Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network
In this study, we aimed to identify a gene expression signature using an artificial neural network (ANN) in application to microarray and serial analysis of gene expression (SAGE) data for grade 3 (AG) and grade 4 (GBM) gliomas discrimination. We acquired gene expression data from publicly available datasets on glial tumors of grades 3 and 4-a total of 93 grade 3 gliomas and 224 grade 4 gliomas. To select genes for classification, we implemented an artificial neural network-based method using a combination of self-organized maps (SOM) and perceptron. In general, we implemented a multi-stage procedure that involved multiple...
Source: Cellular and Molecular Neurobiology - December 27, 2023 Category: Cytology Authors: Aleksei A Mekler Dmitry R Schwartz Olga E Savelieva Source Type: research

Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology
Cell Mol Neurobiol. 2023 Dec 27;44(1):12. doi: 10.1007/s10571-023-01447-0.ABSTRACTIntracranial vascular malformations manifest on a continuum ranging from predominantly arterial to predominantly venous in pathology. Cerebral cavernous malformations (CCMs) are capillary malformations that exist at the midpoint of this continuum. The axon guidance factor Ephrin B2 and its receptor EphB4 are critical regulators of vasculogenesis in the developing central nervous system. Ephrin B2/EphB4 dysregulation has been implicated in the pathogenesis of arterial-derived arteriovenous malformations and vein-based vein of Galen malformatio...
Source: Cellular and Molecular Neurobiology - December 27, 2023 Category: Cytology Authors: Julie Sesen Aram Ghalali Jessica Driscoll Tyra Martinez Adrien Lupieri David Zurakowski Sanda Alexandrescu Edward R Smith Katie P Fehnel Source Type: research

Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
Cell Mol Neurobiol. 2023 Dec 27;44(1):11. doi: 10.1007/s10571-023-01442-5.ABSTRACTThe adult peripheral nervous system has a significant ability for regeneration compared to the central nervous system. This is related to the unique neuroimmunomodulation after peripheral nerve injury (PNI). Unlike the repair of other tissues after injury, Schwann cells (SCs) respond immediately to the trauma and send out signals to precisely recruit macrophages to the injured site. Then, macrophages promote the degradation of the damaged myelin sheath by phagocytosis of local debris. At the same time, macrophages and SCs jointly secrete vari...
Source: Cellular and Molecular Neurobiology - December 27, 2023 Category: Cytology Authors: Guanggeng Wu Xiaoyue Wen Rui Kuang KoonHei Winson Lui Bo He Ge Li Zhaowei Zhu Source Type: research

Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures
Cell Mol Neurobiol. 2023 Dec 23;44(1):10. doi: 10.1007/s10571-023-01445-2.ABSTRACTRhythmic regulations are virtually described in all physiological processes, including central nervous system development and immunologic responses. Zika virus (ZIKV), a neurotropic arbovirus, has been recently linked to a series of birth defects and neurodevelopmental disorders. Given the well-characterized role of the intrinsic cellular circadian clock within neurogenesis, cellular metabolism, migration, and differentiation among other processes, this study aimed to characterize the influence of ZIKV infection in the circadian clock express...
Source: Cellular and Molecular Neurobiology - December 23, 2023 Category: Cytology Authors: Tha íse Yasmine Vasconcelos de Lima Cavalcanti Morganna Costa Lima Paula Bargi-Souza Rafael Freitas Oliveira Franca Rodrigo Antonio Peliciari-Garcia Source Type: research