Pathological characteristics and long-term prognosis of submucosal infiltrating carcinoma of the colon and rectum below 2 cm confirmed by endoscopic submucosal dissection
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):275-280. doi: 10.14715/cmb/2024.70.2.38.ABSTRACTThe purpose of this study was to explore the correlation between additional surgery and the clinicopathological characteristics of colorectal cancer, as well as its impact on patient prognosis. A total of 119 patients with early colorectal cancer were selected and divided into an additional surgery group (28 cases) and a non-additional surgery group (91 cases). According to the tumor size, the patients were further divided into a large diameter group (54 cases, d≥1 cm and <2 cm) and a small diameter group (65 cases, d<...
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Jun Zhou Tingsheng Ling Jun Xiao Qide Zhang Lei Wang Source Type: research
The effects of laparoscopic and laparotomy extensive hysterectomy on the safety of ureterovaginal fistula infection in patients with cervical cancer
In conclusion, both laparoscopic and laparotomy extensive hysterectomy may lead to ureterovaginal fistula infection in patients with cervical cancer. However, compared with laparotomy extensive hysterectomy, laparoscopic extensive hysterectomy had higher safety and significantly improved the quality of life of patients, which was worthy of popularization and application in clinical practice.PMID:38431837 | DOI:10.14715/cmb/2024.70.2.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Hongge Xu Hongyan Ding Qianqian Ge Can Shi Source Type: research
Clinical efficacy of early microsurgical clipping of tumor neck in the treatment of cerebral aneurysm rupture and bleeding and its impact on oxidative stress response and prognosis of patients
In conclusion, early microsurgical clipping of the tumor neck can reduce the risk of complications and cognitive impairment in patients with cerebral aneurysm rupture and bleeding.PMID:38431838 | DOI:10.14715/cmb/2024.70.2.40 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 3, 2024 Category: Molecular Biology Authors: Zhenglou Chen Hongsheng Wang Min Xu Yunjiang Wang Xuqi Hu Source Type: research
The role of mir96 in predicting CTC status and prognostic evaluation in gastric cancer patients
In conclusion, the present study demonstrated that the Cell Rich TM system combined with the negative enrichment strategy can effectively detect CTCs in the peripheral blood of gastric cancer patients and that the expression of miR-96 can be used as an effective indicator to predict CTC status and assist in determining the prognosis of gastric cancer. These findings have important implications for the diagnosis and treatment of gastric cancer and provide new clues for the further study of the tumor immune microenvironment and tumor heterogeneity.PMID:38430012 | DOI:10.14715/cmb/2024.70.2.37 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Qi Zheng Haiyan Ge Source Type: research
Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1/SIRT3-FOXO3a axis
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):257-263. doi: 10.14715/cmb/2024.70.2.36.ABSTRACTGranulosa cells are somatic cells located inside follicles that play a crucial role in the growth and development of follicles. Quercetin and tanshinone are two key monomers in traditional Chinese medicine that have antioxidant and anti-aging properties. The KGN cell apoptosis model caused by triptolide (TP) was employed in this work to investigate granulosa cell death and medication rescue. Quercetin and tanshinone therapy suppressed KGN cell death and oxidation while also regulating the expression of critical apoptosis and o...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Qingzhi Wan Lisha Tang Kaili Jin Xuanyi Chen Yinghuan Li Xiaofeng Xu Source Type: research
Transcriptional analysis of oxidative and nitrosative stress on oral opportunistic Candida albicans
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):250-256. doi: 10.14715/cmb/2024.70.2.35.ABSTRACTThe yeast Candida albicans is one of the most aggressive opportunistic pathogens in immunocompromised patients. The ability of the yeast to withstand stresses and radicals is of great concern. In the present study, four isolates of C. albicans were taken from patients with oral candidiasis and grown on RPMI for 24 hours at 37°C. Then, they were exposed to various concentrations of oxidative (H2O2) and nitrosative (HNO3) stress for two hours, and gene expression rates were measured through RT-PCR. After initial biofilm formati...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Rezhin Ali Mohammed Karzan Abdulmuhsin Mohammad Source Type: research
Sema3A ameliorates the pathological progression of osteoarthritis by modulating mitochondrial damage in chondrocytes
In conclusion, Sema3A has an important influence on the pathological progression of OS, and molecular therapies targeting to increase Sema3A expression may become a new treatment for OS in the future.PMID:38430015 | DOI:10.14715/cmb/2024.70.2.34 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Zhongkui Guo Yong Qin Yi Li Peifu Tang Source Type: research
Effects of Jerusalem artichoke-enriched diet on water quality, growth performance, feed utilization, proximate body composition, and hematology and biochemical parameters in common carp fingerlings
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):235-243. doi: 10.14715/cmb/2024.70.2.33.ABSTRACTThe purpose of this research was to evaluate the impact of Jerusalem artichoke tubers (Helianthus tuberosus L.), a natural prebiotic, on the growth performance, proximate body composition, feed utilization, hematology, and biochemical parameters in common carp (Cyprinus carpio) fingerlings. Four JA-supplemented diets were formulated at 0.0% (control), 0.5%, 1%, and 2%. Fish were reared for ten weeks in cages placed in concrete ponds. Based on the results, an increase in the levels of JA supplementation led to significant impro...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Samad S Omar Source Type: research
Effects of exosomes derived from platelet-rich plasma on osteogenic differentiation of dental pulp stem cells
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):227-234. doi: 10.14715/cmb/2024.70.2.32.ABSTRACTPlatelet-rich plasma (PRP) can cause osteogenic differentiation of dental pulp stem cells (DPSCs). However, the effect of exosomes derived from PRP (PRP-Exos) on osteogenic differentiation of DPSCs remains unclear. Herein, we evaluated the impact of PRP-Exos on osteogenic differentiation of DPSCs. PRP-Exos were isolated and identified by transmission electron microscopy (TEM) and western blotting (WB). Immunofluorescence staining was performed to evaluate endocytosis of PRP-Exos by DPSCs. Alkaline phosphatase staining, alizari...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Chuzi Mo Zhongjun Liu Yunhe Lin Nu Er Bi Ya A Bu Du Xi Ku Siwei Li Qiao Ruan Chengxia Liu Shuaimei Xu Jun Wen Source Type: research
Changes in biochemical and sperm parameters of rats drinking energy drinks
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):212-216. doi: 10.14715/cmb/2024.70.2.30.ABSTRACTTiger energy drink is used in this research to see the effect on serum lipid profile, liver enzymes, and kidney function, also observing changes in sperm parameters. Sixteen male rats were divided into four groups, each consisting of four rats. The control group was given water and rat feed, while groups 1, 2, and 3 were given water with Tiger energy drink (25%, 50%, and 75%, respectively) for eight weeks. The results showed that the effect of energy drinks on lipid profile decreased cholesterol, TG, and LDL, while there was a...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Sarwar N Jafar Source Type: research
Effects of Leukocyte-rich platelet-rich plasma and Leukocyte-poor platelet-rich plasma on cartilage in a rabbit osteoarthritis model
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):217-226. doi: 10.14715/cmb/2024.70.2.31.ABSTRACTOsteoarthritis is a prevalent chronic disease. One of its primary pathological processes involves the degeneration of articular cartilage. Platelet-rich plasma (PRP) contains cytokines and growth factors that can stimulate the repair and regeneration of articular cartilage tissues. PRP may also slow the progression of osteoarthritis. The purpose of this experiment is to compare the efficacy of Leukocyte poor (LP) - PRP and Leukocyte rich (LR) - PRP in treating rabbit osteoarthritis and to investigate their mechanisms of action...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Kefan Zhang Chenchen Zhang Qiang Ren Dening Wang Li Sun Xin Wang Yaomin Wang Hui Shi Source Type: research
miR-127-5p regulates FAIM2-mediated cell apoptosis and participates in cerebral ischemia-reperfusion injury
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):189-196. doi: 10.14715/cmb/2024.70.2.27.ABSTRACTMechanical thrombectomy (MT) has become an effective re-airway method for cerebral ischemia-reperfusion injury (CI/RI). However, at present, there are few studies on the impact of MT therapy on the prognosis of CI/RI patients at home and abroad. Therefore, this paper aims to analyze the relevant factors affecting the prognosis of CI/RI patients after MT therapy. The main regulatory miRNAs during CI/RI in patients with MT were screened and studied. Serums were obtained from 80 patients (moderate to severe stroke) who underwent ...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Teng Hu Yongzhong Lin Source Type: research
Dynamic changes and clinical value of Sirt6 in acute coronary syndrome (ACS) patients
This study aimed to investigate the role of Sirt6 and inflammatory cytokines in blood samples of patients with ACS. This is a retrospective randomized controlled clinical trial, a total of 30 patients from our hospital are included and divided into following two groups: control group and experimental group, and experimental group consists of 15 patients with ACS and control group consists of 15 patients with non-acute coronary syndrome. Sirt6 protein is detected by western blotting and Sirt6 mRNA is detected by real-time PCR, then inflammatory cytokines such as IL-1β, IL-18, TnI, and CK-MB are measured by ELISA and cytoki...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Gang Tian Chunxiao Zhang Source Type: research
Homocysteine modulates CXCL10/CXCR3 axis activity to induce endothelial dysfunction
In conclusion, our findings illuminated the central role of the CXCL10/CXCR3 axis in mediating Hcy-induced endothelial dysfunction, providing valuable insights for potential therapeutic strategies in managing HHcy-related cardiovascular diseases.PMID:38430022 | DOI:10.14715/cmb/2024.70.2.28 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Yanjie Xu Yingying Xu Zuozong Yu Dingwen He Source Type: research
Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes
This study aimed to elucidate the effect of mitochondria-targeted reactive oxygen species (ROS) blockor SS-31 on hepatic stellate cells (HSC) activation during liver fibrosis. TGF-β1 was employed to induce HSC activation, while MitoSOX Red was utilized to assess the presence of mitochondrial ROS. The mitochondrial membrane potential (MMP) was measured using the JC-1 probe, and the ATP level was determined using a specific kit. The proliferation of HSCs was assessed using CCK-8 and colony formation assays, whereas flow cytometry was employed to detect HSC apoptosis. Fibrotic markers (COL1A1 and α-SMA) and NLRP3 inflammaso...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Li Liu YingFeng Wei NingSheng Xie Hong Cai Ye Lin Source Type: research
