Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections
Cell Mol Neurobiol. 2023 Sep 4. doi: 10.1007/s10571-023-01402-z. Online ahead of print.ABSTRACTInflammatory biomarkers have been very useful in detecting and monitoring inflammatory processes along with providing helpful information to select appropriate therapeutic strategies. C-reactive protein (CRP) is a nonspecific, but quite useful medical acute inflammatory biomarker and is associated with persistent chronic inflammatory processes. Several studies suggest that different levels of CRP are correlated with neurological disorders such as Alzheimer's disease (AD). However, dynamics of CRP levels have also been observed in...
Source: Cellular and Molecular Neurobiology - September 4, 2023 Category: Cytology Authors: Nitesh Kumar Poddar Arshma Khan Falak Fatima Anshulika Saxena Garima Ghaley Shahanavaj Khan Source Type: research

Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study
In conclusion, we report that the physiological clearance of ISF and beads mainly passes through the cleft between the CC/EC and striatum into the LV, or alternatively through the cortex into the subarachnoid space. Stroke delays the main route but enhances the minor route, and microglia/macrophages engulf the beads in the infarction. Ischemic stroke impairs the clearance of brain interstitial fluid/beads. Under physiological conditions, the main route ( ① ) of interstitial fluid clearance is to the lateral ventricle, and the minor one ( ② ) is to the subarachnoid space. Ischemic stroke weakens the main route ( ① ), ...
Source: Cellular and Molecular Neurobiology - August 27, 2023 Category: Cytology Authors: Tuo Yang Yang Sun Qianqian Li Nour Alraqmany Feng Zhang Source Type: research

Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway
In conclusion, the Wnt signaling pathway might be the critical mechanism in realizing the anti-ferroptosis effects of H2S against TBI. TBI induces ferroptosis-related changes characterized by iron overload, impaired antioxidant system, and lipid peroxidation at the chronic phase after TBI. However, NaHS subchronic treatment reduces the susceptibility to TBI-induced ferroptosis, at least partly by activating the Wnt signaling pathway.PMID:37624470 | DOI:10.1007/s10571-023-01399-5 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - August 25, 2023 Category: Cytology Authors: Jie Chen Zhennan Chen Dongyu Yu Yufei Yan Xiuli Hao Mingxia Zhang Tong Zhu Source Type: research

Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus
Cell Mol Neurobiol. 2023 Aug 24. doi: 10.1007/s10571-023-01398-6. Online ahead of print.ABSTRACTHeterozygous mutations affecting FOXJ1, a transcription factor governing multiciliated cell development, have been associated with obstructive hydrocephalus in humans. However, factors that disrupt multiciliated ependymal cell function often cause communicating hydrocephalus, raising questions about whether FOXJ1 mutations cause hydrocephalus primarily by blocking cerebrospinal fluid (CSF) flow or by different mechanisms. Here, we show that heterozygous FOXJ1 mutations are also associated with communicating hydrocephalus in huma...
Source: Cellular and Molecular Neurobiology - August 24, 2023 Category: Cytology Authors: Connie C Hou Danielle Li Bethany C Berry Shaokuan Zheng Rona S Carroll Mark D Johnson Hong Wei Yang Source Type: research

Biosensors, Recent Advances in Determination of BDNF and NfL
Cell Mol Neurobiol. 2023 Aug 21. doi: 10.1007/s10571-023-01401-0. Online ahead of print.ABSTRACTKey biomarkers such as Brain Derived Neurotrophic Factor (BDNF) and Neurofilament light chain (NfL) play important roles in the development and progression of many neurological diseases, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. In these clinical conditions, the underlying biomarker processes are markedly heterogeneous. In this context, robust biomarker discovery is of critical importance for screening, early detection, and monitoring of neurological diseases. The difficulty of directly identify...
Source: Cellular and Molecular Neurobiology - August 21, 2023 Category: Cytology Authors: Ahmad Mobed Saeid Charsouei Yalda Yazdani Morad Kohandel Gargari Ali Ahmadalipour Seyyedeh Reyhaneh Sadremousavi Maryam Farrahizadeh Ali Shahbazi Maryam Haghani Source Type: research