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REST in the Road Map of Brain Development
Cell Mol Neurobiol. 2023 Jul 30. doi: 10.1007/s10571-023-01394-w. Online ahead of print.ABSTRACTRepressor element-1 silencing transcription factor (REST) or also known as neuron-restrictive silencing factor (NRSF), is the key initiator of epigenetic neuronal gene-expression modification. Identification of a massive number of REST-targeted genes in the brain signifies its broad involvement in maintaining the functionality of the nervous system. Additionally, REST plays a crucial role in conferring neuroprotection to the neurons against various stressors or insults during injuries. At the cellular level, nuclear localisation...
Source: Cellular and Molecular Neurobiology - July 30, 2023 Category: Cytology Authors: Xin-Jieh Lam Sandra Maniam Pike-See Cheah King-Hwa Ling Source Type: research

REST in the Road Map of Brain Development
Cell Mol Neurobiol. 2023 Jul 30. doi: 10.1007/s10571-023-01394-w. Online ahead of print.ABSTRACTRepressor element-1 silencing transcription factor (REST) or also known as neuron-restrictive silencing factor (NRSF), is the key initiator of epigenetic neuronal gene-expression modification. Identification of a massive number of REST-targeted genes in the brain signifies its broad involvement in maintaining the functionality of the nervous system. Additionally, REST plays a crucial role in conferring neuroprotection to the neurons against various stressors or insults during injuries. At the cellular level, nuclear localisation...
Source: Cellular and Molecular Neurobiology - July 30, 2023 Category: Cytology Authors: Xin-Jieh Lam Sandra Maniam Pike-See Cheah King-Hwa Ling Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research

MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate the occurrence of neuroinflammation. We here reported that the decreased levels of miR-338-3p were detected using qRT-PCR and the upregulated expression of TNF-α and IL-1β was measured by ELISA in the cerebrospinal fluid (CSF) in patients with ICI. A negative association between miR-338-3p and TNF-α or IL-1β was revealed by Pearson correlation analysis. Sprague-Dawley (SD) rats were injected with LPS (50 μg) into left cerebral ventricule (LCV), following which the increased expression of TNF-α and IL-1β and the reduction ...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Nan Liu Qiuping Zhou Huifang Wang Qian Li Zhuo Chen Yiyan Lin Lingling Yi Shuqi Jiang Chunbo Chen Yiyu Deng Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research

MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate the occurrence of neuroinflammation. We here reported that the decreased levels of miR-338-3p were detected using qRT-PCR and the upregulated expression of TNF-α and IL-1β was measured by ELISA in the cerebrospinal fluid (CSF) in patients with ICI. A negative association between miR-338-3p and TNF-α or IL-1β was revealed by Pearson correlation analysis. Sprague-Dawley (SD) rats were injected with LPS (50 μg) into left cerebral ventricule (LCV), following which the increased expression of TNF-α and IL-1β and the reduction ...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Nan Liu Qiuping Zhou Huifang Wang Qian Li Zhuo Chen Yiyan Lin Lingling Yi Shuqi Jiang Chunbo Chen Yiyu Deng Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research

MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate the occurrence of neuroinflammation. We here reported that the decreased levels of miR-338-3p were detected using qRT-PCR and the upregulated expression of TNF-α and IL-1β was measured by ELISA in the cerebrospinal fluid (CSF) in patients with ICI. A negative association between miR-338-3p and TNF-α or IL-1β was revealed by Pearson correlation analysis. Sprague-Dawley (SD) rats were injected with LPS (50 μg) into left cerebral ventricule (LCV), following which the increased expression of TNF-α and IL-1β and the reduction ...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Nan Liu Qiuping Zhou Huifang Wang Qian Li Zhuo Chen Yiyan Lin Lingling Yi Shuqi Jiang Chunbo Chen Yiyu Deng Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research

MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate the occurrence of neuroinflammation. We here reported that the decreased levels of miR-338-3p were detected using qRT-PCR and the upregulated expression of TNF-α and IL-1β was measured by ELISA in the cerebrospinal fluid (CSF) in patients with ICI. A negative association between miR-338-3p and TNF-α or IL-1β was revealed by Pearson correlation analysis. Sprague-Dawley (SD) rats were injected with LPS (50 μg) into left cerebral ventricule (LCV), following which the increased expression of TNF-α and IL-1β and the reduction ...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Nan Liu Qiuping Zhou Huifang Wang Qian Li Zhuo Chen Yiyan Lin Lingling Yi Shuqi Jiang Chunbo Chen Yiyu Deng Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research

MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate the occurrence of neuroinflammation. We here reported that the decreased levels of miR-338-3p were detected using qRT-PCR and the upregulated expression of TNF-α and IL-1β was measured by ELISA in the cerebrospinal fluid (CSF) in patients with ICI. A negative association between miR-338-3p and TNF-α or IL-1β was revealed by Pearson correlation analysis. Sprague-Dawley (SD) rats were injected with LPS (50 μg) into left cerebral ventricule (LCV), following which the increased expression of TNF-α and IL-1β and the reduction ...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Nan Liu Qiuping Zhou Huifang Wang Qian Li Zhuo Chen Yiyan Lin Lingling Yi Shuqi Jiang Chunbo Chen Yiyu Deng Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research

MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate the occurrence of neuroinflammation. We here reported that the decreased levels of miR-338-3p were detected using qRT-PCR and the upregulated expression of TNF-α and IL-1β was measured by ELISA in the cerebrospinal fluid (CSF) in patients with ICI. A negative association between miR-338-3p and TNF-α or IL-1β was revealed by Pearson correlation analysis. Sprague-Dawley (SD) rats were injected with LPS (50 μg) into left cerebral ventricule (LCV), following which the increased expression of TNF-α and IL-1β and the reduction ...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Nan Liu Qiuping Zhou Huifang Wang Qian Li Zhuo Chen Yiyan Lin Lingling Yi Shuqi Jiang Chunbo Chen Yiyu Deng Source Type: research

Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Cell Mol Neurobiol. 2023 Jul 21. doi: 10.1007/s10571-023-01390-0. Online ahead of print.ABSTRACTErythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of receptor tyrosine kinases (RTKs). It serves a crucial role in both physiological, biological, and functional states binding with their ligand like Ephrins. Its abundance in the majority of the body's systems has been reported. Moreover, it draws much attention in the CNS since it influences axonal and vascular guidance. Also, it has a widespread role at the pathological state of various...
Source: Cellular and Molecular Neurobiology - July 21, 2023 Category: Cytology Authors: Meenal Verma Manjeet Chopra Hemant Kumar Source Type: research