TMCO1 regulates cell proliferation, metastasis and EMT signaling through CALR, promoting ovarian cancer progression and cisplatin resistance
This study aimed to explore the involvement of Transmembrane and coiled-coil domains 1 (TMCO1) in ovarian cancer progression and its regulatory mechanisms in cisplatin resistance. Using the GEPIA database, we analyzed TMCO1 expression in ovarian cancer and normal tissues. In a cohort of 99 ovarian cancer patients, immunohistochemistry and immunofluorescence were employed to assess TMCO1 expression in tumor and adjacent tissues, correlating findings with clinical and pathological characteristics. TMCO1 overexpression and knockout cell models were constructed, and their impact on non-cisplatin-resistant (SK-OV-3) and cisplat...
Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Guangyu Sun Shan Gong Suwei Lan Ying He Yanhua Sun Zhengmao Zhang Source Type: research

Correlation analysis of vaginal flora and immune function Th1/Th2 imbalance in women with high-risk HPV infections in the female reproductive tract
Cell Mol Biol (Noisy-le-grand). 2024 Jan 31;70(1):128-133. doi: 10.14715/cmb/2024.70.1.17.ABSTRACTThe purpose of this study was to analyze the correlation between vaginal flora and immune function Type 1 helper T cells/Type 2 helper T cells imbalance in females having HPV infections at high risk within the female reproductive tract. We selected 150 female patients who visited our hospital for reproductive tract inflammation between March 2019 and March 2021. They were divided into high-risk HPV-positive and high-risk HPV-negative groups according to the results of the HPV tests. Vaginal flora composition, density, diversit...
Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Jingjing Zheng Rongwei Zhao Chunxia Deng Source Type: research

A Study of transcription factor MEF2A gene polymorphisms in patients with coronary artery disease
In conclusion, we identified a much higher incidence of MEF2A in people with coronary artery disease, and MEF2A may play a crucial role in cardiovascular pathophysiology. Patients and controls had considerably different genetics and frequency of alleles.PMID:38372109 | DOI:10.14715/cmb/2024.70.1.11 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Kazhal Muhammad Sulaiman Source Type: research

The effects of dietary organic selenium on growth, body composition and hematological parameters of common Carp (Cyprinus carpio) reared in recirculating aquaculture system
Cell Mol Biol (Noisy-le-grand). 2024 Jan 31;70(1):87-93. doi: 10.14715/cmb/2024.70.1.12.ABSTRACTA feeding trial was conducted to examine the effects of different levels of dietary organic selenium (Se) on the growth, body composition, and hematological indices of common carp. Se element was supplemented to the basal diet at the rates of 0.0, 0.5, 1 and 2 mgkg-1. Fish were randomly stocked at a rate of 25 fish into 500L tanks in the Recirculating Aquaculture System (RAS) system for 10 weeks. Weight gain, final body weight, and specific growth rate were significantly higher (p<0.05) in fish fed 0.5 mgkg-1 followed by 1 an...
Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Ibrahim Abdulrahman Mustafa Samad Sofy Omar Source Type: research

Enhancing the efficiency and functionality of xylanase from Bacillus sp. RTS11: Optimization, purification, characterization, and prospects in kraft pulp bleaching
Cell Mol Biol (Noisy-le-grand). 2024 Jan 31;70(1):67-79. doi: 10.14715/cmb/2024.70.1.10.ABSTRACTBacillus sp. RTS11, a xylanolytic strain, was isolated from the Algerian desert rocks. Genetic analysis revealed a remarkable 98.69% similarity to Bacillus pumilus. We harnessed optimization techniques, including Plackett-Burman screening and Box-Behnken optimization design, to amplify xylanase production and activity. The outcome of these efforts was an optimized medium that yielded an impressive xylanase production titer of 448.89 U, a threefold increase compared to the non-optimized medium (146 U). The Purification of xylanas...
Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Sara Sahnoun Bilal Yahiaoui Aicha Benlounissi Abdenacer Mouffok Barbara Ernst Manawwer Alam Karim Houali Yacine Benguerba Source Type: research