Cytokine responses to major human Cytomegalovirus antigens in mouse model
Cytokine. 2024 Feb 14;176:156546. doi: 10.1016/j.cyto.2024.156546. Online ahead of print.ABSTRACTHuman cytomegalovirus (CMV) continues to be a source of severe complications in immunologically immature and immunocompromised hosts. Effective CMV vaccines that help diminish CMV disease in transplant patients and avoid congenital infection are essential. Though the exact roles of defense mechanisms are unidentified, virus-specific antibodies and cytokine responses are known to be involved in controlling CMV infections. Identifying the CMV antigens that trigger these protective immune responses will help us choose the most sui...
Source: Cytokine - February 15, 2024 Category: Molecular Biology Authors: Sahar Essa Hussain A Safar Raj Raghupathy Source Type: research
The ever-expanding role of cytokine receptor DR3 in T cells
Cytokine. 2024 Feb 14;176:156540. doi: 10.1016/j.cyto.2024.156540. Online ahead of print.ABSTRACTDeath Receptor 3 (DR3) is a cytokine receptor of the Tumor Necrosis Factor receptor superfamily that plays a multifaceted role in both innate and adaptive immunity. Based on the death domain motif in its cytosolic tail, DR3 had been proposed and functionally affirmed as a trigger of apoptosis. Further studies, however, also revealed roles of DR3 in other cellular pathways, including inflammation, survival, and proliferation. DR3 is expressed in various cell types, including T cells, B cells, innate lymphocytes, myeloid cells, f...
Source: Cytokine - February 15, 2024 Category: Molecular Biology Authors: Nurcin Liman Dominic Lanasa Fran çoise Meylan Jung-Hyun Park Source Type: research
Cytokine responses to major human Cytomegalovirus antigens in mouse model
Cytokine. 2024 Feb 14;176:156546. doi: 10.1016/j.cyto.2024.156546. Online ahead of print.ABSTRACTHuman cytomegalovirus (CMV) continues to be a source of severe complications in immunologically immature and immunocompromised hosts. Effective CMV vaccines that help diminish CMV disease in transplant patients and avoid congenital infection are essential. Though the exact roles of defense mechanisms are unidentified, virus-specific antibodies and cytokine responses are known to be involved in controlling CMV infections. Identifying the CMV antigens that trigger these protective immune responses will help us choose the most sui...
Source: Cytokine - February 15, 2024 Category: Molecular Biology Authors: Sahar Essa Hussain A Safar Raj Raghupathy Source Type: research
The ever-expanding role of cytokine receptor DR3 in T cells
Cytokine. 2024 Feb 14;176:156540. doi: 10.1016/j.cyto.2024.156540. Online ahead of print.ABSTRACTDeath Receptor 3 (DR3) is a cytokine receptor of the Tumor Necrosis Factor receptor superfamily that plays a multifaceted role in both innate and adaptive immunity. Based on the death domain motif in its cytosolic tail, DR3 had been proposed and functionally affirmed as a trigger of apoptosis. Further studies, however, also revealed roles of DR3 in other cellular pathways, including inflammation, survival, and proliferation. DR3 is expressed in various cell types, including T cells, B cells, innate lymphocytes, myeloid cells, f...
Source: Cytokine - February 15, 2024 Category: Molecular Biology Authors: Nurcin Liman Dominic Lanasa Fran çoise Meylan Jung-Hyun Park Source Type: research
Th17/IL-17A axis is critical for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc): SSc patients with high levels of serum IL-17A exhibit reduced lung functions and increased prevalence of PAH
CONCLUSION: We found that SSc patients with high levels of serum IL-17A or both IL-17A and IL-6 show reduced lung functions and high prevalence of PAH. Consequently, it is highly probable that Th17/IL-17A axis is critical for the prevalence of PAH in SSc patients.PMID:38354516 | DOI:10.1016/j.cyto.2024.156534 (Source: Cytokine)
Source: Cytokine - February 14, 2024 Category: Molecular Biology Authors: Noriyasu Seki Hideto Tsujimoto Shuhei Tanemura Sho Ishigaki Hiroshi Takei Kunio Sugahara Keiko Yoshimoto Mitsuhiro Akiyama Yuko Kaneko Kenji Chiba Tsutomu Takeuchi Source Type: research
A novel therapeutic approach to modulate the inflammatory cascade: A timely exogenous local inflammatory response attenuates the sepsis-induced cytokine storm
CONCLUSIONS: Compared with the initial stage of inflammation, low-scale inflammation caused by a certain intensity of eLIR (3 sessions) on the body surface can more effectively pry the inflammation aggravation time-point, thereby shifting the pro-inflammatory to anti-inflammatory milieu, impeding the disproportionate cytokines release in inflammatory diseases, slowing down the inflammatory cascade, and improving the survival rate of sepsis.PMID:38340550 | DOI:10.1016/j.cyto.2024.156533 (Source: Cytokine)
Source: Cytokine - February 10, 2024 Category: Molecular Biology Authors: Meng Gong Shiyi Qi Zhiting Wu Ying Huang Lihua Wu Xiangbin Wang Lingling He Lili Lin Dong Lin Source Type: research
Macrophage inhibitory factor alters the functionality of macrophages and their involvement in disease pathogenesis of active generalized vitiligo patients
CONCLUSION: Elevated macrophages in both tissue and blood enhanced the secretion of MIF and other inflammatory mediators that further enforce the production of nitric oxide, activation and phagocytic activity of macrophages against melanocytes and melanocytes antigens. As a result, destruction of melanocytes and melanin production occurred and caused the depigmentation and/or white macules on the skin.PMID:38340551 | DOI:10.1016/j.cyto.2024.156516 (Source: Cytokine)
Source: Cytokine - February 10, 2024 Category: Molecular Biology Authors: Nikita Sain Vishakha Hooda Ashu Singh Somesh Gupta Sudheer Arava Alpana Sharma Source Type: research
Antiviral treatment significantly reduces the levels of CXCL9, CXCL10 and CXCL11 in chronic hepatitis C
In this study, we aimed to elucidate the changes in the immune response during antiviral treatment of patients with chronic hepatitis C, with an emphasis on the chemokine dynamics and their association with liver fibrosis. Serum concentrations of 12 chemokines. (CCL2, CCL3, CCL4, CCL11, CCL17, CCL20, CXCL1, CXCL5, CXCL8, CXCL9, CXCL10 and CXCL11) were measured in 32 patients with chronic hepatitis C before direct-acting antiviral treatment and after sustained virological response using bead-based flow cytometry. Chemokine levels were also measured in 14 sex- and age-matched healthy individuals. Concentrations of CXCL9, CXC...
Source: Cytokine - February 9, 2024 Category: Molecular Biology Authors: Leona Radmani ć Petra Šimičić Kristian Boduli ć Adriana Vince Snjezana Zidovec-Lepej Source Type: research
sPD-L1 and sPD-L2 in plasma of patients with lung cancer and their clinical significance
CONCLUSIONS: The combination of sPD-L1 and sPD-L2 could be used as adjunctive diagnostic, High level of plasma sPD-L1 rather than sPD-L2 is associated with poor prognosis in lung cancer patients.PMID:38330638 | DOI:10.1016/j.cyto.2024.156532 (Source: Cytokine)
Source: Cytokine - February 8, 2024 Category: Molecular Biology Authors: Shiyang Han Yan Zhang Jingzhi Yuan Yi Wu Yun Zhou Yan Zhou Xiaowei Li Shuru Zhou Source Type: research
Delayed CCL23 response is associated with poor outcomes after cardiac arrest
Cytokine. 2024 Feb 6;176:156536. doi: 10.1016/j.cyto.2024.156536. Online ahead of print.ABSTRACTChemokines, a family of chemotactic cytokines, mediate leukocyte migration to and entrance into inflamed tissue, contributing to the intensity of local inflammation. We performed an analysis of chemokine and immune cell responses to cardiac arrest (CA). Forty-two patients resuscitated from cardiac arrest were analyzed, and twenty-two patients who underwent coronary artery bypass grafting (CABG) surgery were enrolled. Quantitative antibody array, chemokines, and endotoxin quantification were performed using the patients blood. An...
Source: Cytokine - February 7, 2024 Category: Molecular Biology Authors: Joanne T deKay Elena Chepurko Vadim Chepurko Lacey Knudsen Christine Lord Meghan Searight Sergey Tsibulnikov Michael P Robich Douglas B Sawyer David J Gagnon Teresa May Richard Riker David B Seder Sergey Ryzhov Source Type: research
Inhibition of HMGB1 improves experimental mice colitis by mediating NETs and macrophage polarization
CONCLUSION: Inhibition of HMGB1 ameliorates IBD by mediating NETs and macrophage polarization.PMID:38325140 | DOI:10.1016/j.cyto.2024.156537 (Source: Cytokine)
Source: Cytokine - February 7, 2024 Category: Molecular Biology Authors: Xiaohong Chen SaChuLa Bao Meng Liu Zheng Han Jie Tan Qingxi Zhu Xiaodong Huang Xia Tian Source Type: research
A gain of function mutation in AKT1 increases hexokinase 2 and diminishes oxidative stress in meningioma
Cytokine. 2024 Feb 6;176:156535. doi: 10.1016/j.cyto.2024.156535. Online ahead of print.ABSTRACTIncreasing evidence suggests the oncogenic role of missense mutation (AKT1-E17K) of AKT1 gene in meningiomas. Upon investigating the connection between the pro-tumorigenic role of AKT1-E17K and cellular metabolic adaptations, elevated levels of glycolytic enzyme hexokinase 2 (HK2) was observed in meningioma patients with AKT1-E17K compared to patients harboring wild-type AKT1. In vitro experiments also suggested higher HK2 levels and its activity in AKT1-E17K cells. Treatment with the conventional drug of choice AZD5363 (a pan A...
Source: Cytokine - February 7, 2024 Category: Molecular Biology Authors: Swati Singh Kirti Lathoria Sonia B Umdor Jyotsna Singh Vaishali Suri Ellora Sen Source Type: research
Long non-coding RNA Linc00657 up-regulates Skp2 to promote the progression of cervical cancer through lipid reprogramming and regulation of immune microenvironment
Cytokine. 2024 Feb 2;176:156510. doi: 10.1016/j.cyto.2024.156510. Online ahead of print.ABSTRACTMore and more evidence shows that long non-coding RNA (lncRNA) plays an important role in the biological behavior of many kinds of malignant tumors, but the specific function of lncRNA Linc00657 in cervical cancer is still unknown. The purpose of this study is to explore the effect of Linc00657 on the malignant progression of cervical cancer and its potential mechanism. In two kinds of cervical cancer cell lines and normal cervical epithelial cells, qRT-PCR showed increased expression of Linc00657 in cervical cancer cells. Throu...
Source: Cytokine - February 3, 2024 Category: Molecular Biology Authors: Yuting Li Gulikezi Maimaitirexiati Jing Wang Jin Zhang Ping Tian Changhui Zhou Jingqin Ren Lingjie Wang Jiaqi Zhao Hengyu Wang Zhen Chen Xue Li Qi Yan Nazila Saitiniyazi Chengqing Liu Jiabo Wang Nan Yang Xiaoya Xu Lu Ding Cailing Ma Rong Li Source Type: research
Early changes in serum interleukin-6 levels in extremely premature newborns for detecting fetal inflammation
CONCLUSIONS: Serum IL-6 levels in EPNs significantly increase early after birth, then decrease to at-delivery levels by 24-36 h of life. Therefore, postnatal age-dependent cut-off values of serum IL-6 might be considered for detecting fetal inflammation with confirmed funisitis.PMID:38308952 | DOI:10.1016/j.cyto.2024.156528 (Source: Cytokine)
Source: Cytokine - February 3, 2024 Category: Molecular Biology Authors: Sota Iwatani Takao Kobayashi Toshihiko Ikuta Makiko Yoshida Seiji Yoshimoto Source Type: research
Natural variability of TRAIL, IP-10, and CRP in healthy adults - The "HERACLES" study
Cytokine. 2024 Feb 1;176:156530. doi: 10.1016/j.cyto.2024.156530. Online ahead of print.ABSTRACTA novel host-protein score (called MMBV) helps to distinguish bacterial from viral infection by combining the blood concentrations of three biomarkers: tumour necrosis factor related apoptosis inducing ligand (TRAIL), interferon gamma induced protein 10 (IP-10), and C-reactive protein (CRP). These host biomarkers are differentially expressed in response to bacterial versus viral acute infection. We conducted a prospective study, with a time series design, in healthy adult volunteers in the Netherlands. The aim was to determine t...
Source: Cytokine - February 2, 2024 Category: Molecular Biology Authors: Annefleur C Langedijk Katrien Oude Rengerink Eline Harding Annemarie Wensing Rianne van Slooten Yael Israeli Michal Rosenberg Tanya Gottlieb Eran Eden Louis J Bont Source Type: research
