Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Cell Mol Neurobiol. 2024 Feb 23;44(1):25. doi: 10.1007/s10571-024-01457-6.ABSTRACTFerroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory amino acids, and the inflammatory response after ...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Xinjuan Tian Xiang Li Mengtian Pan Lele Zixin Yang Yunman Li Weirong Fang Source Type: research

Iron Deposition in Parkinson's Disease: A Mini-Review
Cell Mol Neurobiol. 2024 Feb 23;44(1):26. doi: 10.1007/s10571-024-01459-4.ABSTRACTIron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulat...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Weiqi Zeng Jin Cai Lei Zhang Qiwei Peng Source Type: research

Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Cell Mol Neurobiol. 2024 Feb 23;44(1):25. doi: 10.1007/s10571-024-01457-6.ABSTRACTFerroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory amino acids, and the inflammatory response after ...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Xinjuan Tian Xiang Li Mengtian Pan Lele Zixin Yang Yunman Li Weirong Fang Source Type: research

Iron Deposition in Parkinson's Disease: A Mini-Review
Cell Mol Neurobiol. 2024 Feb 23;44(1):26. doi: 10.1007/s10571-024-01459-4.ABSTRACTIron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulat...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Weiqi Zeng Jin Cai Lei Zhang Qiwei Peng Source Type: research

Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Cell Mol Neurobiol. 2024 Feb 23;44(1):25. doi: 10.1007/s10571-024-01457-6.ABSTRACTFerroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory amino acids, and the inflammatory response after ...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Xinjuan Tian Xiang Li Mengtian Pan Lele Zixin Yang Yunman Li Weirong Fang Source Type: research

Iron Deposition in Parkinson's Disease: A Mini-Review
Cell Mol Neurobiol. 2024 Feb 23;44(1):26. doi: 10.1007/s10571-024-01459-4.ABSTRACTIron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulat...
Source: Cellular and Molecular Neurobiology - February 23, 2024 Category: Cytology Authors: Weiqi Zeng Jin Cai Lei Zhang Qiwei Peng Source Type: research

A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells
Cell Mol Neurobiol. 2024 Feb 19;44(1):24. doi: 10.1007/s10571-024-01460-x.ABSTRACTNeuroinflammation is an important pathogenesis of neurological diseases and causes a series of physiopathological changes, such as abnormal activation of glial cells, neuronal degeneration and death, and disruption of the blood‒brain barrier. Therefore, modulating inflammation may be an important therapeutic tool for treating neurological diseases. Mesenchymal stem cells (MSCs), as pluripotent stem cells, have great therapeutic potential for neurological diseases due to their regenerative ability, immunity, and ability to regulate inflammat...
Source: Cellular and Molecular Neurobiology - February 19, 2024 Category: Cytology Authors: Ying Ge Jingjing Wu Li Zhang Nanqu Huang Yong Luo Source Type: research

A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells
Cell Mol Neurobiol. 2024 Feb 19;44(1):24. doi: 10.1007/s10571-024-01460-x.ABSTRACTNeuroinflammation is an important pathogenesis of neurological diseases and causes a series of physiopathological changes, such as abnormal activation of glial cells, neuronal degeneration and death, and disruption of the blood‒brain barrier. Therefore, modulating inflammation may be an important therapeutic tool for treating neurological diseases. Mesenchymal stem cells (MSCs), as pluripotent stem cells, have great therapeutic potential for neurological diseases due to their regenerative ability, immunity, and ability to regulate inflammat...
Source: Cellular and Molecular Neurobiology - February 19, 2024 Category: Cytology Authors: Ying Ge Jingjing Wu Li Zhang Nanqu Huang Yong Luo Source Type: research

A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells
Cell Mol Neurobiol. 2024 Feb 19;44(1):24. doi: 10.1007/s10571-024-01460-x.ABSTRACTNeuroinflammation is an important pathogenesis of neurological diseases and causes a series of physiopathological changes, such as abnormal activation of glial cells, neuronal degeneration and death, and disruption of the blood‒brain barrier. Therefore, modulating inflammation may be an important therapeutic tool for treating neurological diseases. Mesenchymal stem cells (MSCs), as pluripotent stem cells, have great therapeutic potential for neurological diseases due to their regenerative ability, immunity, and ability to regulate inflammat...
Source: Cellular and Molecular Neurobiology - February 19, 2024 Category: Cytology Authors: Ying Ge Jingjing Wu Li Zhang Nanqu Huang Yong Luo Source Type: research

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
The objective of this timely review is not only to outline the multifaceted pathogenic roles of HOTAIR in the development and pathophysiology of gliomas and brain cancers, but also to delineate the research findings implicating it as a critical regulator of overall brain pathophysiology. While the major focus is on neuro-oncology, wherein HOTAIR represents a particularly potent underlying pathogenic player and a suitable therapeutic target, mechanisms underlying the regulatory actions of HOTAIR in neurodegeneration, traumatic, hypoxic and ischemic brain injuries, and neuropsychiatric disorders are also presented.PMID:38366...
Source: Cellular and Molecular Neurobiology - February 17, 2024 Category: Cytology Authors: Faraz Ahmad Ravi Sudesh A Toufeeq Ahmed Shafiul Haque Source Type: research

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
The objective of this timely review is not only to outline the multifaceted pathogenic roles of HOTAIR in the development and pathophysiology of gliomas and brain cancers, but also to delineate the research findings implicating it as a critical regulator of overall brain pathophysiology. While the major focus is on neuro-oncology, wherein HOTAIR represents a particularly potent underlying pathogenic player and a suitable therapeutic target, mechanisms underlying the regulatory actions of HOTAIR in neurodegeneration, traumatic, hypoxic and ischemic brain injuries, and neuropsychiatric disorders are also presented.PMID:38366...
Source: Cellular and Molecular Neurobiology - February 17, 2024 Category: Cytology Authors: Faraz Ahmad Ravi Sudesh A Toufeeq Ahmed Shafiul Haque Source Type: research

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
The objective of this timely review is not only to outline the multifaceted pathogenic roles of HOTAIR in the development and pathophysiology of gliomas and brain cancers, but also to delineate the research findings implicating it as a critical regulator of overall brain pathophysiology. While the major focus is on neuro-oncology, wherein HOTAIR represents a particularly potent underlying pathogenic player and a suitable therapeutic target, mechanisms underlying the regulatory actions of HOTAIR in neurodegeneration, traumatic, hypoxic and ischemic brain injuries, and neuropsychiatric disorders are also presented.PMID:38366...
Source: Cellular and Molecular Neurobiology - February 17, 2024 Category: Cytology Authors: Faraz Ahmad Ravi Sudesh A Toufeeq Ahmed Shafiul Haque Source Type: research

Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
This study investigates the expression of CGRP in the trigeminal ganglion (TG) and its regulatory role in the polarization of macrophages in rats with temporomandibular arthritis. A rat model of temporomandibular arthritis was established using CFA. Pain behavior was then observed. Temporomandibular joint (TMJ) and the TG were collected, and immunohistochemistry, immunofluorescence (IF) staining, and RT-qPCR were used to examine the expression of CGRP and macrophage-related factors. To investigate the impact of CGRP on macrophage polarization, both CGRP and its antagonist, CGRP 8-37, were separately administered directly w...
Source: Cellular and Molecular Neurobiology - February 16, 2024 Category: Cytology Authors: Junli Tao Xiaohui Wang Jie Xu Source Type: research

Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
This study investigates the expression of CGRP in the trigeminal ganglion (TG) and its regulatory role in the polarization of macrophages in rats with temporomandibular arthritis. A rat model of temporomandibular arthritis was established using CFA. Pain behavior was then observed. Temporomandibular joint (TMJ) and the TG were collected, and immunohistochemistry, immunofluorescence (IF) staining, and RT-qPCR were used to examine the expression of CGRP and macrophage-related factors. To investigate the impact of CGRP on macrophage polarization, both CGRP and its antagonist, CGRP 8-37, were separately administered directly w...
Source: Cellular and Molecular Neurobiology - February 16, 2024 Category: Cytology Authors: Junli Tao Xiaohui Wang Jie Xu Source Type: research

Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review
Cell Mol Neurobiol. 2024 Feb 13;44(1):21. doi: 10.1007/s10571-024-01454-9.ABSTRACTIt is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through in vitro studies. However, recent in vivo studies on the function of microglia have questioned the two-phase paradigm; therefore, a change in the frequency of in vitro studies is expected. A systematic review was carried out to identify the microglial cytokine profile against viral infection th...
Source: Cellular and Molecular Neurobiology - February 13, 2024 Category: Cytology Authors: Diego A Barrios-Gonz ález Santiago Philibert-Rosas Iris E Mart ínez-Juárez Fernando Sotelo-D íaz Ver ónica Rivas-Alonso Julio Sotelo Mario A Sebasti án-Díaz Source Type: research