Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells
J Proteome Res. 2024 Apr 22. doi: 10.1021/acs.jproteome.3c00713. Online ahead of print.ABSTRACTAutophagy supervises the proteostasis and survival of B lymphocytic cells. Trk-fused gene (TFG) promotes autophagosome-lysosome flux in murine CH12 B cells, as well as their survival. Hence, quantitative proteomics of CH12tfgKO and WT B cells in combination with lysosomal inhibition should identify proteins that are prone to lysosomal degradation and contribute to autophagy and B cell survival. Lysosome inhibition via NH4Cl unexpectedly reduced a number of proteins but increased a large cluster of translational, ribosomal, and mi...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Tobit D Steinmetz Jana Thomas Lena Reimann Ann-Kathrin Himmelreich Sebastian R Schulz Florian Golombek Kathrin Castiglione Hans-Martin J äck Susanne Brodesser Bettina Warscheid Dirk Mielenz Source Type: research
Modest effect of differential dietary vitamin A intake on the pathogenesis of alcohol-associated liver disease
CONCLUSIONS: Altered vitamin A intake and hepatic vitamin A storage have a minor effect on the pathogenesis of ALD. Thus, given the known link between altered retinoic acid signaling and ALD, future studies that further explore this linkage are warranted.PMID:38649284 | DOI:10.1111/acer.15329 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Afroza Ferdouse Robin D Clugston Source Type: research
Development of natural dye photosensitizers for dye-sensitized solar cells: a review
Environ Sci Pollut Res Int. 2024 Apr 22. doi: 10.1007/s11356-024-33360-4. Online ahead of print.ABSTRACTDye-sensitized solar cell (DSSC) is a photovoltaic device that can be produced from natural source pigments or natural dyes. The selection of natural dyes for DSSC application is currently under research. The utilization of natural dye materials that are easy to obtain, cost-effective, and non-toxic can reduce waste during DSSC fabrication. Natural dyes can be extracted from plants through extraction and chromatography methods. The suitability and viability of utilizing natural dyes as photosensitizers in DSSCs can be pr...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Aripin Triyanto Nora'aini Ali Hasiah Salleh Jan Setiawan Norhafiza I Yatim Source Type: research
CircPRKD3/miR-6783-3p responds to mechanical force to facilitate the osteogenesis of stretched periodontal ligament stem cells
CONCLUSIONS: Our results first suggested that both circPRKD3 and hsa-miR-6783-3p could enhance osteogenesis of stretched PDLSCs. Furthermore, hsa-miR-6783-3p could sponge circPRKD3 to indirectly regulate RUNX2 during the periodontal tissue remodeling process in orthodontic treatment.PMID:38649946 | DOI:10.1186/s13018-024-04727-7 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Jiani Liu Rui Liu Hong Wang Zijie Zhang Jixiao Wang Fulan Wei Source Type: research
Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury
CONCLUSIONS: Our findings show that stepwise combined cell therapy can induce alterations in the microenvironment for effective cell therapy in SCI. The in vitro results suggest that co-culturing hMSC and iMN can synergistically promote induction of MN neurite outgrowth.PMID:38650015 | DOI:10.1186/s13287-024-03714-3 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Jang-Woon Kim Juryun Kim Hyunkyung Mo Heeju Han Yeri Alice Rim Ji Hyeon Ju Source Type: research
The extracts of osteoblast developed from adipose-derived stem cell and its role in osteogenesis
J Orthop Surg Res. 2024 Apr 22;19(1):255. doi: 10.1186/s13018-024-04747-3.ABSTRACTCell-based therapy has become an achievable choice in regenerative medicines, particularly for musculoskeletal disorders. Adipose-derived stem cells (ASCs) are an outstanding resource because of their ability and functions. Nevertheless, the use of cells for treatment comes with difficulties in operation and safety. The immunological barrier is also a major limitation of cell therapy, which can lead to unexpected results. Cell-derived products, such as cell extracts, have gained a lot of attention to overcome these limitations. The goal of th...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Rattanawan Tangporncharoen Atiruj Silathapanasakul Patcharapa Tragoonlugkana Chatchai Pruksapong Tulyapruek Tawonsawatruk Aungkura Supokawej Source Type: research
MicroRNAs predict early complications of autologous hematopoietic stem cell transplantation
Biomark Res. 2024 Apr 23;12(1):42. doi: 10.1186/s40364-024-00585-x.ABSTRACTAutologous hematopoietic stem cell transplantation (AHSCT) remains the most prevalent type of stem cell transplantation. In our study, we investigated the changes in circulating miRNAs in AHSCT recipients and their potential to predict early procedure-related complications. We collected serum samples from 77 patients, including 54 with multiple myeloma, at four key time points: before AHSCT, on the day of transplantation (day 0), and at days + 7 and + 14 post-transplantation. Through serum miRNA-seq analysis, we identified altered expression pattern...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Damian Mikulski Mateusz Nowicki Izabela Dr óżdż Ewelina Perdas Piotr Strza łka Kacper Ko ścielny Ma łgorzata Misiewicz Konrad Stawiski Agnieszka Wierzbowska Wojciech Fendler Source Type: research
DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis
CONCLUSIONS: Given the current ambiguity surrounding the cause of OSF and the limited treatment options available, our study reveals that epithelial cells and their crosstalk with T cells play an important role in the mechanism of OSF and suggests the therapeutic promise of DPSCs.PMID:38650025 | DOI:10.1186/s13287-024-03720-5 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: S Y Wang S J Zhang H F Meng H Q Xu Z X Guo J F Yan J L Gao L N Niu S L Wang K Jiao Source Type: research
Carrageenan maintains the contractile phenotype of vascular smooth muscle cells by increasing macromolecular crowding in vitro
CONCLUSIONS: The in vitro study showed that VSMCs can maintain the contractile phenotype by sensing changes in the crowding of the culture environment, which can be maintained by adding CR.PMID:38650027 | DOI:10.1186/s40001-024-01843-2 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Qing Liu Hong-Jing Jiang Yin-Di Wu Jian-Dong Li Xu-Heng Sun Cong Xiao Jian-Yi Xu Zhan-Yi Lin Source Type: research
Mesenchymal stem cells promote ovarian reconstruction in mice
CONCLUSIONS: The presence of BM-MSCs in the artificial ovary was found to promote the survival of ovarian cells, as well as facilitate follicle formation and development. Since the cells didn't proliferate in the reconstituted ovary, this discovery suggests a potential new and safe method for the application of MSCs in clinical fertility preservation by enhancing the success rate of cryo-thawed ovarian tissues after transplantation.PMID:38650029 | DOI:10.1186/s13287-024-03718-z (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Jiazhao Li Haonan Fan Wei Liu Jing Zhang Yue Xiao Yue Peng Weijie Yang Wenwen Liu Yuanlin He Lianju Qin Xiang Ma Jing Li Source Type: research
Effector Function Characteristics of Exhausted CD8+ T-cell in Microsatellite Stable and Unstable Gastric Cancer
CONCLUSION: Our study reveals novel finding indicating that IFN-γ signaling pathway is retained in Tex and pTex of MSI-H gastric cancer, offering a comprehensive perspective for future investigations into immunotherapy for gastric cancer.PMID:38637967 | DOI:10.4143/crt.2024.317 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Dong-Seok Han Yoonjin Kwak Seungho Lee Soo Kyung Nam Seong-Ho Kong Do Joong Park Hyuk-Joon Lee Nak-Jung Kwon Hye Seung Lee Han-Kwang Yang Source Type: research
Outcomes of Total Hip Arthroplasty Performed for HIV-Associated Osteonecrosis in China: A Retrospective Cohort Study
CONCLUSION: THA is safe and effective in Chinese AIDS patients with ONFH. However, optimal treatment has limited efficacy in AIDS patients undergoing THA for ONFH. The reconsideration and evaluation of the predictive value of CD4+ T lymphocytes for postoperative complications in joint replacement procedures is warranted.PMID:38638043 | DOI:10.2174/011570162X302889240408033958 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Kangpeng Li Rui Ma Rugang Zhao Qiang Zhang Source Type: research
Knocking down GRAMD1C expression reduces 6-OHDA-induced apoptosis in PC12 cells
CONCLUSION: GRAMD1C is upregulated in PD, and may affect the PD process through the apoptotic pathway.PMID:38638451 | PMC:PMC11023001 | DOI:10.1093/toxres/tfae051 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Hui He Bo Zhang Xiang Wang Lulu Chen Source Type: research
Bilateral Optic Neuropathy Secondary to Intravenous Carboplatin Therapy
CONCLUSION: Our findings in this case justify monitoring of patients during their course of intravenous carboplatin therapy.PMID:38638619 | PMC:PMC11022029 | DOI:10.18502/jovr.v19i1.15448 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Arash Maleki Mollie K Lagrew Elizabeth D Slaney None Md Source Type: research
Fluorescein versus Indocyanine Green Angiography Guided Half-Dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy
CONCLUSION: FA-guided and ICG-guided half-dose PDT may have similar efficacy for the treatment of chronic CSC.PMID:38638623 | PMC:PMC11022023 | DOI:10.18502/jovr.v19i1.15420 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Farzan Moodi Masood Naseripour Amin Zand Reza Mirshahi Vihan Moodi Sayyed Amirpooya Alemzadeh Khalil Ghasemi Falavarjani Source Type: research
