Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia
Cell Mol Neurobiol. 2023 Oct 6. doi: 10.1007/s10571-023-01415-8. Online ahead of print.ABSTRACTHypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the context of energy metabolism, is controlled by extracellular concentration of purines, regulated by ecto-enzymes, such as e-NTPDase-1/CD39, ecto-5'-NT/CD73, and eADA. We hypothesize that hypercholesterolemia, via modulation of the activity of nucleotide metabolism-regulating ecto-enzymes, deteriorates glycolytic efficiency and energy metabolism of endothelial cells, which may potentiall...
Source: Cellular and Molecular Neurobiology - October 6, 2023 Category: Cytology Authors: Ewelina Czuba-Paku ła Iwona Pelikant-Ma łecka Gra żyna Lietzau S ławomir Wójcik Ryszard T Smole ński Przemys ław Kowiański Source Type: research

Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia
Cell Mol Neurobiol. 2023 Oct 6. doi: 10.1007/s10571-023-01415-8. Online ahead of print.ABSTRACTHypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the context of energy metabolism, is controlled by extracellular concentration of purines, regulated by ecto-enzymes, such as e-NTPDase-1/CD39, ecto-5'-NT/CD73, and eADA. We hypothesize that hypercholesterolemia, via modulation of the activity of nucleotide metabolism-regulating ecto-enzymes, deteriorates glycolytic efficiency and energy metabolism of endothelial cells, which may potentiall...
Source: Cellular and Molecular Neurobiology - October 6, 2023 Category: Cytology Authors: Ewelina Czuba-Paku ła Iwona Pelikant-Ma łecka Gra żyna Lietzau S ławomir Wójcik Ryszard T Smole ński Przemys ław Kowiański Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997-2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hot...
Source: Cellular and Molecular Neurobiology - September 26, 2023 Category: Cytology Authors: Caixia Zhang Mi Zhang Xueqin Cao Bo Jiao Wencui Zhang Shangchen Yu Xianwei Zhang Source Type: research

Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/ β-Catenin and PI3K/AKT Signaling Pathways
Cell Mol Neurobiol. 2023 Sep 25. doi: 10.1007/s10571-023-01414-9. Online ahead of print.ABSTRACTGliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most aggressive type. The clinical prognosis of GBM patients remains bleak despite the availability of multiple options for therapy, which has needed us to explore new therapeutic methods to face the rapid progression, short survival, and therapy resistance of glioblastomas. As the Human Genome Project advances, long noncoding RNAs (lncRNAs) have attracted the attention of researchers and clinicians in cancer rese...
Source: Cellular and Molecular Neurobiology - September 25, 2023 Category: Cytology Authors: Hanyun Li Jilan Liu Xianyun Qin Jikui Sun Yan Liu Feng Jin Source Type: research

The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
In this study, a selective mTOR inhibitor, everolimus, was applied to investigate the outcome after ICH and the possible underlying mechanism. The ICH model was established by autologous blood injection. Everolimus (50 and 100 µg/kg) was administered intraperitoneally for 14 consecutive days' post-operation. The neurological functions were examined at 3, 7, and 14 days' post-ICH. Samples of brain tissue were collected to perform histopathological and immunohistochemical (NF-k-positive cell) examinations. Besides, the striatum was used to evaluate parameters related to oxidative stress (superoxide dismutase (SOD) activity,...
Source: Cellular and Molecular Neurobiology - September 25, 2023 Category: Cytology Authors: Shima Shirzad Farzaneh Vafaee Fatemeh Forouzanfar Source Type: research

Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/ β-Catenin and PI3K/AKT Signaling Pathways
Cell Mol Neurobiol. 2023 Sep 25. doi: 10.1007/s10571-023-01414-9. Online ahead of print.ABSTRACTGliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most aggressive type. The clinical prognosis of GBM patients remains bleak despite the availability of multiple options for therapy, which has needed us to explore new therapeutic methods to face the rapid progression, short survival, and therapy resistance of glioblastomas. As the Human Genome Project advances, long noncoding RNAs (lncRNAs) have attracted the attention of researchers and clinicians in cancer rese...
Source: Cellular and Molecular Neurobiology - September 25, 2023 Category: Cytology Authors: Hanyun Li Jilan Liu Xianyun Qin Jikui Sun Yan Liu Feng Jin Source Type: research

The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
In this study, a selective mTOR inhibitor, everolimus, was applied to investigate the outcome after ICH and the possible underlying mechanism. The ICH model was established by autologous blood injection. Everolimus (50 and 100 µg/kg) was administered intraperitoneally for 14 consecutive days' post-operation. The neurological functions were examined at 3, 7, and 14 days' post-ICH. Samples of brain tissue were collected to perform histopathological and immunohistochemical (NF-k-positive cell) examinations. Besides, the striatum was used to evaluate parameters related to oxidative stress (superoxide dismutase (SOD) activity,...
Source: Cellular and Molecular Neurobiology - September 25, 2023 Category: Cytology Authors: Shima Shirzad Farzaneh Vafaee Fatemeh Forouzanfar Source Type: research

N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model
Cell Mol Neurobiol. 2023 Sep 24. doi: 10.1007/s10571-023-01410-z. Online ahead of print.ABSTRACTStatus epilepticus (SE) is described as continuous and self-sustaining seizures, which triggers hippocampal neurodegeneration, inflammation, and gliosis. N-formyl peptide receptor (FPR) has been associated with inflammatory process. N-formyl-methionyl-leucyl-phenylalanine (fMLP) peptide plays an anti-inflammatory role, mediated by the activation of G-protein-coupled FPR. Here, we evaluated the influence of fMLP peptides on the behavior of limbic seizures, memory consolidation, and hippocampal neurodegeneration process. Male Wist...
Source: Cellular and Molecular Neurobiology - September 24, 2023 Category: Cytology Authors: Igor Santana de Melo Robinson Sabino-Silva Maisa Ara újo Costa Em ília Rezende Vaz Cassius Iury Anselmo-E-Silva Thain á de Paula Soares Mendonça Kellysson Bruno Oliveira Fernanda Maria Ara újo de Souza Yngrid Mickaelli Oliveira Dos Santos Amanda Lari Source Type: research