Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Cell Mol Neurobiol. 2023 Aug 10. doi: 10.1007/s10571-023-01396-8. Online ahead of print.ABSTRACTStroke is a life-threatening medical condition and is a leading cause of disability. Cerebral ischemia is characterized by a distinct inflammatory response starting with the production of various cytokines and other inflammation-related agents. Progranulin (PGRN), a multifunctional protein, is critical in diverse physiological reactions, such as cell proliferation, inflammation, wound healing, and nervous system development. A mature PGRN is anti-inflammatory, while granulin, its derivative, conversely induces pro-inflammatory c...
Source: Cellular and Molecular Neurobiology - August 10, 2023 Category: Cytology Authors: Daryush Purrahman Ali Shojaeian Łukasz A Poniatowski Bart łomiej Piechowski-Jóźwiak Mohammad-Reza Mahmoudian-Sani Source Type: research

Single-Cell RNA-Sequencing in Astrocyte Development, Heterogeneity, and Disease
Cell Mol Neurobiol. 2023 Aug 8. doi: 10.1007/s10571-023-01397-7. Online ahead of print.ABSTRACTAstrocytes are the most plentiful cell type in the central nervous system (CNS) and perform complicated functions in health and disease. It is obvious that different astrocyte subpopulations, or activation states, are relevant with specific genomic programs and functions. In recent years, the emergence of new technologies such as single-cell RNA sequencing (scRNA-seq) has made substantial advance in the characterization of astrocyte heterogeneity, astrocyte developmental trajectory, and its role in CNS diseases which has had a si...
Source: Cellular and Molecular Neurobiology - August 8, 2023 Category: Cytology Authors: Meng-Yuan Gao Jia-Qi Wang Jin He Rui Gao Yuan Zhang Xing Li Source Type: research

Sleep Disorder Kleine-Levin Syndrome (KLS) Joins the List of Polygenic Brain Disorders Associated with Obstetric Complications
Cell Mol Neurobiol. 2023 Aug 9. doi: 10.1007/s10571-023-01391-z. Online ahead of print.ABSTRACTKleine-Levin Syndrome is a rare neurological disorder with onset typically during adolescence that is characterized by recurrent episodes of hypersomnia, behavioral changes, and cognitive abnormalities, in the absence of structural changes in neuroimaging. As for many functional brain disorders, the exact disease mechanism in Kleine-Levin Syndrome is presently unknown, preventing the development of specific treatment approaches or protective measures. Here we review the pathophysiology and genetics of this functional brain disord...
Source: Cellular and Molecular Neurobiology - August 8, 2023 Category: Cytology Authors: Michael Hamper Rainald Schmidt-Kastner Source Type: research

Expression Profile, Molecular Association, and Clinical Significance of POLD4 in Glioblastoma
In conclusion, POLD4 is significantly upregulated in glioblastoma and may be used as a potential diagnostic or prognostic biomarker for GBM patients. However, to establish the same a large cohort study is needed. Using TCGA data and various cancer bioinformatics tools mentioned above we observed very high level of gene and protein expression of POLD4 in glioblastoma patients. The expression of POLD4 was significantly correlated with inflammatory and oncogenic pathways and it also has a significant correlation with adverse outcome in patients with glioblastoma.PMID:37543966 | DOI:10.1007/s10571-023-01393-x (Source: Cellular...
Source: Cellular and Molecular Neurobiology - August 6, 2023 Category: Cytology Authors: Md Tanjim Alam Mohammad Shadab Ali Harsh Goel Jay Singh Bilash Chatterjee Subhankar Bose Vijay Hadda Anita Chopra Source Type: research

Primary Hypothyroidism and Alzheimer's Disease: A Tale of Two
Cell Mol Neurobiol. 2023 Aug 4. doi: 10.1007/s10571-023-01392-y. Online ahead of print.ABSTRACTHypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer's disease (AD). In addition, progressive neurodegeneration in AD may affect the metabolism of thyroid hormones (THs) in the brain causing local brain HPT. Hence, the present review aimed to clarify the potential association between HPT and AD. HPT promotes the progression of AD by inducing the production of amyloid beta (Aβ) and tau protein phosphorylation with the development of synaptic plasticity and memory dysfunction. Besides, t...
Source: Cellular and Molecular Neurobiology - August 4, 2023 Category: Cytology Authors: Faisal Holil AlAnazi Hayder M Al-Kuraishy Athanasios Alexiou Marios Papadakis Mohamed H Mazhar Ashour Saud A Alnaaim Omnya Elhussieny Hebatallah M Saad Gaber El-Saber Batiha Source Type: research