Th17/IL-17A axis is critical for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc): SSc patients with high levels of serum IL-17A exhibit reduced lung functions and increased prevalence of PAH

CONCLUSION: We found that SSc patients with high levels of serum IL-17A or both IL-17A and IL-6 show reduced lung functions and high prevalence of PAH. Consequently, it is highly probable that Th17/IL-17A axis is critical for the prevalence of PAH in SSc patients.PMID:38354516 | DOI:10.1016/j.cyto.2024.156534

Source: Cytokine - February 14, 2024 Category: Molecular Biology Authors: Noriyasu Seki Hideto Tsujimoto Shuhei Tanemura Sho Ishigaki Hiroshi Takei Kunio Sugahara Keiko Yoshimoto Mitsuhiro Akiyama Yuko Kaneko Kenji Chiba Tsutomu Takeuchi Source Type: research