Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/ β-Catenin and PI3K/AKT Signaling Pathways
Cell Mol Neurobiol. 2023 Sep 25. doi: 10.1007/s10571-023-01414-9. Online ahead of print.ABSTRACTGliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most aggressive type. The clinical prognosis of GBM patients remains bleak despite the availability of multiple options for therapy, which has needed us to explore new therapeutic methods to face the rapid progression, short survival, and therapy resistance of glioblastomas. As the Human Genome Project advances, long noncoding RNAs (lncRNAs) have attracted the attention of researchers and clinicians in cancer rese...
Source: Cellular and Molecular Neurobiology - September 25, 2023 Category: Cytology Authors: Hanyun Li Jilan Liu Xianyun Qin Jikui Sun Yan Liu Feng Jin Source Type: research

The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
In this study, a selective mTOR inhibitor, everolimus, was applied to investigate the outcome after ICH and the possible underlying mechanism. The ICH model was established by autologous blood injection. Everolimus (50 and 100 µg/kg) was administered intraperitoneally for 14 consecutive days' post-operation. The neurological functions were examined at 3, 7, and 14 days' post-ICH. Samples of brain tissue were collected to perform histopathological and immunohistochemical (NF-k-positive cell) examinations. Besides, the striatum was used to evaluate parameters related to oxidative stress (superoxide dismutase (SOD) activity,...
Source: Cellular and Molecular Neurobiology - September 25, 2023 Category: Cytology Authors: Shima Shirzad Farzaneh Vafaee Fatemeh Forouzanfar Source Type: research

N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model
Cell Mol Neurobiol. 2023 Sep 24. doi: 10.1007/s10571-023-01410-z. Online ahead of print.ABSTRACTStatus epilepticus (SE) is described as continuous and self-sustaining seizures, which triggers hippocampal neurodegeneration, inflammation, and gliosis. N-formyl peptide receptor (FPR) has been associated with inflammatory process. N-formyl-methionyl-leucyl-phenylalanine (fMLP) peptide plays an anti-inflammatory role, mediated by the activation of G-protein-coupled FPR. Here, we evaluated the influence of fMLP peptides on the behavior of limbic seizures, memory consolidation, and hippocampal neurodegeneration process. Male Wist...
Source: Cellular and Molecular Neurobiology - September 24, 2023 Category: Cytology Authors: Igor Santana de Melo Robinson Sabino-Silva Maisa Ara újo Costa Em ília Rezende Vaz Cassius Iury Anselmo-E-Silva Thain á de Paula Soares Mendonça Kellysson Bruno Oliveira Fernanda Maria Ara újo de Souza Yngrid Mickaelli Oliveira Dos Santos Amanda Lari Source Type: research

Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Cell Mol Neurobiol. 2023 Sep 22. doi: 10.1007/s10571-023-01405-w. Online ahead of print.ABSTRACTTo study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard database: 1. Perception of sound (PoS), 2. Acoustic stimulation (AcouStim), and 3. Tinnitus (Tin). Enrichment analysis by the DAVID database resulted in similar Gene Ontology (GO) terms for cellular components in all gene lists, reflecting synaptic structures known to be involved in auditory processing. The STRING protein-protein interaction (PPI) network and the Cytoscape data an...
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Johann Gross Marlies Knipper Birgit Mazurek Source Type: research

The Impact of Cerebral Ischemia on Antioxidant Enzymes Activity and Neuronal Damage in the Hippocampus
This study explores hippocampal neuronal damage and enzymatic antioxidant activity during ischemia and reperfusion's early and late stages.PMID:37740074 | DOI:10.1007/s10571-023-01413-w (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Jafar Sadeghzadeh Leila Hosseini Ahmad Mobed Hamid Soltani Zangbar Jaber Jafarzadeh Jamshid Pasban Parviz Shahabi Source Type: research

Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research