with different IgM titers was similar in both men and women, but in the case of different IgG titers, this correlation was higher in women than men.PMID:38432065 | DOI:10.1016/j.cyto.2024.156564 (Source: Cytokine)
Source: Cytokine - March 3, 2024 Category: Molecular Biology Authors: Samaneh Mollazadeh Mahmoud Mahmoudi Mojgan Mohammadi Ramiar Kamal Kheder Hussein Nasiri Mahallati Salime Sarbaz Haghighi Elnaz Masoumi Zahra Javanmardi Seyed-Alireza Esmaeili Source Type: research
Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression
CONCLUSION: As a result, the relationship between different serum levels of cytokine IL-6 with different titers of IgM and IgG antibodies was observed in both male and female populations. In general, it can be concluded that the correlation between different concentrations of IL-6 with different IgM titers was similar in both men and women, but in the case of different IgG titers, this correlation was higher in women than men.PMID:38432065 | DOI:10.1016/j.cyto.2024.156564 (Source: Cytokine)
Source: Cytokine - March 3, 2024 Category: Molecular Biology Authors: Samaneh Mollazadeh Mahmoud Mahmoudi Mojgan Mohammadi Ramiar Kamal Kheder Hussein Nasiri Mahallati Salime Sarbaz Haghighi Elnaz Masoumi Zahra Javanmardi Seyed-Alireza Esmaeili Source Type: research
Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression
CONCLUSION: As a result, the relationship between different serum levels of cytokine IL-6 with different titers of IgM and IgG antibodies was observed in both male and female populations. In general, it can be concluded that the correlation between different concentrations of IL-6 with different IgM titers was similar in both men and women, but in the case of different IgG titers, this correlation was higher in women than men.PMID:38432065 | DOI:10.1016/j.cyto.2024.156564 (Source: Cytokine)
Source: Cytokine - March 3, 2024 Category: Molecular Biology Authors: Samaneh Mollazadeh Mahmoud Mahmoudi Mojgan Mohammadi Ramiar Kamal Kheder Hussein Nasiri Mahallati Salime Sarbaz Haghighi Elnaz Masoumi Zahra Javanmardi Seyed-Alireza Esmaeili Source Type: research
Th2-predominant immune response underlies the pathogenesis of Dengue
CONCLUSION: The study reveals a Th2-predominant immune response in all Dengue patients, regardless of disease severity, with overexpression of IL-8 and MIP-1α being observed in patients with warning signs.PMID:38430693 | DOI:10.1016/j.cyto.2024.156562 (Source: Cytokine)
Source: Cytokine - March 2, 2024 Category: Molecular Biology Authors: Dipesh Kale Ashish Kumar Vyas Girish Chandra Bhatt Ashvini Kumar Yadav Anirudh K Singh Shashwati Nema Debasis Biswas Source Type: research
Cancer energy reprogramming and the immune responses
This study highlighted some prospects and future experiments in harnessing the host immune response towards the altered energy metabolism due to cancer.PMID:38430694 | DOI:10.1016/j.cyto.2024.156561 (Source: Cytokine)
Source: Cytokine - March 2, 2024 Category: Molecular Biology Authors: Yuan Xingxing Serge Yannick Ouedraogo Muhammed Tarawally Yurong Tan Ousman Bajinka Source Type: research
Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice
CONCLUSIONS: Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.PMID:38417214 | DOI:10.1016/j.cyto.2024.156556 (Source: Cytokine)
Source: Cytokine - February 28, 2024 Category: Molecular Biology Authors: Chenggang Huang Jiajia Teng Wei Liu Junzhe Wang An Liu Source Type: research
Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice
CONCLUSIONS: Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.PMID:38417214 | DOI:10.1016/j.cyto.2024.156556 (Source: Cytokine)
Source: Cytokine - February 28, 2024 Category: Molecular Biology Authors: Chenggang Huang Jiajia Teng Wei Liu Junzhe Wang An Liu Source Type: research
Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice
CONCLUSIONS: Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.PMID:38417214 | DOI:10.1016/j.cyto.2024.156556 (Source: Cytokine)
Source: Cytokine - February 28, 2024 Category: Molecular Biology Authors: Chenggang Huang Jiajia Teng Wei Liu Junzhe Wang An Liu Source Type: research
Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice
CONCLUSIONS: Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.PMID:38417214 | DOI:10.1016/j.cyto.2024.156556 (Source: Cytokine)
Source: Cytokine - February 28, 2024 Category: Molecular Biology Authors: Chenggang Huang Jiajia Teng Wei Liu Junzhe Wang An Liu Source Type: research
Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia
In this study we investigated the effects of hookworm infection on iron metabolism and how the hosts response to anemia is affected using hamsters infected with Ancylostoma ceylanicum as a model. Our data revealed interesting relationships between infection-induced anemia, erythropoiesis, iron metabolism, and immune modulation, such that the elevated production of erythropoietin (EPO) in renal tissue indicated intensified erythropoiesis in response to anemia. Additionally, the increased expression of the erythroferrone (ERFE) gene in the spleen suggested its involvement in iron regulation and erythropoiesis. Gene expressio...
Source: Cytokine - February 27, 2024 Category: Molecular Biology Authors: Luis Fernando Viana Furtado William Pereira Alves Vivian Jordania da Silva Élida Mara Leite Rabelo Source Type: research
