The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional Mendelian-randomization study
CONCLUSION: Our study unearths potential associations between systemic inflammatory modulators and common CRDs, providing new insights for inflammation-mediated CRD prevention and therapeutic approaches.PMID:38071841 | DOI:10.1016/j.cyto.2023.156470 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Guanyu Jiang Weici Liu Xiaokun Wang Zifeng Wang Chenghu Song Ruo Chen Zhao He Huixing Li Mingfeng Zheng Wenjun Mao Source Type: research
Impact of Bifidobacterium longum1714 ® on maternal cytokine response in peripheral blood mononuclear cells
CONCLUSION: Maternal antenatal supplementation with B. longum 1714 did not alter cytokine production by maternal PBMCs in response to PAMPs or anti-CD3/28/2.TRIAL REGISTRATION NUMBER: ISRCTN registry ISRCTN43013285.PMID:38071842 | DOI:10.1016/j.cyto.2023.156458 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Sarah Louise Killeen Grace Mealy Kiva Brennan Paul D Cotter Cara Yelverton Radka Saldova David Groeger Douwe VanSinderen Sarah Doyle Fionnuala M McAuliffe Source Type: research
The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional Mendelian-randomization study
CONCLUSION: Our study unearths potential associations between systemic inflammatory modulators and common CRDs, providing new insights for inflammation-mediated CRD prevention and therapeutic approaches.PMID:38071841 | DOI:10.1016/j.cyto.2023.156470 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Guanyu Jiang Weici Liu Xiaokun Wang Zifeng Wang Chenghu Song Ruo Chen Zhao He Huixing Li Mingfeng Zheng Wenjun Mao Source Type: research
Impact of Bifidobacterium longum1714 ® on maternal cytokine response in peripheral blood mononuclear cells
CONCLUSION: Maternal antenatal supplementation with B. longum 1714 did not alter cytokine production by maternal PBMCs in response to PAMPs or anti-CD3/28/2.TRIAL REGISTRATION NUMBER: ISRCTN registry ISRCTN43013285.PMID:38071842 | DOI:10.1016/j.cyto.2023.156458 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Sarah Louise Killeen Grace Mealy Kiva Brennan Paul D Cotter Cara Yelverton Radka Saldova David Groeger Douwe VanSinderen Sarah Doyle Fionnuala M McAuliffe Source Type: research
The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional Mendelian-randomization study
CONCLUSION: Our study unearths potential associations between systemic inflammatory modulators and common CRDs, providing new insights for inflammation-mediated CRD prevention and therapeutic approaches.PMID:38071841 | DOI:10.1016/j.cyto.2023.156470 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Guanyu Jiang Weici Liu Xiaokun Wang Zifeng Wang Chenghu Song Ruo Chen Zhao He Huixing Li Mingfeng Zheng Wenjun Mao Source Type: research
Impact of Bifidobacterium longum1714 ® on maternal cytokine response in peripheral blood mononuclear cells
CONCLUSION: Maternal antenatal supplementation with B. longum 1714 did not alter cytokine production by maternal PBMCs in response to PAMPs or anti-CD3/28/2.TRIAL REGISTRATION NUMBER: ISRCTN registry ISRCTN43013285.PMID:38071842 | DOI:10.1016/j.cyto.2023.156458 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Sarah Louise Killeen Grace Mealy Kiva Brennan Paul D Cotter Cara Yelverton Radka Saldova David Groeger Douwe VanSinderen Sarah Doyle Fionnuala M McAuliffe Source Type: research
The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional Mendelian-randomization study
CONCLUSION: Our study unearths potential associations between systemic inflammatory modulators and common CRDs, providing new insights for inflammation-mediated CRD prevention and therapeutic approaches.PMID:38071841 | DOI:10.1016/j.cyto.2023.156470 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Guanyu Jiang Weici Liu Xiaokun Wang Zifeng Wang Chenghu Song Ruo Chen Zhao He Huixing Li Mingfeng Zheng Wenjun Mao Source Type: research
Impact of Bifidobacterium longum1714 ® on maternal cytokine response in peripheral blood mononuclear cells
CONCLUSION: Maternal antenatal supplementation with B. longum 1714 did not alter cytokine production by maternal PBMCs in response to PAMPs or anti-CD3/28/2.TRIAL REGISTRATION NUMBER: ISRCTN registry ISRCTN43013285.PMID:38071842 | DOI:10.1016/j.cyto.2023.156458 (Source: Cytokine)
Source: Cytokine - December 10, 2023 Category: Molecular Biology Authors: Sarah Louise Killeen Grace Mealy Kiva Brennan Paul D Cotter Cara Yelverton Radka Saldova David Groeger Douwe VanSinderen Sarah Doyle Fionnuala M McAuliffe Source Type: research
Aberrant expression of SOCS impairs the anti-leishmanial immune response
Cytokine. 2023 Dec 7;174:156461. doi: 10.1016/j.cyto.2023.156461. Online ahead of print.ABSTRACTEstablishing a balance between Th1 and Th2 subsets and M1- and M2-type macrophages is essential for the control of Leishmania infection. The suppressors of cytokine secretion (SOCS) proteins, particularly SOCS1 and SOCS3, play a significant role in regulating cytokine-triggered signaling pathways, thereby impacting the macrophage-and effector T-cell mediated antileishmanial immune response. In addition to the pro-inflammatory cytokines, Leishmania-derived lipophosphoglycan (LPG) and CpG-DNA interact with TLR2 and TLR9 to trigger...
Source: Cytokine - December 8, 2023 Category: Molecular Biology Authors: Abdollah Jafarzadeh Dhiraj Gurjar Neelam Bodhale Sara Jafarzadeh Maryam Nemati Iraj Sharifi Bhaskar Saha Source Type: research
Aberrant expression of SOCS impairs the anti-leishmanial immune response
Cytokine. 2023 Dec 7;174:156461. doi: 10.1016/j.cyto.2023.156461. Online ahead of print.ABSTRACTEstablishing a balance between Th1 and Th2 subsets and M1- and M2-type macrophages is essential for the control of Leishmania infection. The suppressors of cytokine secretion (SOCS) proteins, particularly SOCS1 and SOCS3, play a significant role in regulating cytokine-triggered signaling pathways, thereby impacting the macrophage-and effector T-cell mediated antileishmanial immune response. In addition to the pro-inflammatory cytokines, Leishmania-derived lipophosphoglycan (LPG) and CpG-DNA interact with TLR2 and TLR9 to trigger...
Source: Cytokine - December 8, 2023 Category: Molecular Biology Authors: Abdollah Jafarzadeh Dhiraj Gurjar Neelam Bodhale Sara Jafarzadeh Maryam Nemati Iraj Sharifi Bhaskar Saha Source Type: research
Lipopolysaccharide inhibits translation of iron chaperone PCBP1 to regulate inflammatory cytokine response in macrophage
Cytokine. 2023 Dec 6;174:156456. doi: 10.1016/j.cyto.2023.156456. Online ahead of print.ABSTRACTMacrophages play a key role in maintaining systemic iron homeostasis and immunity. During pro-inflammatory stage macrophages retain iron due to the decrease of the unique iron exporter ferroportin. Increased cellular iron is sequestered in to storage protein ferritin by iron chaperone poly(rC)-binding protein 1 (PCBP1). However, the fate of PCBP1 and its interaction with ferritin in pro-inflammatory macrophages has not been studied so far. Here we report that PCBP1 protein level is down-regulated in lipopolysaccharide (LPS) trea...
Source: Cytokine - December 7, 2023 Category: Molecular Biology Authors: Sameeksha Yadav Neeraj K Saini Diksha Kulshreshtha Chinmay K Mukhopadhyay Source Type: research
Lipopolysaccharide inhibits translation of iron chaperone PCBP1 to regulate inflammatory cytokine response in macrophage
Cytokine. 2023 Dec 6;174:156456. doi: 10.1016/j.cyto.2023.156456. Online ahead of print.ABSTRACTMacrophages play a key role in maintaining systemic iron homeostasis and immunity. During pro-inflammatory stage macrophages retain iron due to the decrease of the unique iron exporter ferroportin. Increased cellular iron is sequestered in to storage protein ferritin by iron chaperone poly(rC)-binding protein 1 (PCBP1). However, the fate of PCBP1 and its interaction with ferritin in pro-inflammatory macrophages has not been studied so far. Here we report that PCBP1 protein level is down-regulated in lipopolysaccharide (LPS) trea...
Source: Cytokine - December 7, 2023 Category: Molecular Biology Authors: Sameeksha Yadav Neeraj K Saini Diksha Kulshreshtha Chinmay K Mukhopadhyay Source Type: research
Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis
Cytokine. 2023 Dec 5;174:156457. doi: 10.1016/j.cyto.2023.156457. Online ahead of print.ABSTRACTThe level of IL-2 increases markedly in serum and central nervous system (CNS) of patients with multiple sclerosis (MS) and animals with experimental allergic encephalomyelitis (EAE). However, mechanisms by which IL-2 is induced under autoimmune demyelinating conditions are poorly understood. The present study underlines the importance of IL-12p40 homodimer (p402), the so-called biologically inactive molecule, in inducing the expression of IL-2 in mouse BV-2 microglial cells, primary mouse and human microglia, mouse peritoneal m...
Source: Cytokine - December 6, 2023 Category: Molecular Biology Authors: Malabendu Jana Susanta Mondal Arundhati Jana Kalipada Pahan Source Type: research
Impact of IL-6 rs1800795 and IL-17A rs2275913 gene polymorphisms on the COVID-19 prognosis and susceptibility in a sample of Iranian patients
CONCLUSION: The rs1800795 GG genotype and G allele were associated with disease severity, and INR, D-dimer, respiratory rate, IL-6 serum concentration, and IL-6 rs1800795 GG genotype were predictive of COVID-19 mortality.PMID:38056249 | DOI:10.1016/j.cyto.2023.156445 (Source: Cytokine)
Source: Cytokine - December 6, 2023 Category: Molecular Biology Authors: Mostafa Khafaei Reza Asghari Fariba Zafari Morteza Sadeghi Source Type: research
CXCL6 promotes the progression of NAFLD through regulation of PPAR α
Cytokine. 2023 Dec 5;174:156459. doi: 10.1016/j.cyto.2023.156459. Online ahead of print.ABSTRACTAn increasing number of studies have shown that Nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity, insulin resistance, dyslipidemia, hypertension and metabolic syndrome, but its specific pathogenesis remains unclear. By analyzing GEO database, we found CXCL6 was upregulated in liver tissues of patients with NAFLD. We also confirmed with qPCR that CXCL6 is highly expressed in serum of patients with NAFLD. To identify the underlying impact of CXCL6 on NAFLD, we established animal and cell models of NAFLD...
Source: Cytokine - December 6, 2023 Category: Molecular Biology Authors: Yanli Zou Ting Zhan Jiaxi Liu Jie Tan Weijie Liu Shasha Huang Yisan Cai Ming Huang Xiaodong Huang Xia Tian Source Type: research
