Soluble urate-induced effects on cytokine production in vitro - Assessment of methodologies and cell types

CONCLUSIONS: Overall, the urate dissolving methods do not have critical impact on its inflammatory properties. Soluble urate prepared using either of the two methods showed mostly pro-inflammatory effects on human primary PBMCs and monocytic cell line THP-1. However, human primary PBMCs and the THP-1 differ in their response to soluble urate without restimulation.PMID:38237388 | DOI:10.1016/j.cyto.2024.156502

Source: Cytokine - January 18, 2024 Category: Molecular Biology Authors: Ruiqi Liu Viola Kl ück Brenda Kischkel Helin Tercan Mihai G Netea Tania O Cri şan Leo A B Joosten Source Type: research