Circulating cytokines levels and osteoarthritis: A Mendelian randomization study
CONCLUSIONS: Our MR analysis provides suggestive evidence of causal relationships between circulating cytokines and growth factors levels and OA, providing new insights into the etiology of OA.PMID:38677184 | DOI:10.1016/j.cyto.2024.156625 (Source: Cytokine)
Source: Cytokine - April 27, 2024 Category: Molecular Biology Authors: Jiale Xie Xianjie Wan Mingyi Yang Hui Yu Jinrong Hao Ke Xu Jiachen Wang Peng Xu Source Type: research
Association between CBL gene polymorphism and susceptibility of microscopic polyangiitis in a Chinese population: A case-control analysis
CONCLUSION: The genetic polymorphism of CBL had a potential association with the risk of MPA and clinical treatment effects in Guangxi population in China.PMID:38669907 | DOI:10.1016/j.cyto.2024.156596 (Source: Cytokine)
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Liu Liu Yan Zhu Jingjing Lan Liepeng Chu Wei Li Chao Xue Source Type: research
IL-23 regulation of myeloid cell biology during inflammation
We report that endogenous IL-23 was required for maximal macrophage activation by zymosan as determined by pro-inflammatory cytokine production, including a dramatic upregulation of granulocyte-colony stimulating factor (G-CSF). Furthermore, both IL-23p19 genetic deletion and neutralization in zymosan-induced peritonitis (ZIP) led to a specific reduction in the neutrophil numbers, as well as a reduction in the G-CSF levels in exudate fluids. We conclude that endogenous IL-23 can contribute significantly to macrophage activation during an inflammatory response, mostly likely via an autocrine/paracrine mechanism; of note, en...
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Kevin M-C Lee Tanya Lupancu Leon Chang Carl L Manthey Martha Zeeman Anne M Fourie John A Hamilton Source Type: research
Association between CBL gene polymorphism and susceptibility of microscopic polyangiitis in a Chinese population: A case-control analysis
CONCLUSION: The genetic polymorphism of CBL had a potential association with the risk of MPA and clinical treatment effects in Guangxi population in China.PMID:38669907 | DOI:10.1016/j.cyto.2024.156596 (Source: Cytokine)
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Liu Liu Yan Zhu Jingjing Lan Liepeng Chu Wei Li Chao Xue Source Type: research
IL-23 regulation of myeloid cell biology during inflammation
We report that endogenous IL-23 was required for maximal macrophage activation by zymosan as determined by pro-inflammatory cytokine production, including a dramatic upregulation of granulocyte-colony stimulating factor (G-CSF). Furthermore, both IL-23p19 genetic deletion and neutralization in zymosan-induced peritonitis (ZIP) led to a specific reduction in the neutrophil numbers, as well as a reduction in the G-CSF levels in exudate fluids. We conclude that endogenous IL-23 can contribute significantly to macrophage activation during an inflammatory response, mostly likely via an autocrine/paracrine mechanism; of note, en...
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Kevin M-C Lee Tanya Lupancu Leon Chang Carl L Manthey Martha Zeeman Anne M Fourie John A Hamilton Source Type: research
Diagnostic accuracy and cellular origin of pleural fluid CXCR3 ligands for tuberculous pleural effusion
CONCLUSIONS: Pleural CXCL9 and CXCL11 are potential diagnostic markers for TPE, but their diagnostic accuracy is compromised in elderly patients. CXCL9 and CXCL11 can promote the migration of peripheral Th cells, thus representing a therapeutic target for the treatment of TPE.PMID:38663252 | DOI:10.1016/j.cyto.2024.156618 (Source: Cytokine)
Source: Cytokine - April 25, 2024 Category: Molecular Biology Authors: Zhi Yan Jian-Xun Wen Yan Niu Ting-Wang Jiang Jin-Hong Huang Hong Chen Qi Chen Ya-Fei Wang Li Yan Zhi-De Hu Wen-Qi Zheng Source Type: research
Diagnostic accuracy and cellular origin of pleural fluid CXCR3 ligands for tuberculous pleural effusion
CONCLUSIONS: Pleural CXCL9 and CXCL11 are potential diagnostic markers for TPE, but their diagnostic accuracy is compromised in elderly patients. CXCL9 and CXCL11 can promote the migration of peripheral Th cells, thus representing a therapeutic target for the treatment of TPE.PMID:38663252 | DOI:10.1016/j.cyto.2024.156618 (Source: Cytokine)
Source: Cytokine - April 25, 2024 Category: Molecular Biology Authors: Zhi Yan Jian-Xun Wen Yan Niu Ting-Wang Jiang Jin-Hong Huang Hong Chen Qi Chen Ya-Fei Wang Li Yan Zhi-De Hu Wen-Qi Zheng Source Type: research
Immune profiles of MCP-1 with M tb antigens and recombinant cytokines stimulation in tuberculosis
In conclusion, the study determined the differential expression and production of MCP-1 with M tb antigens and recombinant cytokines. Further, cohort studies are required to study these interaction to identify the high risk individuals, which might help for TB control.PMID:38648681 | DOI:10.1016/j.cyto.2024.156622 (Source: Cytokine)
Source: Cytokine - April 22, 2024 Category: Molecular Biology Authors: Ashwini Pullagurla Bhagyalaxmi Rapolu Shazia Ahmad Sumanlatha Gaddam Source Type: research
Microalgae extracts modulates the immune response in Trypanosoma cruzi-infected human cells
This study aimed to evaluate, in vitro, immunomodulatory potentials of the aqueous extracts of Chlorella vulgaris and Tetradesmus obliquus. Both microalgae extracts (ME) were obtained by sonication, and the selectivity index (SI) was determined by assays of inhibitory concentration (IC50) in T. cruzi trypomastigotes cells; as well as the cytotoxic concentrations (CC50) in human peripheral mononuclear cells (PBMC). The immune response was evaluated in T. cruzi-infected PBMC using the IC50 value. ME led to inhibition of T. cruzi trypomastigotes after 24 h of treatment, in which the IC50 values were 112.1 µg/ml to C. vulgari...
Source: Cytokine - April 22, 2024 Category: Molecular Biology Authors: Jos é Noé da Silva Júnior Kamila Kassia Dos Santos Oliveira Ana Carla da Silva Virginia Maria Barros de Lorena Daniela de Ara újo Viana Marques Raquel Pedrosa Bezerra Ana L úcia Figueiredo Porto Source Type: research
Immune profiles of MCP-1 with M tb antigens and recombinant cytokines stimulation in tuberculosis
In conclusion, the study determined the differential expression and production of MCP-1 with M tb antigens and recombinant cytokines. Further, cohort studies are required to study these interaction to identify the high risk individuals, which might help for TB control.PMID:38648681 | DOI:10.1016/j.cyto.2024.156622 (Source: Cytokine)
Source: Cytokine - April 22, 2024 Category: Molecular Biology Authors: Ashwini Pullagurla Bhagyalaxmi Rapolu Shazia Ahmad Sumanlatha Gaddam Source Type: research
Microalgae extracts modulates the immune response in Trypanosoma cruzi-infected human cells
This study aimed to evaluate, in vitro, immunomodulatory potentials of the aqueous extracts of Chlorella vulgaris and Tetradesmus obliquus. Both microalgae extracts (ME) were obtained by sonication, and the selectivity index (SI) was determined by assays of inhibitory concentration (IC50) in T. cruzi trypomastigotes cells; as well as the cytotoxic concentrations (CC50) in human peripheral mononuclear cells (PBMC). The immune response was evaluated in T. cruzi-infected PBMC using the IC50 value. ME led to inhibition of T. cruzi trypomastigotes after 24 h of treatment, in which the IC50 values were 112.1 µg/ml to C. vulgari...
Source: Cytokine - April 22, 2024 Category: Molecular Biology Authors: Jos é Noé da Silva Júnior Kamila Kassia Dos Santos Oliveira Ana Carla da Silva Virginia Maria Barros de Lorena Daniela de Ara újo Viana Marques Raquel Pedrosa Bezerra Ana L úcia Figueiredo Porto Source Type: research
Association of IL-6-572 polymorphism with sepsis: An updated meta-analysis
CONCLUSION: According to the meta-analysis results of existing studies, the IL-6 572C/G GG genotype and G allele are risk factors for sepsis, this result changes the previous conclusion that the IL-6 572 polymorphism is not related to sepsis. However, the results still need to be conservatively treated due to the sample size was not large enough.PMID:38643631 | DOI:10.1016/j.cyto.2024.156597 (Source: Cytokine)
Source: Cytokine - April 21, 2024 Category: Molecular Biology Authors: Fang Hou Jing Gao Li Zhang Chang Liu Source Type: research
Transcriptome of bone marrow-Derived stem cells reveals new inflammatory mediators related to increased survival in patients with multiple myeloma
Cytokine. 2024 Apr 20;179:156613. doi: 10.1016/j.cyto.2024.156613. Online ahead of print.ABSTRACTAlthough multiple myeloma (MM) is a neoplasm that leads affected individuals to death, little is known about why some patients survive much longer than others. In this context, we investigated the transcriptomic profile of bone marrow hematopoietic stem cells obtained from MM patients and compared the clinical outcomes of death and survival six months after bone marrow transplantation. The leukapheresis products of 39 patients with MM eligible for autologous transplantation were collected and analyzed. After extraction, the RNA...
Source: Cytokine - April 21, 2024 Category: Molecular Biology Authors: Stefania Tagliari de Oliveira Renata Binato Geise Ellen Broto Erika Tomie Takakura Leticia Navarro Gordan Ferreira Martins Eliana Abdelhay Carolina Panis Source Type: research
Immune responses induced by Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) upon co-administration with Bacillus Calmette-Gu érin in mice
CONCLUSION: We demonstrated that HAg has favourable immunogenicity, triggers a stronger Th1-type immune response and proposed the hypothesis that HAg can be used as a BCG booster to further enhance the benefits of BCG.PMID:38640558 | DOI:10.1016/j.cyto.2024.156610 (Source: Cytokine)
Source: Cytokine - April 19, 2024 Category: Molecular Biology Authors: Fangzheng Guo Jing Wei Yamin Song Jianhan Song Ying Wang Kangsheng Li Baiqing Li Zhongqing Qian Xiaojing Wang Hongtao Wang Tao Xu Source Type: research
Immune response to colonization of Candida albicans in mice treated with Cefoperazone
In conclusion, this study demonstrated that cefoperazone treatment and infection by Candida albicans changed the microbiome components in the gut and finally can change host immune responses. It was observed that elevated levels of the antibodies production (IgA and IgG) and immunological markers (IL-17, and TLR2) in serum and the gut.PMID:38640559 | DOI:10.1016/j.cyto.2024.156611 (Source: Cytokine)
Source: Cytokine - April 19, 2024 Category: Molecular Biology Authors: Hussein Muttaleb Asfoor Atyaf Saied Hamied Source Type: research
