Hematopoietic colony-stimulating factors in head and neck cancers: Recent advances and therapeutic challenges

This article provides an in-depth review of the role of hematopoietic cytokines such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interleukin-3 (IL-3; also known as multi-CSF) in the HNCs tumor microenvironment. We have reviewed current results from clinical trials using CSFs as adjuvant therapy to treat HNCs patients, and also clinical findings reported to date on the therapeutic application of CSFs toxicities arising from chemoradiotherapy.PMID:37944421 | DOI:10.1016/j.cyto.2023.156417

Source: Cytokine - November 9, 2023 Category: Molecular Biology Authors: Gustavo de Souza Vieira Talita de Carvalho Kimura Jo ão Figueira Scarini Reydson Alcides de Lima-Souza Luccas Lavareze Carolina Emerick Mayara Trevizol Gon çalves Ingrid Iara Damas Tayn á Figueiredo-Maciel Raisa Sales de S á Iara Gon çalves Aquino Jo Source Type: research