Association between NOS3 gene polymorphisms and genetic susceptibility to congenital heart Disease: A systematic review and meta-analysis
CONCLUSION: rs1799983 (G894T) and rs7830 (G10T) polymorphic sites might play a role in the susceptibility of sporadic congenital heart disease and increase the risk of CHD. Yet, it is still necessary to expand the sample size and conduct more prospective/retrospective studies to confirm whether the rs2070744 (T-786C) polymorphism tended to increase the incidence of CHD.PMID:37952311 | DOI:10.1016/j.cyto.2023.156415 (Source: Cytokine)
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Kang Yi Wei Wang Xin Zhang Xin Dong Zhengye Fan Yuhu Ma Jie Gao Xinyao Li Tao You Source Type: research
Non-coding RNAs involved in fibroblast-like synoviocyte functioning in arthritis rheumatoid: From pathogenesis to therapy
Cytokine. 2023 Nov 10;173:156418. doi: 10.1016/j.cyto.2023.156418. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a polygenic autoimmune disorder with an uncertain etiology, primarily impacting the joints. Moreover, the disease may manifest beyond articular involvement, leading to extra-articular manifestations. Fibroblast-like synoviocytes (FLS) are cells of mesenchymal origin that possess crucial physiological significance within the synovium, contributing to the synthesis of specific constituents found in the synovial fluid and articular cartilage. Consequently, there has been a growing focus on FLS as a pot...
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Yuwei Peng Meng Zhang Jiangkang Hu Source Type: research
Growth hormone-releasing hormone antagonists counteract interferon- γ - induced barrier dysfunction in bovine and human endothelial cells
Cytokine. 2023 Nov 10;173:156416. doi: 10.1016/j.cyto.2023.156416. Online ahead of print.ABSTRACTGHRH regulates the secretion of GH from the anterior pituitary gland. An emerging body of evidence suggests that the activities of that neuropeptide are not limited to the GH/IGF-I axis, but they expand towards the mediation of inflammatory processes. GHRHAnt were developed to oppose the activities of GHRH in malignancies, and have been associated with strong anti-inflammatory and anti-oxidative effects in a diverse variety of tissues, including the lungs. In the present study we report that GHRHAnt oppose interferon-γ - induc...
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Saikat Fakir Nektarios Barabutis Source Type: research
Association between NOS3 gene polymorphisms and genetic susceptibility to congenital heart Disease: A systematic review and meta-analysis
CONCLUSION: rs1799983 (G894T) and rs7830 (G10T) polymorphic sites might play a role in the susceptibility of sporadic congenital heart disease and increase the risk of CHD. Yet, it is still necessary to expand the sample size and conduct more prospective/retrospective studies to confirm whether the rs2070744 (T-786C) polymorphism tended to increase the incidence of CHD.PMID:37952311 | DOI:10.1016/j.cyto.2023.156415 (Source: Cytokine)
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Kang Yi Wei Wang Xin Zhang Xin Dong Zhengye Fan Yuhu Ma Jie Gao Xinyao Li Tao You Source Type: research
Non-coding RNAs involved in fibroblast-like synoviocyte functioning in arthritis rheumatoid: From pathogenesis to therapy
Cytokine. 2023 Nov 10;173:156418. doi: 10.1016/j.cyto.2023.156418. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a polygenic autoimmune disorder with an uncertain etiology, primarily impacting the joints. Moreover, the disease may manifest beyond articular involvement, leading to extra-articular manifestations. Fibroblast-like synoviocytes (FLS) are cells of mesenchymal origin that possess crucial physiological significance within the synovium, contributing to the synthesis of specific constituents found in the synovial fluid and articular cartilage. Consequently, there has been a growing focus on FLS as a pot...
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Yuwei Peng Meng Zhang Jiangkang Hu Source Type: research
Growth hormone-releasing hormone antagonists counteract interferon- γ - induced barrier dysfunction in bovine and human endothelial cells
Cytokine. 2023 Nov 10;173:156416. doi: 10.1016/j.cyto.2023.156416. Online ahead of print.ABSTRACTGHRH regulates the secretion of GH from the anterior pituitary gland. An emerging body of evidence suggests that the activities of that neuropeptide are not limited to the GH/IGF-I axis, but they expand towards the mediation of inflammatory processes. GHRHAnt were developed to oppose the activities of GHRH in malignancies, and have been associated with strong anti-inflammatory and anti-oxidative effects in a diverse variety of tissues, including the lungs. In the present study we report that GHRHAnt oppose interferon-γ - induc...
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Saikat Fakir Nektarios Barabutis Source Type: research
Association between NOS3 gene polymorphisms and genetic susceptibility to congenital heart Disease: A systematic review and meta-analysis
CONCLUSION: rs1799983 (G894T) and rs7830 (G10T) polymorphic sites might play a role in the susceptibility of sporadic congenital heart disease and increase the risk of CHD. Yet, it is still necessary to expand the sample size and conduct more prospective/retrospective studies to confirm whether the rs2070744 (T-786C) polymorphism tended to increase the incidence of CHD.PMID:37952311 | DOI:10.1016/j.cyto.2023.156415 (Source: Cytokine)
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Kang Yi Wei Wang Xin Zhang Xin Dong Zhengye Fan Yuhu Ma Jie Gao Xinyao Li Tao You Source Type: research
Non-coding RNAs involved in fibroblast-like synoviocyte functioning in arthritis rheumatoid: From pathogenesis to therapy
Cytokine. 2023 Nov 10;173:156418. doi: 10.1016/j.cyto.2023.156418. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a polygenic autoimmune disorder with an uncertain etiology, primarily impacting the joints. Moreover, the disease may manifest beyond articular involvement, leading to extra-articular manifestations. Fibroblast-like synoviocytes (FLS) are cells of mesenchymal origin that possess crucial physiological significance within the synovium, contributing to the synthesis of specific constituents found in the synovial fluid and articular cartilage. Consequently, there has been a growing focus on FLS as a pot...
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Yuwei Peng Meng Zhang Jiangkang Hu Source Type: research
Growth hormone-releasing hormone antagonists counteract interferon- γ - induced barrier dysfunction in bovine and human endothelial cells
Cytokine. 2023 Nov 10;173:156416. doi: 10.1016/j.cyto.2023.156416. Online ahead of print.ABSTRACTGHRH regulates the secretion of GH from the anterior pituitary gland. An emerging body of evidence suggests that the activities of that neuropeptide are not limited to the GH/IGF-I axis, but they expand towards the mediation of inflammatory processes. GHRHAnt were developed to oppose the activities of GHRH in malignancies, and have been associated with strong anti-inflammatory and anti-oxidative effects in a diverse variety of tissues, including the lungs. In the present study we report that GHRHAnt oppose interferon-γ - induc...
Source: Cytokine - November 12, 2023 Category: Molecular Biology Authors: Saikat Fakir Nektarios Barabutis Source Type: research
Leishmania antigens activated CD4 < sup > + < /sup > T cells expressing CD200R receptors are the prime IL-10 producing phenotype and an important determinant of visceral leishmaniasis pathogenesis
In this study, we reveal that antigen-activated CD4+ T cells, i.e., CD44+CD4+ T cells expressing CD200R receptors, are the prime IL-10-producing phenotypes in Leishmania donovani infection-induced pathogenesis. These phenotypes are separate from CD25+Foxp3+CD4+ T regulatory cells, which are classical IL-10-producing phenotypes. In order to ascertain the role of CD200R and CD25 receptors in IL-10 overexpression-associated VL pathogenesis, we abrogated CD200R and CD25 receptor-mediated signaling in the infected mice. The splenic load of parasites and the size of the liver and spleen were significantly reduced in CD200-blocke...
Source: Cytokine - November 11, 2023 Category: Molecular Biology Authors: Abhishek Singh Baishakhi Mahapatra Arpita Banerjee Samer Singh Sangram Singh Vikash K Dubey Pradeep Das Rakesh K Singh Source Type: research
Leishmania antigens activated CD4 < sup > + < /sup > T cells expressing CD200R receptors are the prime IL-10 producing phenotype and an important determinant of visceral leishmaniasis pathogenesis
In this study, we reveal that antigen-activated CD4+ T cells, i.e., CD44+CD4+ T cells expressing CD200R receptors, are the prime IL-10-producing phenotypes in Leishmania donovani infection-induced pathogenesis. These phenotypes are separate from CD25+Foxp3+CD4+ T regulatory cells, which are classical IL-10-producing phenotypes. In order to ascertain the role of CD200R and CD25 receptors in IL-10 overexpression-associated VL pathogenesis, we abrogated CD200R and CD25 receptor-mediated signaling in the infected mice. The splenic load of parasites and the size of the liver and spleen were significantly reduced in CD200-blocke...
Source: Cytokine - November 11, 2023 Category: Molecular Biology Authors: Abhishek Singh Baishakhi Mahapatra Arpita Banerjee Samer Singh Sangram Singh Vikash K Dubey Pradeep Das Rakesh K Singh Source Type: research
Role of cGAS-STING in colorectal cancer: A new window for treatment strategies
Cytokine. 2023 Nov 8;173:156422. doi: 10.1016/j.cyto.2023.156422. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a common and deadly form of cancer, leading to the need for new therapeutic targets and strategies for treatment. Recent studies have shown the cGAS-STING pathway to be a promising target for cancer therapy. The cGAS-STING pathway is a part of the innate immune system and serves to identify DNA damage and viral infection, promoting an immune response. Activation of this pathway leads to the production of immune mediators, such as type I interferons, that activate immune cells to attack cancer cells. Re...
Source: Cytokine - November 10, 2023 Category: Molecular Biology Authors: Milad Khorasani Source Type: research
RNA-Seq analysis of long non-coding RNA in human intestinal epithelial cells infected by Shiga toxin-producing Escherichia coli
CONCLUSION: Our results, for the first time, revealed differentially expressed lncRNAs induced by STEC infection of HIECs. The results will help investigate the molecular mechanisms for the inflammatory responses induced by STEC.PMID:37944420 | DOI:10.1016/j.cyto.2023.156421 (Source: Cytokine)
Source: Cytokine - November 9, 2023 Category: Molecular Biology Authors: Liuqing Zhang Xuelian Ma Panpan Tong Baili Zheng Mingyue Zhu Bin Peng Jinquan Wang Yingyu Liu Source Type: research
Hematopoietic colony-stimulating factors in head and neck cancers: Recent advances and therapeutic challenges
This article provides an in-depth review of the role of hematopoietic cytokines such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interleukin-3 (IL-3; also known as multi-CSF) in the HNCs tumor microenvironment. We have reviewed current results from clinical trials using CSFs as adjuvant therapy to treat HNCs patients, and also clinical findings reported to date on the therapeutic application of CSFs toxicities arising from chemoradiotherapy.PMID:37944421 | DOI:10.1016/j.cyto.2023.156417 (Source: Cytokine)
Source: Cytokine - November 9, 2023 Category: Molecular Biology Authors: Gustavo de Souza Vieira Talita de Carvalho Kimura Jo ão Figueira Scarini Reydson Alcides de Lima-Souza Luccas Lavareze Carolina Emerick Mayara Trevizol Gon çalves Ingrid Iara Damas Tayn á Figueiredo-Maciel Raisa Sales de S á Iara Gon çalves Aquino Jo Source Type: research
RNA-Seq analysis of long non-coding RNA in human intestinal epithelial cells infected by Shiga toxin-producing Escherichia coli
CONCLUSION: Our results, for the first time, revealed differentially expressed lncRNAs induced by STEC infection of HIECs. The results will help investigate the molecular mechanisms for the inflammatory responses induced by STEC.PMID:37944420 | DOI:10.1016/j.cyto.2023.156421 (Source: Cytokine)
Source: Cytokine - November 9, 2023 Category: Molecular Biology Authors: Liuqing Zhang Xuelian Ma Panpan Tong Baili Zheng Mingyue Zhu Bin Peng Jinquan Wang Yingyu Liu Source Type: research
