Cellular and Molecular Neurobiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The Impact of Cerebral Ischemia on Antioxidant Enzymes Activity and Neuronal Damage in the Hippocampus
This study explores hippocampal neuronal damage and enzymatic antioxidant activity during ischemia and reperfusion's early and late stages.PMID:37740074 | DOI:10.1007/s10571-023-01413-w (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Jafar Sadeghzadeh Leila Hosseini Ahmad Mobed Hamid Soltani Zangbar Jaber Jafarzadeh Jamshid Pasban Parviz Shahabi Source Type: research
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Cell Mol Neurobiol. 2023 Sep 22. doi: 10.1007/s10571-023-01405-w. Online ahead of print.ABSTRACTTo study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard database: 1. Perception of sound (PoS), 2. Acoustic stimulation (AcouStim), and 3. Tinnitus (Tin). Enrichment analysis by the DAVID database resulted in similar Gene Ontology (GO) terms for cellular components in all gene lists, reflecting synaptic structures known to be involved in auditory processing. The STRING protein-protein interaction (PPI) network and the Cytoscape data an...
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Johann Gross Marlies Knipper Birgit Mazurek Source Type: research
The Impact of Cerebral Ischemia on Antioxidant Enzymes Activity and Neuronal Damage in the Hippocampus
This study explores hippocampal neuronal damage and enzymatic antioxidant activity during ischemia and reperfusion's early and late stages.PMID:37740074 | DOI:10.1007/s10571-023-01413-w (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Jafar Sadeghzadeh Leila Hosseini Ahmad Mobed Hamid Soltani Zangbar Jaber Jafarzadeh Jamshid Pasban Parviz Shahabi Source Type: research
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Cell Mol Neurobiol. 2023 Sep 22. doi: 10.1007/s10571-023-01405-w. Online ahead of print.ABSTRACTTo study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard database: 1. Perception of sound (PoS), 2. Acoustic stimulation (AcouStim), and 3. Tinnitus (Tin). Enrichment analysis by the DAVID database resulted in similar Gene Ontology (GO) terms for cellular components in all gene lists, reflecting synaptic structures known to be involved in auditory processing. The STRING protein-protein interaction (PPI) network and the Cytoscape data an...
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Johann Gross Marlies Knipper Birgit Mazurek Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development
Cell Mol Neurobiol. 2023 Sep 19. doi: 10.1007/s10571-023-01408-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. AD is also associated with other pathologies such as neuroinflammation, dysfunction of synaptic connections and circuits, disorders in mitochondrial function and energy production, epigenetic changes, and abnormalities in the vascular system. Despite extensive research con...
Source: Cellular and Molecular Neurobiology - September 19, 2023 Category: Cytology Authors: Bhavarth P Dave Yesha B Shah Kunal G Maheshwari Kaif A Mansuri Bhadrawati S Prajapati Humzah I Postwala Mehul R Chorawala Source Type: research
Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development
Cell Mol Neurobiol. 2023 Sep 19. doi: 10.1007/s10571-023-01408-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. AD is also associated with other pathologies such as neuroinflammation, dysfunction of synaptic connections and circuits, disorders in mitochondrial function and energy production, epigenetic changes, and abnormalities in the vascular system. Despite extensive research con...
Source: Cellular and Molecular Neurobiology - September 19, 2023 Category: Cytology Authors: Bhavarth P Dave Yesha B Shah Kunal G Maheshwari Kaif A Mansuri Bhadrawati S Prajapati Humzah I Postwala Mehul R Chorawala Source Type: research
Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia
Cell Mol Neurobiol. 2023 Sep 16. doi: 10.1007/s10571-023-01407-8. Online ahead of print.ABSTRACTIsolated exposure to intermittent hypoxia and permissive hypercapnia activates signaling mechanisms that induce ultrastructural changes in mitochondria and endoplasmic reticulum, accompanied by the development of maximal ischemic tolerance in neurons under the combined influence of these factors. However, there are a lack of data on the combined impact of these factors on the ultrastructure of neuronal organelles. The present study aims to comparatively assess the ultrastructural changes in neurons following isolated and combine...
Source: Cellular and Molecular Neurobiology - September 16, 2023 Category: Cytology Authors: Pavel Tregub Yuri Motin Vladimir Kulikov Pavel Kovzelev Aleksandra Chaykovskaya Irada Ibrahimli Source Type: research
Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia
Cell Mol Neurobiol. 2023 Sep 16. doi: 10.1007/s10571-023-01407-8. Online ahead of print.ABSTRACTIsolated exposure to intermittent hypoxia and permissive hypercapnia activates signaling mechanisms that induce ultrastructural changes in mitochondria and endoplasmic reticulum, accompanied by the development of maximal ischemic tolerance in neurons under the combined influence of these factors. However, there are a lack of data on the combined impact of these factors on the ultrastructure of neuronal organelles. The present study aims to comparatively assess the ultrastructural changes in neurons following isolated and combine...
Source: Cellular and Molecular Neurobiology - September 16, 2023 Category: Cytology Authors: Pavel Tregub Yuri Motin Vladimir Kulikov Pavel Kovzelev Aleksandra Chaykovskaya Irada Ibrahimli Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
A Perfused In Vitro Human iPSC-Derived Blood-Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
Cell Mol Neurobiol. 2023 Sep 12. doi: 10.1007/s10571-023-01404-x. Online ahead of print.ABSTRACTDelivering biologics to elicit a therapeutic response in the central nervous system (CNS) remains challenging due to the presence of the blood-brain barrier (BBB). Receptor-mediated transcytosis is a strategy to improve brain exposure after systemic drug administration. The availability of a clinically relevant in vitro BBB model is crucial to investigate transcytosis pathways and to predict the penetration of biologics into the CNS. We created a perfused human in vitro BBB model made of induced pluripotent stem cells (iPSC)-der...
Source: Cellular and Molecular Neurobiology - September 12, 2023 Category: Cytology Authors: Floriana Burgio Carine Gaiser Kevin Brady Viviana Gatta Reiner Class Ramona Schrage Laura Suter-Dick Source Type: research
