Changes in markers of inflammation and their correlation with death in patients with COVID-19 in the intensive care unit
This study aimed to characterize the changes in serum inflammatory mediators in hospitalized patients with COVID-19 correlating with death. The study includes 58 participants: i) inpatients (n = 37): patients suffering from severe acute respiratory syndrome due to COVID-19, who were admitted at Intensive Care Unit (ICU) recovered and who died and ii) control group (n = 21): community volunteers. Inflammatory mediators evaluated interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-17 (IL-17), interferon-gamma (IFN-γ) and interferon-gamma protein levels (IFN-γ), as well as, ...
Source: Cytokine - January 19, 2024 Category: Molecular Biology Authors: Andressa de Azambuja Pias Weber Fernanda Tibolla Viero Micheli Mainardi Pillat Thissiane de Lima Gon çalves Source Type: research
The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4 < sup > + < /sup > T cells
This study demonstrated the impact of PHF2 on cytokine production in CD4+ T cells for the first time. Further studies on the PHF2-mediated epigenetic mechanisms may lead to the development of treatments for a variety of immune diseases.PMID:38241965 | DOI:10.1016/j.cyto.2024.156506 (Source: Cytokine)
Source: Cytokine - January 19, 2024 Category: Molecular Biology Authors: Yuya Arakawa Yuzuki Tano Moe Fujii Yuuki Imai Yoshiaki Norimatsu Masaki Yasukawa Mikio Watanabe Takeshi Yamada Source Type: research
Soluble urate-induced effects on cytokine production in vitro - Assessment of methodologies and cell types
CONCLUSIONS: Overall, the urate dissolving methods do not have critical impact on its inflammatory properties. Soluble urate prepared using either of the two methods showed mostly pro-inflammatory effects on human primary PBMCs and monocytic cell line THP-1. However, human primary PBMCs and the THP-1 differ in their response to soluble urate without restimulation.PMID:38237388 | DOI:10.1016/j.cyto.2024.156502 (Source: Cytokine)
Source: Cytokine - January 18, 2024 Category: Molecular Biology Authors: Ruiqi Liu Viola Kl ück Brenda Kischkel Helin Tercan Mihai G Netea Tania O Cri şan Leo A B Joosten Source Type: research
Radix Tetrastigma Hemsleyani Flavone represses cutaneous squamous cell carcinoma via Janus kinase/signal transducer and activator of transcription 3 pathway inactivation
Cytokine. 2024 Mar;175:156480. doi: 10.1016/j.cyto.2023.156480. Epub 2024 Jan 17.ABSTRACTCutaneous squamous cell carcinoma (CSCC) is the second most common malignant skin tumor and significantly affects patients' quality of life and health. The Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway activation is involved in CSCC development. Radix Tetrastigma hemsleyani flavone (RTHF) is an active Radix Tetrastigma extract (RTE), which was recently reported to have promising inhibitory effects on CSCC. However, the underlying functional mechanisms of this inhibition remain unknown. In the prese...
Source: Cytokine - January 17, 2024 Category: Molecular Biology Authors: Jianzhong Peng Xianyan Luo Tao Wang Chao Yue Mengying Duan Chenyang Wu Source Type: research
Investigation of the linkage between TNF-alfa rs1800629 polymorphism and preeclampsia risk: A meta-analysis
CONCLUSION: Overall, the present meta-analysis explored a consistent linkage of the TNF-alfa rs1800629 variant to the preeclampsia risk in different ethnic groups. Additional research is required to confirm the precise relationship between the rs1800629 variant and preeclampsia risk.PMID:38199085 | DOI:10.1016/j.cyto.2024.156499 (Source: Cytokine)
Source: Cytokine - January 10, 2024 Category: Molecular Biology Authors: Md Shafiul Hossen Md Abdul Aziz Md Abdul Barek Mohammad Safiqul Islam Source Type: research
Interaction between cardiac resynchronization therapy and cytokines in heart failure patients
In this study, we have reviewed the immunological processes involved in heart failure and the effect of CRT in controlling of the cytokine storm.PMID:38199086 | DOI:10.1016/j.cyto.2023.156479 (Source: Cytokine)
Source: Cytokine - January 10, 2024 Category: Molecular Biology Authors: Seyyed Shamsadin Athari Entezar Mehrabi Nasab Kai Jing Jin Wang Source Type: research
Do chemokine/chemokine receptor axes play paramount parts in trafficking and oriented locomotion of monocytes/macrophages toward the lungs of COVID-19 infected patients? A systematic review
Cytokine. 2024 Mar;175:156497. doi: 10.1016/j.cyto.2023.156497. Epub 2024 Jan 7.ABSTRACTThe COVID-19 (coronavirus disease 2019) is a well-defined viral infection, resulting from SARS-CoV-2 (severe acute respiratory syndrome- coronavirus-2). The innate immune system serves as the first line of defense to limit viral spreading and subsequently stimulate adaptive immune responses by the prominent aids of its cellular and molecular arms. Monocytes are defined as the most prominent innate immune cells (IICs) that are reactive against invading pathogens. These cells support host protection against the virus that is mediated by s...
Source: Cytokine - January 8, 2024 Category: Molecular Biology Authors: Merat Mahmoodi Fatemeh Mohammadi Henjeroei Gholamhossein Hassanshahi Reza Nosratabadi Source Type: research
Do chemokine/chemokine receptor axes play paramount parts in trafficking and oriented locomotion of monocytes/macrophages toward the lungs of COVID-19 infected patients? A systematic review
Cytokine. 2024 Jan 7;175:156497. doi: 10.1016/j.cyto.2023.156497. Online ahead of print.ABSTRACTThe COVID-19 (coronavirus disease 2019) is a well-defined viral infection, resulting from SARS-CoV-2 (severe acute respiratory syndrome- coronavirus-2). The innate immune system serves as the first line of defense to limit viral spreading and subsequently stimulate adaptive immune responses by the prominent aids of its cellular and molecular arms. Monocytes are defined as the most prominent innate immune cells (IICs) that are reactive against invading pathogens. These cells support host protection against the virus that is media...
Source: Cytokine - January 8, 2024 Category: Molecular Biology Authors: Merat Mahmoodi Fatemeh Mohammadi Henjeroei Gholamhossein Hassanshahi Reza Nosratabadi Source Type: research
Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients
This study aimed to comparatively investigate the relationship between lncRNAs (eosinophil granule ontogeny transcript (EGOT), negative regulator of antiviral response (NRAV), and negative regulator of interferon response (NRIR)), alongside interferon-stimulated genes (ISGs) like ISG-15 and interferon-induced transmembrane protein 3 (IFITM3) in COVID-19 patients with asymptomatic, moderate, and severe symptoms. Buffy coat samples were collected from 17 asymptomatic, 23 moderate, 22 severe patients, and 44 healthy controls. Quantitative real-time PCR was utilized to determine the expression levels. In a comparison between C...
Source: Cytokine - January 7, 2024 Category: Molecular Biology Authors: Zahra Sefatjoo Seyed Reza Mohebbi Seyed Masoud Hosseini Shahrzad Shoraka Mahsa Saeedi Niasar Kaveh Baghaei Anna Meyfour Amir Sadeghi Habib Malekpour Hamid Asadzadeh Aghdaei Mohammad Reza Zali Source Type: research
Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients
This study aimed to comparatively investigate the relationship between lncRNAs (eosinophil granule ontogeny transcript (EGOT), negative regulator of antiviral response (NRAV), and negative regulator of interferon response (NRIR)), alongside interferon-stimulated genes (ISGs) like ISG-15 and interferon-induced transmembrane protein 3 (IFITM3) in COVID-19 patients with asymptomatic, moderate, and severe symptoms. Buffy coat samples were collected from 17 asymptomatic, 23 moderate, 22 severe patients, and 44 healthy controls. Quantitative real-time PCR was utilized to determine the expression levels. In a comparison between C...
Source: Cytokine - January 7, 2024 Category: Molecular Biology Authors: Zahra Sefatjoo Seyed Reza Mohebbi Seyed Masoud Hosseini Shahrzad Shoraka Mahsa Saeedi Niasar Kaveh Baghaei Anna Meyfour Amir Sadeghi Habib Malekpour Hamid Asadzadeh Aghdaei Mohammad Reza Zali Source Type: research
Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis
Cytokine. 2024 Jan 3;175:156498. doi: 10.1016/j.cyto.2024.156498. Online ahead of print.ABSTRACTS. aureus isolated from bacterial bovine endometritis is common in epidemiological reports, but is often ignored as a subclinical pathogenic microorganism. In a previous study, we showed that live S. aureus (LSA) and heat killed S. aureus (HK-SA) induce different inflammatory responses in bovine endometrial tissue, and possibly being associated with the accumulation of prostaglandin E2 (PGE2). Thus, in this study, we varied PGE2 concentrations using inhibitors or agonists in HK-SA-treated bovine endometrial tissues. The results ...
Source: Cytokine - January 4, 2024 Category: Molecular Biology Authors: Kun Liu Le Pei Yuan Shen Jindi Wu Yinghong Qian Nan Zhang Wei Mao Jinshan Cao Source Type: research
Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis
Cytokine. 2024 Jan 3;175:156498. doi: 10.1016/j.cyto.2024.156498. Online ahead of print.ABSTRACTS. aureus isolated from bacterial bovine endometritis is common in epidemiological reports, but is often ignored as a subclinical pathogenic microorganism. In a previous study, we showed that live S. aureus (LSA) and heat killed S. aureus (HK-SA) induce different inflammatory responses in bovine endometrial tissue, and possibly being associated with the accumulation of prostaglandin E2 (PGE2). Thus, in this study, we varied PGE2 concentrations using inhibitors or agonists in HK-SA-treated bovine endometrial tissues. The results ...
Source: Cytokine - January 4, 2024 Category: Molecular Biology Authors: Kun Liu Le Pei Yuan Shen Jindi Wu Yinghong Qian Nan Zhang Wei Mao Jinshan Cao Source Type: research
Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis
Cytokine. 2024 Jan 3;175:156498. doi: 10.1016/j.cyto.2024.156498. Online ahead of print.ABSTRACTS. aureus isolated from bacterial bovine endometritis is common in epidemiological reports, but is often ignored as a subclinical pathogenic microorganism. In a previous study, we showed that live S. aureus (LSA) and heat killed S. aureus (HK-SA) induce different inflammatory responses in bovine endometrial tissue, and possibly being associated with the accumulation of prostaglandin E2 (PGE2). Thus, in this study, we varied PGE2 concentrations using inhibitors or agonists in HK-SA-treated bovine endometrial tissues. The results ...
Source: Cytokine - January 4, 2024 Category: Molecular Biology Authors: Kun Liu Le Pei Yuan Shen Jindi Wu Yinghong Qian Nan Zhang Wei Mao Jinshan Cao Source Type: research
Improvements in markers of inflammation and coagulation potential following a 5-day high-fat diet rich in cottonseed oil vs. Olive oil in healthy males
CONCLUSION: A 5-day, CSO-enriched diet may be sufficient to reduce inflammation and coagulation potential compared to OO-enriched diets in a healthy male population which could have implications in chronic disease prevention.PMID:38171039 | DOI:10.1016/j.cyto.2023.156494 (Source: Cytokine)
Source: Cytokine - January 3, 2024 Category: Molecular Biology Authors: M Catherine Prater Kristine R Polley Jamie A Cooper Source Type: research
Improvements in markers of inflammation and coagulation potential following a 5-day high-fat diet rich in cottonseed oil vs. Olive oil in healthy males
CONCLUSION: A 5-day, CSO-enriched diet may be sufficient to reduce inflammation and coagulation potential compared to OO-enriched diets in a healthy male population which could have implications in chronic disease prevention.PMID:38171039 | DOI:10.1016/j.cyto.2023.156494 (Source: Cytokine)
Source: Cytokine - January 3, 2024 Category: Molecular Biology Authors: M Catherine Prater Kristine R Polley Jamie A Cooper Source Type: research
