Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis
Cell Mol Neurobiol. 2023 Oct 13. doi: 10.1007/s10571-023-01419-4. Online ahead of print.ABSTRACTParkinson's disease (PD) is caused due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) which leads to the depletion of dopamine in the body. The lack of dopamine is mainly due to aggregation of misfolded α-synuclein which causes motor impairment in PD. Dopamine is also required for normal retinal function and the light-dark vision cycle. Misfolded α-synuclein present in inner retinal layers causes vision-associated problems in PD patients. Hence, individuals with PD also experience structur...
Source: Cellular and Molecular Neurobiology - October 13, 2023 Category: Cytology Authors: Mohana Devi Subramaniam P Aishwarya Janaki B Abishek Kumar Janani Gopalarethinam Aswathy P Nair I Mahalaxmi Balachandar Vellingiri Source Type: research

High Intensity Interval Training can Ameliorate Hypothalamic Appetite Regulation in Male Rats with Type 2 Diabetes: The Role of Leptin
In this study, 20 male Wister rats were randomly assigned to one of four groups: CO (non-type 2 diabetes control), T2D (type 2 diabetes), EX (non-type 2 diabetes exercise), and T2D + EX (type 2 diabetes + exercise).To induce T2D, a combination of a high-fat diet for 2 months and a single dose of streptozotocin (35 mg/kg) was administered. Rats in the EX and T2D + EX groups performed 4-10 intervals of treadmill running at 80-100% of their maximum velocity (Vmax). Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), serum levels of insulin (INS) and LEP (LEPS) as well as hypothalamic expression of LEP receptors (LE...
Source: Cellular and Molecular Neurobiology - October 12, 2023 Category: Cytology Authors: Kayvan Khoramipour Maryam Hossein Rezaei Elham Madadizadeh Mahdieh Sadat Hosseini Zahra Soltani Janis Schierbauer Othmar Moser Source Type: research

The Role of Oxidative Stress in Trisomy 21 Phenotype
Cell Mol Neurobiol. 2023 Oct 11. doi: 10.1007/s10571-023-01417-6. Online ahead of print.ABSTRACTExtensive research has been conducted to gain a deeper understanding of the deregulated metabolic pathways in the development of trisomy 21 (T21) or Down syndrome. This research has shed light on the hypothesis that oxidative stress plays a significant role in the manifestation of the T21 phenotype. Although in vivo studies have shown promising results in mitigating the detrimental effects of oxidative stress, there is currently a lack of introduced antioxidant treatment options targeting cognitive impairments associated with T2...
Source: Cellular and Molecular Neurobiology - October 11, 2023 Category: Cytology Authors: Angelika Buczy ńska Iwona Sidorkiewicz Adam Jacek Kr ętowski Monika Zbucka-Kr ętowska Source Type: research

The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway
Cell Mol Neurobiol. 2023 Oct 9. doi: 10.1007/s10571-023-01416-7. Online ahead of print.ABSTRACTVascular dementia (VD) is characterized with vascular cognitive impairment (VCI), which currently has few effective therapies in clinic. Neuronal damage and white matter injury are involved in the pathogenesis of VCI. Citicoline has been demonstrated to exhibit neuroprotection and neurorepair to improve cognition in cerebrovascular diseases. Nicotinamide adenine dinucleotide (NAD+)-dependent sirtuin (SIRT) signaling pathway constitutes a strong intrinsic defense system against various stresses including neuroinflammation in VCI. ...
Source: Cellular and Molecular Neurobiology - October 9, 2023 Category: Cytology Authors: Ning Zhao Xiaofeng Zhu Luyang Xie Xin Guan Leilei Tang Guojun Jiang Tao Pang Source Type: research

Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia
Cell Mol Neurobiol. 2023 Oct 6. doi: 10.1007/s10571-023-01415-8. Online ahead of print.ABSTRACTHypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the context of energy metabolism, is controlled by extracellular concentration of purines, regulated by ecto-enzymes, such as e-NTPDase-1/CD39, ecto-5'-NT/CD73, and eADA. We hypothesize that hypercholesterolemia, via modulation of the activity of nucleotide metabolism-regulating ecto-enzymes, deteriorates glycolytic efficiency and energy metabolism of endothelial cells, which may potentiall...
Source: Cellular and Molecular Neurobiology - October 6, 2023 Category: Cytology Authors: Ewelina Czuba-Paku ła Iwona Pelikant-Ma łecka Gra żyna Lietzau S ławomir Wójcik Ryszard T Smole ński Przemys ław Kowiański Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research