Cellular and Molecular Neurobiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period
In conclusion, we found that the second, third and fourth weeks after birth were important periods of VIP-AC development. Many developmental changes occurred around eye opening. The development of soma, dendrite and electrophysiological properties showed uneven dynamics of progression. Cell differentiation may contribute to soma development whereas the changes of different ion channels may play important role for spine development.PMID:38315298 | PMC:PMC10844409 | DOI:10.1007/s10571-024-01452-x (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - February 5, 2024 Category: Cytology Authors: Xuhong Zhang Xiaoyu Wang Yanqing Li Yingying Zhang Hong Zhu Chen Xie Yudong Zhou Ye Shen Jianping Tong Source Type: research
Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Cell Mol Neurobiol. 2024 Feb 5;44(1):18. doi: 10.1007/s10571-023-01451-4.ABSTRACTMultiple studies have shown that clinical events resulting into neonatal IL-4 over-exposure, such as asthma in early life and food allergy, were associated with brain damage and that the neuroinflammation induced by them might lead to cognitive impairments, anxiety-/depressive-like behaviors. IL-4 is the most major elevated cytokine in periphery when these clinical events occur and peripheral IL-4 level positively correlates with the severity of those events. Our previous studies have verified that neonatal IL-4 over-exposure induced a delayed...
Source: Cellular and Molecular Neurobiology - February 5, 2024 Category: Cytology Authors: Ling Wang Haoran Sha Xiaoyi He Yinyin Xie Jiapeng Deng Jiexuan Chen Guoying Li Junhua Yang Source Type: research
Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling
Cell Mol Neurobiol. 2024 Jan 29;44(1):17. doi: 10.1007/s10571-023-01439-0.ABSTRACTExercise can promote adult neurogenesis and improve symptoms associated with schizophrenia and other mental disorders via parvalbumin (PV)-positive GABAergic interneurons in the dentate gyrus ErbB4 is the receptor of neurotrophic factor neuregulin 1, expressed mostly in PV-positive interneurons. Whether ErbB4 in PV-positive neurons mediates the beneficial effect of exercise and adult neurogenesis on mental disorder needs to be further investigation. Here, we first conducted a four-week study on the effects of AG1478, an ErbB4 inhibitor, on me...
Source: Cellular and Molecular Neurobiology - January 29, 2024 Category: Cytology Authors: Yandong Yi Yuejin Zhang Yuanlong Song Yisheng Lu Source Type: research
CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
The objective of this study was to investigate the association of circSKA3 with the risk of extracranial artery stenosis (ECAS) and plaque instability in patients with ischemic stroke. We constructed a competing endogenous RNA (ceRNA) network regulated by circSKA3 based on differentially expressed circRNAs and mRNAs between five patients and five controls. Gene Ontology (GO) analysis was performed on the 65 mRNAs within the network, revealing their primary involvement in inflammatory biological processes. A total of 284 ischemic stroke patients who underwent various imaging examinations were included for further analyses. ...
Source: Cellular and Molecular Neurobiology - January 10, 2024 Category: Cytology Authors: Ning Zhu Ziyi Wang Mingfeng Tao Yongxin Li Lihua Shen Tian Xu Source Type: research
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
This study extracted IS-related transcriptome datasets from the Gene Expression Omnibus (GEO) database. The target genes were obtained by intersecting the differentially expressed genes (DEGs), the module genes related to IS, and PRGs, where the key genes of IS were screened by two machine learning algorithms. The key genes-based diagnostic model was constructed. Gene set enrichment analysis (GSEA) and the immune microenvironment analyses were analyzed targeting key genes in IS. The co-expression, TF-mRNA, and competitive endogenous RNAs (ceRNA) regulatory networks were constructed to reveal the potential regulation of key...
Source: Cellular and Molecular Neurobiology - January 4, 2024 Category: Cytology Authors: Yuan Li Yuanlu Shu Kun Yu Ruihan Ni Lan Chu Source Type: research
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
This study extracted IS-related transcriptome datasets from the Gene Expression Omnibus (GEO) database. The target genes were obtained by intersecting the differentially expressed genes (DEGs), the module genes related to IS, and PRGs, where the key genes of IS were screened by two machine learning algorithms. The key genes-based diagnostic model was constructed. Gene set enrichment analysis (GSEA) and the immune microenvironment analyses were analyzed targeting key genes in IS. The co-expression, TF-mRNA, and competitive endogenous RNAs (ceRNA) regulatory networks were constructed to reveal the potential regulation of key...
Source: Cellular and Molecular Neurobiology - January 4, 2024 Category: Cytology Authors: Yuan Li Yuanlu Shu Kun Yu Ruihan Ni Lan Chu Source Type: research
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
This study extracted IS-related transcriptome datasets from the Gene Expression Omnibus (GEO) database. The target genes were obtained by intersecting the differentially expressed genes (DEGs), the module genes related to IS, and PRGs, where the key genes of IS were screened by two machine learning algorithms. The key genes-based diagnostic model was constructed. Gene set enrichment analysis (GSEA) and the immune microenvironment analyses were analyzed targeting key genes in IS. The co-expression, TF-mRNA, and competitive endogenous RNAs (ceRNA) regulatory networks were constructed to reveal the potential regulation of key...
Source: Cellular and Molecular Neurobiology - January 4, 2024 Category: Cytology Authors: Yuan Li Yuanlu Shu Kun Yu Ruihan Ni Lan Chu Source Type: research
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
This study extracted IS-related transcriptome datasets from the Gene Expression Omnibus (GEO) database. The target genes were obtained by intersecting the differentially expressed genes (DEGs), the module genes related to IS, and PRGs, where the key genes of IS were screened by two machine learning algorithms. The key genes-based diagnostic model was constructed. Gene set enrichment analysis (GSEA) and the immune microenvironment analyses were analyzed targeting key genes in IS. The co-expression, TF-mRNA, and competitive endogenous RNAs (ceRNA) regulatory networks were constructed to reveal the potential regulation of key...
Source: Cellular and Molecular Neurobiology - January 4, 2024 Category: Cytology Authors: Yuan Li Yuanlu Shu Kun Yu Ruihan Ni Lan Chu Source Type: research
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
This study extracted IS-related transcriptome datasets from the Gene Expression Omnibus (GEO) database. The target genes were obtained by intersecting the differentially expressed genes (DEGs), the module genes related to IS, and PRGs, where the key genes of IS were screened by two machine learning algorithms. The key genes-based diagnostic model was constructed. Gene set enrichment analysis (GSEA) and the immune microenvironment analyses were analyzed targeting key genes in IS. The co-expression, TF-mRNA, and competitive endogenous RNAs (ceRNA) regulatory networks were constructed to reveal the potential regulation of key...
Source: Cellular and Molecular Neurobiology - January 4, 2024 Category: Cytology Authors: Yuan Li Yuanlu Shu Kun Yu Ruihan Ni Lan Chu Source Type: research
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
This study extracted IS-related transcriptome datasets from the Gene Expression Omnibus (GEO) database. The target genes were obtained by intersecting the differentially expressed genes (DEGs), the module genes related to IS, and PRGs, where the key genes of IS were screened by two machine learning algorithms. The key genes-based diagnostic model was constructed. Gene set enrichment analysis (GSEA) and the immune microenvironment analyses were analyzed targeting key genes in IS. The co-expression, TF-mRNA, and competitive endogenous RNAs (ceRNA) regulatory networks were constructed to reveal the potential regulation of key...
Source: Cellular and Molecular Neurobiology - January 4, 2024 Category: Cytology Authors: Yuan Li Yuanlu Shu Kun Yu Ruihan Ni Lan Chu Source Type: research
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
This article reviews the basic anatomy and physiology of the glymphatic system. Imaging techniques to visualize the function of the glymphatic system mainly including post-contrast imaging techniques, indirect lymphatic assessment by detecting increased perivascular space, and diffusion tensor image analysis along the perivascular space (DTI-ALPS) are discussed. The pathological link between glymphatic system dysfunction and neurological disorders is the key point, focusing on the enlarged perivascular space (EPVS) and the index of diffusivity along the perivascular space (ALPS index), which may represent the activity of t...
Source: Cellular and Molecular Neurobiology - December 29, 2023 Category: Cytology Authors: Jun Zhang Shengwen Liu Yaqi Wu Zhijian Tang Yasong Wu Yiwei Qi Fangyong Dong Yu Wang Source Type: research
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
This article reviews the basic anatomy and physiology of the glymphatic system. Imaging techniques to visualize the function of the glymphatic system mainly including post-contrast imaging techniques, indirect lymphatic assessment by detecting increased perivascular space, and diffusion tensor image analysis along the perivascular space (DTI-ALPS) are discussed. The pathological link between glymphatic system dysfunction and neurological disorders is the key point, focusing on the enlarged perivascular space (EPVS) and the index of diffusivity along the perivascular space (ALPS index), which may represent the activity of t...
Source: Cellular and Molecular Neurobiology - December 29, 2023 Category: Cytology Authors: Jun Zhang Shengwen Liu Yaqi Wu Zhijian Tang Yasong Wu Yiwei Qi Fangyong Dong Yu Wang Source Type: research
Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network
In this study, we aimed to identify a gene expression signature using an artificial neural network (ANN) in application to microarray and serial analysis of gene expression (SAGE) data for grade 3 (AG) and grade 4 (GBM) gliomas discrimination. We acquired gene expression data from publicly available datasets on glial tumors of grades 3 and 4-a total of 93 grade 3 gliomas and 224 grade 4 gliomas. To select genes for classification, we implemented an artificial neural network-based method using a combination of self-organized maps (SOM) and perceptron. In general, we implemented a multi-stage procedure that involved multiple...
Source: Cellular and Molecular Neurobiology - December 27, 2023 Category: Cytology Authors: Aleksei A Mekler Dmitry R Schwartz Olga E Savelieva Source Type: research
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology
Cell Mol Neurobiol. 2023 Dec 27;44(1):12. doi: 10.1007/s10571-023-01447-0.ABSTRACTIntracranial vascular malformations manifest on a continuum ranging from predominantly arterial to predominantly venous in pathology. Cerebral cavernous malformations (CCMs) are capillary malformations that exist at the midpoint of this continuum. The axon guidance factor Ephrin B2 and its receptor EphB4 are critical regulators of vasculogenesis in the developing central nervous system. Ephrin B2/EphB4 dysregulation has been implicated in the pathogenesis of arterial-derived arteriovenous malformations and vein-based vein of Galen malformatio...
Source: Cellular and Molecular Neurobiology - December 27, 2023 Category: Cytology Authors: Julie Sesen Aram Ghalali Jessica Driscoll Tyra Martinez Adrien Lupieri David Zurakowski Sanda Alexandrescu Edward R Smith Katie P Fehnel Source Type: research
Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
Cell Mol Neurobiol. 2023 Dec 27;44(1):11. doi: 10.1007/s10571-023-01442-5.ABSTRACTThe adult peripheral nervous system has a significant ability for regeneration compared to the central nervous system. This is related to the unique neuroimmunomodulation after peripheral nerve injury (PNI). Unlike the repair of other tissues after injury, Schwann cells (SCs) respond immediately to the trauma and send out signals to precisely recruit macrophages to the injured site. Then, macrophages promote the degradation of the damaged myelin sheath by phagocytosis of local debris. At the same time, macrophages and SCs jointly secrete vari...
Source: Cellular and Molecular Neurobiology - December 27, 2023 Category: Cytology Authors: Guanggeng Wu Xiaoyue Wen Rui Kuang KoonHei Winson Lui Bo He Ge Li Zhaowei Zhu Source Type: research
