Understanding long COVID myocarditis: A comprehensive review
Cytokine. 2024 Mar 18;178:156584. doi: 10.1016/j.cyto.2024.156584. Online ahead of print.ABSTRACTInfectious diseases are a cause of major concern in this twenty-first century. There have been reports of various outbreaks like severe acute respiratory syndrome (SARS) in 2003, swine flu in 2009, Zika virus disease in 2015, and Middle East Respiratory Syndrome (MERS) in 2012, since the start of this millennium. In addition to these outbreaks, the latest infectious disease to result in an outbreak is the SARS-CoV-2 infection. A viral infection recognized as a respiratory illness at the time of emergence, SARS-CoV-2 has wreaked...
Source: Cytokine - March 20, 2024 Category: Molecular Biology Authors: Arti Srivastava Shankar Nalroad Sundararaj Jagriti Bhatia Dharamvir Singh Arya Source Type: research
Platelet-derived sTLT-1 is associated with platelet-mediated inflammation in coronary artery disease patients
In this study, we explored the role of platelet-derived sTLT-1 in platelet-mediated inflammation in CAD patients. Plasma levels of sTLT-1 were measured using enzyme-linked immunosorbent assay in CAD patients (n = 163) and healthy controls (n = 99). Correlation analysis was performed to determine the circulatory sTLT-1 levels with platelet activation markers, immune cells, and inflammatory cytokines/chemokines. Increased plasma sTLT-1 levels were observed in CAD patients compared with those in healthy controls (p < 0.0001). A positive correlation was observed between sTLT-1 and platelet activation markers (P-selectin, PA...
Source: Cytokine - March 20, 2024 Category: Molecular Biology Authors: Amir Ali Nadella Mounika Bishamber Nath Ebin Johny Indra Kuladhipati Rajesh Das Monowar Hussain Arun Bandyopadhyay Ramu Adela Source Type: research
Serum cytokine profiles during engraftment syndrome and acute graft-versus-host disease in adult patients after hematopoietic stem cell transplantation
CONCLUSIONS: These findings suggest that cytokine profiles could serve as potential indicators for detecting and differentiating ES and aGvHD, enabling timely clinical intervention. Prospective clinical trials involving larger, independent patient cohorts are required to validate these observations.PMID:38493534 | DOI:10.1016/j.cyto.2024.156582 (Source: Cytokine)
Source: Cytokine - March 17, 2024 Category: Molecular Biology Authors: Beiying Wu Cen Jiang Lilan Jin Xiayidan Azadan Jiafei Lin Lin Lin Xiaomeng Nie Gang Cai Source Type: research
Serum cytokine profiles during engraftment syndrome and acute graft-versus-host disease in adult patients after hematopoietic stem cell transplantation
CONCLUSIONS: These findings suggest that cytokine profiles could serve as potential indicators for detecting and differentiating ES and aGvHD, enabling timely clinical intervention. Prospective clinical trials involving larger, independent patient cohorts are required to validate these observations.PMID:38493534 | DOI:10.1016/j.cyto.2024.156582 (Source: Cytokine)
Source: Cytokine - March 17, 2024 Category: Molecular Biology Authors: Beiying Wu Cen Jiang Lilan Jin Xiayidan Azadan Jiafei Lin Lin Lin Xiaomeng Nie Gang Cai Source Type: research
Serum cytokine profiles during engraftment syndrome and acute graft-versus-host disease in adult patients after hematopoietic stem cell transplantation
CONCLUSIONS: These findings suggest that cytokine profiles could serve as potential indicators for detecting and differentiating ES and aGvHD, enabling timely clinical intervention. Prospective clinical trials involving larger, independent patient cohorts are required to validate these observations.PMID:38493534 | DOI:10.1016/j.cyto.2024.156582 (Source: Cytokine)
Source: Cytokine - March 17, 2024 Category: Molecular Biology Authors: Beiying Wu Cen Jiang Lilan Jin Xiayidan Azadan Jiafei Lin Lin Lin Xiaomeng Nie Gang Cai Source Type: research
Association of adiponectin and its receptor gene polymorphisms with the risk of coronary heart disease in northern Guangxi
CONCLUSIONS: APN gene of rs266729 C/G single-nucleotide loci gene mutation can significantly increase the risk of CHD. There was no significant correlation between rs1501299 G/T single-nucleotide loci and CHD in Northern Guangxi populations.PMID:38489870 | DOI:10.1016/j.cyto.2024.156567 (Source: Cytokine)
Source: Cytokine - March 15, 2024 Category: Molecular Biology Authors: Xiaohua Xiang Di Wang Jun Leng Ning Li Chuandong Wei Source Type: research
Association of adiponectin and its receptor gene polymorphisms with the risk of coronary heart disease in northern Guangxi
CONCLUSIONS: APN gene of rs266729 C/G single-nucleotide loci gene mutation can significantly increase the risk of CHD. There was no significant correlation between rs1501299 G/T single-nucleotide loci and CHD in Northern Guangxi populations.PMID:38489870 | DOI:10.1016/j.cyto.2024.156567 (Source: Cytokine)
Source: Cytokine - March 15, 2024 Category: Molecular Biology Authors: Xiaohua Xiang Di Wang Jun Leng Ning Li Chuandong Wei Source Type: research
Genetic liability to elevated circulating IP-10, IFN γ and SCGFβ levels in relation to thoracic aortic aneurysm: A mendelian randomization study
In this study, we explored the relationship between circulating inflammatory factors and TAA risk using Mendelian randomization (MR) approach based on summary statistics from the latest genome-wide association study (GWAS) of 41 circulating inflammatory factors in 8293 Finns and a GWAS involving 1351 TAA cases and 18,295 controls of European ancestry. In univariable MR, higher interferon gamma-induced protein 10 (IP-10) levels, higher interferon gamma (IFNγ) levels and higher stem cell growth factor beta (SCGFβ) levels were associated with an increased risk of TAA (OR = 1.37, 95 % CI = 1.17-1.59, p = 7.42 × 10-5; OR = 1...
Source: Cytokine - March 14, 2024 Category: Molecular Biology Authors: Qianxi Ye Miao Chen Liang Ma Source Type: research
Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF- κB pathway
Cytokine. 2024 Mar 13;178:156578. doi: 10.1016/j.cyto.2024.156578. Online ahead of print.ABSTRACTThe present study describes the synthesis, characterization, and evaluation of tetrahydropiperine (THP), piperic acid (PA), and tetrahydropiperic acid (THPA) as anti-inflammatory agents. THPA demonstrated potent anti-inflammatory activity among all the compounds. The anti-inflammatory potential was investigated in both in-vitro and in-vivo experimental models. Our findings demonstrated that THPA effectively suppressed the production of pro-inflammatory mediators, including nitric oxide and pro-inflammatory cytokines (TNF-α, IL...
Source: Cytokine - March 14, 2024 Category: Molecular Biology Authors: Diljeet Kumar Aminur Rahman Sarkar Nusrit Iqbal Andrabi Syed Assim Haq Manzoor Ahmed Sanket Kumar Shukla Zabeer Ahmed Rajkishor Rai Source Type: research
Genetic liability to elevated circulating IP-10, IFN γ and SCGFβ levels in relation to thoracic aortic aneurysm: A mendelian randomization study
In this study, we explored the relationship between circulating inflammatory factors and TAA risk using Mendelian randomization (MR) approach based on summary statistics from the latest genome-wide association study (GWAS) of 41 circulating inflammatory factors in 8293 Finns and a GWAS involving 1351 TAA cases and 18,295 controls of European ancestry. In univariable MR, higher interferon gamma-induced protein 10 (IP-10) levels, higher interferon gamma (IFNγ) levels and higher stem cell growth factor beta (SCGFβ) levels were associated with an increased risk of TAA (OR = 1.37, 95 % CI = 1.17-1.59, p = 7.42 × 10-5; OR = 1...
Source: Cytokine - March 14, 2024 Category: Molecular Biology Authors: Qianxi Ye Miao Chen Liang Ma Source Type: research
Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF- κB pathway
Cytokine. 2024 Mar 13;178:156578. doi: 10.1016/j.cyto.2024.156578. Online ahead of print.ABSTRACTThe present study describes the synthesis, characterization, and evaluation of tetrahydropiperine (THP), piperic acid (PA), and tetrahydropiperic acid (THPA) as anti-inflammatory agents. THPA demonstrated potent anti-inflammatory activity among all the compounds. The anti-inflammatory potential was investigated in both in-vitro and in-vivo experimental models. Our findings demonstrated that THPA effectively suppressed the production of pro-inflammatory mediators, including nitric oxide and pro-inflammatory cytokines (TNF-α, IL...
Source: Cytokine - March 14, 2024 Category: Molecular Biology Authors: Diljeet Kumar Aminur Rahman Sarkar Nusrit Iqbal Andrabi Syed Assim Haq Manzoor Ahmed Sanket Kumar Shukla Zabeer Ahmed Rajkishor Rai Source Type: research
IL-4 regulates neutrophilic pulmonary inflammation in a mouse model of bronchial asthma
Cytokine. 2024 Mar 12;178:156563. doi: 10.1016/j.cyto.2024.156563. Online ahead of print.ABSTRACTNeutrophilic pulmonary inflammation in asthmatics substantially exacerbates the severity of the disease leading to resistance to conventional corticosteroid therapy. Many studies established the involvement of Th1- and Th17-cells and cytokines produced by them (IFNg, IL-17A, IL-17F etc.) in neutrophilic pulmonary inflammation. Recent studies revealed that IL-4 - a Th2-cytokine regulates neutrophil effector functions and migration. It was showed that IL-4 substantially reduces neutrophilic inflammation of the skin in a mouse mod...
Source: Cytokine - March 13, 2024 Category: Molecular Biology Authors: I P Shilovskiy A A Nikolskii E D Timotievich V I Kovchina L I Vishnyakova K V Yumashev K V Vinogradova M M Kaganova V E Brylina V V Tyulyubaev T E Rusak M E Dyneva O M Kurbacheva D A Kudlay M R Khaitov Source Type: research
Comprehensive analysis of multiple cytokines to stratify uropathogenic Escherichia coli pathogenesis in mouse model of urinary tract infection
CONCLUSION: These findings show a role of IL1β to stratify pathogenicity of UPEC in mouse UTI model.PMID:38479049 | DOI:10.1016/j.cyto.2024.156577 (Source: Cytokine)
Source: Cytokine - March 13, 2024 Category: Molecular Biology Authors: Snehashis Koley Mandira Mukherjee Source Type: research
Corrigendum to "The relationship between serum cytokine profile and vitamin D in calves with neonatal diarrhea" [Cytokine 165 (2023) 156173]
Cytokine. 2024 Mar 12:156566. doi: 10.1016/j.cyto.2024.156566. Online ahead of print.NO ABSTRACTPMID:38480034 | DOI:10.1016/j.cyto.2024.156566 (Source: Cytokine)
Source: Cytokine - March 13, 2024 Category: Molecular Biology Authors: Mehmet Çalışkan Murat Dabak Kenan Çağrı Tümer Source Type: research
IL-4 regulates neutrophilic pulmonary inflammation in a mouse model of bronchial asthma
Cytokine. 2024 Mar 12;178:156563. doi: 10.1016/j.cyto.2024.156563. Online ahead of print.ABSTRACTNeutrophilic pulmonary inflammation in asthmatics substantially exacerbates the severity of the disease leading to resistance to conventional corticosteroid therapy. Many studies established the involvement of Th1- and Th17-cells and cytokines produced by them (IFNg, IL-17A, IL-17F etc.) in neutrophilic pulmonary inflammation. Recent studies revealed that IL-4 - a Th2-cytokine regulates neutrophil effector functions and migration. It was showed that IL-4 substantially reduces neutrophilic inflammation of the skin in a mouse mod...
Source: Cytokine - March 13, 2024 Category: Molecular Biology Authors: I P Shilovskiy A A Nikolskii E D Timotievich V I Kovchina L I Vishnyakova K V Yumashev K V Vinogradova M M Kaganova V E Brylina V V Tyulyubaev T E Rusak M E Dyneva O M Kurbacheva D A Kudlay M R Khaitov Source Type: research
