MiR-4319 targets tuftelin 1 to reduce malignancy of cervical cancer cells
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):54-60. doi: 10.14715/cmb/2024.70.3.8.ABSTRACTCervical cancer (CC) is the most common malignant tumor of female reproductive system. MiR-4319 has been identified as an anti-oncogene in various cancers. In the present study, role of miR-4319 in CC was identified. Colony formation, flow cytometer, wound healing, and transwell assays were used to detect CC cell proliferation, apoptosis, migration, and invasion. The expression of miR-4319 was decreased in clinical CC tissues and CC cell lines. Upregulation of miR-4319 suppressed cell viability, proliferation, migration, and inva...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Lijun Zheng Qiongzhen Ren Weipei Zhu Xiaomin Tao Liangsheng Guo Source Type: research
Identification of small molecule inhibitors of penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus for the therapeutics of bacterial infection
In conclusion, the results suggest alpha-mangostin as a promising candidate for inhibiting PBP2a. Further, extensive studies are warranted to explore its clinical applications.PMID:38650157 | DOI:10.14715/cmb/2024.70.3.6 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Anwer Razique Source Type: research
Clinical value of KiSS-1 and MMP-2 expression levels in breast cancer tissue in evaluating prognosis of elderly breast cancer patients after modified radical mastectomy
In conclusion, KiSS-1 and MMP-2 levels in BC tissue possess relation to adverse prognosis of MCM. KiSS-1 and MMP-2 levels in elderly BC patients before surgery may be detected in the future to assist in prognosis evaluation of elderly BC patients after MCM.PMID:38650158 | DOI:10.14715/cmb/2024.70.3.38 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jiyang Lv Junya Zhang Fangfang Wu Source Type: research
In vivo determination of the anti-inflammatory and antioxidant effects of the aqueous extract of Syzygium aromaticum (clove) in an asthmatic rat model
This study aimed to evaluate the anti-inflammatory and antioxidant effects of an Aqueous Extract of Clove (AEC) Syzygium aromaticum on the lungs and erythrocytes of an experimental asthma model in Wistar rats. For this purpose, four groups of male rats were examined: control, sensitized with ovalbumin (OVA), treated with AEC, and treated with a combination of OVA/AEC. After treatment, the antioxidant effect was determined by measuring the malondialdehyde (MDA), glutathione peroxidase (GPx), glutathione (GSH), and catalase (CAT) levels. The anti-inflammatory effect was determined by measuring IL-4 levels by performing enzym...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Lynda Sabrina Ounaceur Mahfoud Messarah Abdelaziz Lankar Djihane Touaibia Hanene Ghadab Zohir Garri Sonia Boudjil Khadidja Belkacem Djeffel Latifa Atoui Anis Ounaceur Nesrine Djaber Amel Boumendjel Source Type: research
Effect of NAMPT on the proliferation and apoptosis in odontoblast-like MDPC-23 cell
This study aimed to evaluate the physiological role of NAMPT associated with MDPC-23 odontoblast cell proliferation. Cell viability was measured using the (DAPI) staining, caspase activation analysis and immunoblotting were performed. Visfatin promoted MDPC-23 odontoblast cell growth in a dose-dependent manner. Furthermore, the up-regulation of Visfatin promoted odontogenic differentiation and accelerated mineralization through an increase in representative odontoblastic biomarkers in MDPC-23 cells. However, FK-866 cell growth in a dose-dependent manner induced nuclear condensation and fragmentation. FK-866-treated cells s...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Kyeong-Rok Kang Joo-Cheol Park Chun Sung Kim Heung-Joong Kim Sun-Kyoung Yu Hong Sung Chun HyangI Lim Jeong-Yeon Seo Jae-Sung Kim Do Kyung Kim Source Type: research
The tumor suppressor effect of miRNA 200-c-3p on A549 non-small cell lung cancer cell line is associated with down-regulation of programmed cell death ligand 1; an immune-check point mechanism
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):13-21. doi: 10.14715/cmb/2024.70.3.3.ABSTRACTMiRNA 200-c-3p has varying functions in different tumor types, whether tumor suppression or promotion. Comprehensive assessment of its function in non-small cell lung cancer (NSCLC) together with its effect on antitumor immune response have not been declared before. We aimed to explore the effect of replacement and suppression of miRNA 200-c-3p on non-small cell lung cancer and its impact on immune checkpoint function and subsequently antitumor immunity. MiRNA 200-c-3p mimic/inhibitor was transfected into the A549 cells. A 549 no...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Sara Ezzat None Magda I Mohamad None Manal Basyouni Ahmed None Sara Elsayed Abdelrahman None Nesma Hussein Abdel Hay None Nashwa El-Khazragy None Maha Imam Ismail Source Type: research
E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population
This study was conducted on 200 participants who were admitted to the surgical specialty hospital-cardiac center in Erbil City, Iraq between October 2021 and May 2022. Based on the outcomes of the clinical examination, laboratory tests, coronary angiography (COA), acute myocardial infarction (MI) type ST-elevation myocardial infarction (STEMI), stable angina pectoris (SAP), and healthy control groups were tested. Each sample was subjected to Sanger sequencing. The polymorphism was significantly linked to stable angina and myocardial infarction Genotype CC was higher in SAP when compared with MI and control groups which was...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Lajan Qasim Rahman Ruqaya Muhammad Ghareeb Source Type: research
Association of IL-1 β 542 T & gt;A gene polymorphism with Recurrent Aphthous Stomatitis in Erbil City population
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):7-12. doi: 10.14715/cmb/2024.70.3.2.ABSTRACTRecurrent Aphthous stomatitis (RAS) is common oral mucosal condition. The pathophysiology of RAS is affected by a variety of variables, including microbial, genetic, immunological and local and systemic diseases. Interleukin IL-1β, a cytokine that promotes inflammation, has been found in high concentrations in the circulation of RAS. The goal of current investigation was to determine whether RAS is connected with polymorphisms of the IL-1β 542 T>A gene. A total of 60 RAS patients and 30 controls were included in the study. Bi...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Asma Qasim Rahman Reiadh Kamal Al-Kamali Source Type: research
Pathological characteristics and long-term prognosis of submucosal infiltrating carcinoma of the colon and rectum below 2 cm confirmed by endoscopic submucosal dissection
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):275-280. doi: 10.14715/cmb/2024.70.2.38.ABSTRACTThe purpose of this study was to explore the correlation between additional surgery and the clinicopathological characteristics of colorectal cancer, as well as its impact on patient prognosis. A total of 119 patients with early colorectal cancer were selected and divided into an additional surgery group (28 cases) and a non-additional surgery group (91 cases). According to the tumor size, the patients were further divided into a large diameter group (54 cases, d≥1 cm and <2 cm) and a small diameter group (65 cases, d<...
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Jun Zhou Tingsheng Ling Jun Xiao Qide Zhang Lei Wang Source Type: research
The effects of laparoscopic and laparotomy extensive hysterectomy on the safety of ureterovaginal fistula infection in patients with cervical cancer
In conclusion, both laparoscopic and laparotomy extensive hysterectomy may lead to ureterovaginal fistula infection in patients with cervical cancer. However, compared with laparotomy extensive hysterectomy, laparoscopic extensive hysterectomy had higher safety and significantly improved the quality of life of patients, which was worthy of popularization and application in clinical practice.PMID:38431837 | DOI:10.14715/cmb/2024.70.2.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Hongge Xu Hongyan Ding Qianqian Ge Can Shi Source Type: research
Clinical efficacy of early microsurgical clipping of tumor neck in the treatment of cerebral aneurysm rupture and bleeding and its impact on oxidative stress response and prognosis of patients
In conclusion, early microsurgical clipping of the tumor neck can reduce the risk of complications and cognitive impairment in patients with cerebral aneurysm rupture and bleeding.PMID:38431838 | DOI:10.14715/cmb/2024.70.2.40 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Zhenglou Chen Hongsheng Wang Min Xu Yunjiang Wang Xuqi Hu Source Type: research
Pathological characteristics and long-term prognosis of submucosal infiltrating carcinoma of the colon and rectum below 2 cm confirmed by endoscopic submucosal dissection
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):275-280. doi: 10.14715/cmb/2024.70.2.38.ABSTRACTThe purpose of this study was to explore the correlation between additional surgery and the clinicopathological characteristics of colorectal cancer, as well as its impact on patient prognosis. A total of 119 patients with early colorectal cancer were selected and divided into an additional surgery group (28 cases) and a non-additional surgery group (91 cases). According to the tumor size, the patients were further divided into a large diameter group (54 cases, d≥1 cm and <2 cm) and a small diameter group (65 cases, d<...
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Jun Zhou Tingsheng Ling Jun Xiao Qide Zhang Lei Wang Source Type: research
The effects of laparoscopic and laparotomy extensive hysterectomy on the safety of ureterovaginal fistula infection in patients with cervical cancer
In conclusion, both laparoscopic and laparotomy extensive hysterectomy may lead to ureterovaginal fistula infection in patients with cervical cancer. However, compared with laparotomy extensive hysterectomy, laparoscopic extensive hysterectomy had higher safety and significantly improved the quality of life of patients, which was worthy of popularization and application in clinical practice.PMID:38431837 | DOI:10.14715/cmb/2024.70.2.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Hongge Xu Hongyan Ding Qianqian Ge Can Shi Source Type: research
Clinical efficacy of early microsurgical clipping of tumor neck in the treatment of cerebral aneurysm rupture and bleeding and its impact on oxidative stress response and prognosis of patients
In conclusion, early microsurgical clipping of the tumor neck can reduce the risk of complications and cognitive impairment in patients with cerebral aneurysm rupture and bleeding.PMID:38431838 | DOI:10.14715/cmb/2024.70.2.40 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Zhenglou Chen Hongsheng Wang Min Xu Yunjiang Wang Xuqi Hu Source Type: research
Pathological characteristics and long-term prognosis of submucosal infiltrating carcinoma of the colon and rectum below 2 cm confirmed by endoscopic submucosal dissection
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):275-280. doi: 10.14715/cmb/2024.70.2.38.ABSTRACTThe purpose of this study was to explore the correlation between additional surgery and the clinicopathological characteristics of colorectal cancer, as well as its impact on patient prognosis. A total of 119 patients with early colorectal cancer were selected and divided into an additional surgery group (28 cases) and a non-additional surgery group (91 cases). According to the tumor size, the patients were further divided into a large diameter group (54 cases, d≥1 cm and <2 cm) and a small diameter group (65 cases, d<...
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Jun Zhou Tingsheng Ling Jun Xiao Qide Zhang Lei Wang Source Type: research
