Cellular and Molecular Neurobiology 
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Cell Mol Neurobiol. 2023 Nov;43(8):4071-4101. doi: 10.1007/s10571-023-01432-7. Epub 2023 Nov 13.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associ...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Cell Mol Neurobiol. 2023 Nov;43(8):4071-4101. doi: 10.1007/s10571-023-01432-7. Epub 2023 Nov 13.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associ...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Cell Mol Neurobiol. 2023 Nov 13. doi: 10.1007/s10571-023-01432-7. Online ahead of print.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associated wit...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Cell Mol Neurobiol. 2023 Nov 13. doi: 10.1007/s10571-023-01432-7. Online ahead of print.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associated wit...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Cell Mol Neurobiol. 2023 Nov 13. doi: 10.1007/s10571-023-01432-7. Online ahead of print.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associated wit...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Cell Mol Neurobiol. 2023 Nov 13. doi: 10.1007/s10571-023-01432-7. Online ahead of print.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associated wit...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Cell Mol Neurobiol. 2023 Nov 13. doi: 10.1007/s10571-023-01432-7. Online ahead of print.ABSTRACTMECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associated wit...
Source: Cellular and Molecular Neurobiology - November 13, 2023 Category: Cytology Authors: Arshad Mehmood Suleman Shah Ruo-Yi Guo Arsalan Haider Mengya Shi Hamid Ali Ijaz Ali Riaz Ullah Bin Li Source Type: research
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Cell Mol Neurobiol. 2023 Nov 7. doi: 10.1007/s10571-023-01430-9. Online ahead of print.ABSTRACTNeuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating magnetic fields (2 kHz and 83.3 MHz), has been shown to have high efficacy for fibromyalgia and low back pain in our previous clinical trials. The aim of this study was to elucidate the underlying analgesic mechanism of the AT-04 using the partial sciatic nerve ligation (PSL) model as an animal model of neuropathic pain. AT-04 was applied to PSL model rats with hyperalgesia and its pain-improving effect was verifie...
Source: Cellular and Molecular Neurobiology - November 7, 2023 Category: Cytology Authors: Tatsuro Kohno Kaori Takaki Kaori Kishita Kazunori Mitsutake Nozomu Tofuku Iwao Kishita Source Type: research
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Cell Mol Neurobiol. 2023 Nov 7. doi: 10.1007/s10571-023-01430-9. Online ahead of print.ABSTRACTNeuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating magnetic fields (2 kHz and 83.3 MHz), has been shown to have high efficacy for fibromyalgia and low back pain in our previous clinical trials. The aim of this study was to elucidate the underlying analgesic mechanism of the AT-04 using the partial sciatic nerve ligation (PSL) model as an animal model of neuropathic pain. AT-04 was applied to PSL model rats with hyperalgesia and its pain-improving effect was verifie...
Source: Cellular and Molecular Neurobiology - November 7, 2023 Category: Cytology Authors: Tatsuro Kohno Kaori Takaki Kaori Kishita Kazunori Mitsutake Nozomu Tofuku Iwao Kishita Source Type: research
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Cell Mol Neurobiol. 2023 Nov 7. doi: 10.1007/s10571-023-01430-9. Online ahead of print.ABSTRACTNeuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating magnetic fields (2 kHz and 83.3 MHz), has been shown to have high efficacy for fibromyalgia and low back pain in our previous clinical trials. The aim of this study was to elucidate the underlying analgesic mechanism of the AT-04 using the partial sciatic nerve ligation (PSL) model as an animal model of neuropathic pain. AT-04 was applied to PSL model rats with hyperalgesia and its pain-improving effect was verifie...
Source: Cellular and Molecular Neurobiology - November 7, 2023 Category: Cytology Authors: Tatsuro Kohno Kaori Takaki Kaori Kishita Kazunori Mitsutake Nozomu Tofuku Iwao Kishita Source Type: research
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Cell Mol Neurobiol. 2023 Nov 7. doi: 10.1007/s10571-023-01430-9. Online ahead of print.ABSTRACTNeuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating magnetic fields (2 kHz and 83.3 MHz), has been shown to have high efficacy for fibromyalgia and low back pain in our previous clinical trials. The aim of this study was to elucidate the underlying analgesic mechanism of the AT-04 using the partial sciatic nerve ligation (PSL) model as an animal model of neuropathic pain. AT-04 was applied to PSL model rats with hyperalgesia and its pain-improving effect was verifie...
Source: Cellular and Molecular Neurobiology - November 7, 2023 Category: Cytology Authors: Tatsuro Kohno Kaori Takaki Kaori Kishita Kazunori Mitsutake Nozomu Tofuku Iwao Kishita Source Type: research
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Cell Mol Neurobiol. 2023 Nov 7. doi: 10.1007/s10571-023-01430-9. Online ahead of print.ABSTRACTNeuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating magnetic fields (2 kHz and 83.3 MHz), has been shown to have high efficacy for fibromyalgia and low back pain in our previous clinical trials. The aim of this study was to elucidate the underlying analgesic mechanism of the AT-04 using the partial sciatic nerve ligation (PSL) model as an animal model of neuropathic pain. AT-04 was applied to PSL model rats with hyperalgesia and its pain-improving effect was verifie...
Source: Cellular and Molecular Neurobiology - November 7, 2023 Category: Cytology Authors: Tatsuro Kohno Kaori Takaki Kaori Kishita Kazunori Mitsutake Nozomu Tofuku Iwao Kishita Source Type: research
Genetic Features of Young and Aged Animals After Peripheral Nerve Injury: Implications for Diminished Regeneration Capacity
Cell Mol Neurobiol. 2023 Nov 3. doi: 10.1007/s10571-023-01431-8. Online ahead of print.ABSTRACTThe spontaneous regeneration capacity of peripheral nerves is fundamentally reduced with advancing age, leading to severe and long-term functional loss. The cellular and molecular basis underlying incomplete and delayed recovery of aging peripheral nerves is still murky. Here, we collected sciatic nerves of aged rats at 1d, 4d, and 7d after nerve injury, systematically analyzed the transcriptional changes of injured sciatic nerves, and examined the differences of injury responses between aged rats and young rats. RNA sequencing r...
Source: Cellular and Molecular Neurobiology - November 3, 2023 Category: Cytology Authors: Weixiao Huang Sheng Yi Lili Zhao Source Type: research
Genetic Features of Young and Aged Animals After Peripheral Nerve Injury: Implications for Diminished Regeneration Capacity
Cell Mol Neurobiol. 2023 Nov 3. doi: 10.1007/s10571-023-01431-8. Online ahead of print.ABSTRACTThe spontaneous regeneration capacity of peripheral nerves is fundamentally reduced with advancing age, leading to severe and long-term functional loss. The cellular and molecular basis underlying incomplete and delayed recovery of aging peripheral nerves is still murky. Here, we collected sciatic nerves of aged rats at 1d, 4d, and 7d after nerve injury, systematically analyzed the transcriptional changes of injured sciatic nerves, and examined the differences of injury responses between aged rats and young rats. RNA sequencing r...
Source: Cellular and Molecular Neurobiology - November 3, 2023 Category: Cytology Authors: Weixiao Huang Sheng Yi Lili Zhao Source Type: research
Genetic Features of Young and Aged Animals After Peripheral Nerve Injury: Implications for Diminished Regeneration Capacity
Cell Mol Neurobiol. 2023 Nov 3. doi: 10.1007/s10571-023-01431-8. Online ahead of print.ABSTRACTThe spontaneous regeneration capacity of peripheral nerves is fundamentally reduced with advancing age, leading to severe and long-term functional loss. The cellular and molecular basis underlying incomplete and delayed recovery of aging peripheral nerves is still murky. Here, we collected sciatic nerves of aged rats at 1d, 4d, and 7d after nerve injury, systematically analyzed the transcriptional changes of injured sciatic nerves, and examined the differences of injury responses between aged rats and young rats. RNA sequencing r...
Source: Cellular and Molecular Neurobiology - November 3, 2023 Category: Cytology Authors: Weixiao Huang Sheng Yi Lili Zhao Source Type: research
