Metabolic Syndrome and Cardiac Vessel Remodeling Associated with Vessel Rarefaction: A Possible Underlying Mechanism May Result from a Poor Angiogenic Response to Altered VEGF Signaling Pathways
J Vasc Res. 2024 Apr 12:1-9. doi: 10.1159/000538361. Online ahead of print.ABSTRACTBACKGROUND: Elevated mortality rates in patients with metabolic syndrome (MetS) are partly due to adverse remodeling of multiple organs, which may lead to cardiovascular disease, nonalcoholic fatty liver disease, kidney failure, or other conditions. MetS symptoms, such as obesity, hypertension, hyperglycemia, dyslipidemia, associated with insulin and leptin resistance, are recognized as major cardiovascular risk factors that adversely affect the heart.SUMMARY: Pathological cardiac remodeling is accompanied by endothelial cell dysfunction whi...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Krzysztof Bartkowiak Mateusz Bartkowiak Ewa Jankowska-Steifer Anna Ratajska Marek Kujawa Olga Anio łek Justyna Niderla-Bieli ńska Source Type: research
Redox signaling in cell fate: Beyond damage
Biochim Biophys Acta Mol Cell Res. 2024 Apr 12:119722. doi: 10.1016/j.bbamcr.2024.119722. Online ahead of print.ABSTRACTThis review explores the nuanced role of reactive oxygen species (ROS) in cell fate, challenging the traditional view that equates ROS with cellular damage. Through significant technological advancements in detecting localized redox states and identifying oxidized cysteines, a paradigm shift has emerged: from ROS as merely damaging agents to crucial players in redox signaling. We delve into the intricacies of redox mechanisms, which, although confined, exert profound influences on cellular physiological r...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Felix Lamontagne Cynthia Paz Trejo Natalia Zamorano Cuervo Nathalie Grandvaux Source Type: research
Urolithin a inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
CONCLUSION: Our study elucidated the anti-breast cancer effect of UA from the perspective of tumor-associated macrophages. Specifically, TFEB is a crucial downstream target in macrophages.PMID:38615740 | DOI:10.1016/j.jare.2024.04.010 (Source: Cell Research)
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Bowen Zheng Yuying Wang Baian Zhou Fengyuan Qian Diya Liu Danrong Ye Xiqian Zhou Lin Fang Source Type: research
Tanshinone IIA destabilizes SLC7A11 by regulating PIAS4-mediated SUMOylation of SLC7A11 through KDM1A, and promotes ferroptosis in breast cancer
CONCLUSION: Tan IIA promoted ferroptosis and inhibited tumor growth and metastasis via suppressing KDM1A/PIAS4/SLC7A11 axis.PMID:38615741 | DOI:10.1016/j.jare.2024.04.009 (Source: Cell Research)
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Na Luo KeJing Zhang Xin Li Yu Hu Lei Guo Source Type: research
Health risk assessment of heavy metal(loid)s in road dust via dermal exposure pathway from a low latitude plateau provincial capital city: The importance of toxicological verification
In this study, the road dust samples were harvested from a typical low-latitude plateau provincial capital city Kunming, Southwest China. The total concentration and dermal bioaccessibility of heavy metal(loid)s in road dust were determined, and their health risks and cytotoxicity on human skin keratinocytes were also assessed. The average concentrations of As (28.5 mg/kg), Cd (2.65 mg/kg), Mn (671 mg/kg), and Zn (511 mg/kg) exceeded the soil background values. Arsenic had the highest bioaccessibility after 2 h (3.79%), 8 h (4.24%), and 24 h (16.6%) extraction. Although soil assessment methods showed no health risk in the ...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Jingya Li Daolei Cui Ziyue Yang Jiaoyang Ma Jianjun Liu Yingxin Yu Xianfeng Huang Ping Xiang Source Type: research
Possible Retinotoxicity of Long-term Vardenafil Treatment
Exp Eye Res. 2024 Apr 12:109890. doi: 10.1016/j.exer.2024.109890. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term varde...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Klaudia Szab ó Bulcs ú Dékány Anna Énzsöly Rozina Ida Hajd ú Lenke Korn élia Laurik-Feuerstein Arnold Szab ó Tam ás Radovits Csaba M átyás Attila Ol áh Kriszti án András Kovács Ágoston Szél G ábor Márk Somfai Ákos Lukáts Source Type: research
Metabolic Regulation of the Th17/Treg Balance in Inflammatory Bowel Disease
Pharmacol Res. 2024 Apr 12:107184. doi: 10.1016/j.phrs.2024.107184. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is pivotal in the pathogenesis and progression of IBD. This review summarizes the pivotal role of Th17/Treg equilibrium in maintaining intestinal homeostasis, elucidating how its dysregulation contributes to the development and exacerbation of IBD. It comprehensively synthesizes the c...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Shunfen Zhang Ruqing Zhong Shanlong Tang Liang Chen Hongfu Zhang Source Type: research
12,13-diHOME attenuates high glucose-induced calcification of vascular smooth muscle cells through repressing CPT1A-mediated HMGB1 succinylation
This study enrolled 159 elderly patients with type 2 diabetes and divided them into three groups, T1, T2 and T3, according to brachial-ankle pulse wave velocity(BaPWV). There were statistically significant differences in the waist circumference, waist hip ratio, systolic blood pressure, 12,13-diHOME (a lipokin) concentration among T1, T2 and T3. 12,13-diHOME levels were positively correlated to high density lipoprotein cholesterol and total cholesterol, but negatively correlated to with waist circumference, waist hip ratio, systolic blood pressure and baPWV. Studies in vitro showed that 12,13-diHOME effectively inhibits ca...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Huahua Li Lingling Zou Jin Zheng Tao Yang Source Type: research
Tissue-specific inflammation and insulin sensitivity in subjects with obesity
Diabetes Res Clin Pract. 2024 Apr 12:111663. doi: 10.1016/j.diabres.2024.111663. Online ahead of print.ABSTRACTObesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationship. The first cohort consists of six women with normal weight and twenty with obesity. In women with obesity, we found an upregulation of inflammatory markers in subcutaneous and visceral adipose tissue, isolated AT macrophages, and the liver, but no linear correlation with tissu...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: S M Oussaada M Kilicarslan B A de Weijer P W Gilijamse A Şekercan S Virtue I M C Janssen A van de Laar A Demirkiran B A van Wagensveld A P J Houdijk A Jongejan P D Moerland J Verheij T B Geijtenbeek V W Bloks M C de Goffau J A Romijn M Nieuwdorp A Vidal- Source Type: research
Influence of a mesial cantilever on stress, strain, and axial force in fixed partial dentures with a distally tilted implant in the atrophic posterior maxilla
CONCLUSIONS: Mesial cantilever usage had minimal effect on stress or strain distribution in FPD implants, abutments, or prostheses. However, it helped resist screw loosening. The distal screw access hole was preferably positioned close to the prosthetic end.PMID:38616127 | DOI:10.2186/jpr.JPR_D_23_00218 (Source: Cell Research)
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Xiaohui Fan Li Chen Qiuren Chen Feng Wang Yiqun Wu Yuanyuan Sun Source Type: research
Resveratrol-Loaded Polydimethylsiloxane-Silica Hybrid Materials: Synthesis, Characterization, and Antitumoral Activity
Polymers (Basel). 2024 Mar 22;16(7):879. doi: 10.3390/polym16070879.ABSTRACTIn this work, hybrid materials within the polydimethylsiloxane-silica (PDMS-SiO2) system, synthesized via the sol-gel method, were developed and characterized for their potential to incorporate and release the bioactive compound resveratrol (RES). RES was incorporated into the materials with a high loading efficiency (>75%) using the rotary evaporator technique. This incorporation induced the amorphization of RES, resulting in enhanced solubility and in vitro release when compared to the free polyphenolic compound. The release profiles displayed...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Sofia Viegas Diogo Marinheiro Ver ónica Bastos Ana L Daniel-da-Silva Ricardo Vieira Helena Oliveira Jos é Carlos Almeida B árbara J M L Ferreira Source Type: research
Transient Receptor Potential Ankyrin 1 Ion Channel Is Expressed in Osteosarcoma and Its Activation Reduces Viability
Int J Mol Sci. 2024 Mar 28;25(7):3760. doi: 10.3390/ijms25073760.ABSTRACTOsteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are non-selective cation channels that have been of great interest in cancer, as their expression is increased in some malignancies. In our study we aim to characterize the expression and functionality of the TRPA1 and TRPV1 channels in human and mouse osteosarcoma tissues and in a mouse cell line. TRPA1/Trpa1 and TRPV1/Trpv1 mRNA expressions were demonstrated by PCR ...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Lina Hudhud Katalin Rozmer Ang éla Kecskés Krisztina Poh óczky No émi Bencze Krisztina Buz ás Éva Szőke Zsuzsanna Helyes Source Type: research
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing
Pigment Cell Melanoma Res. 2024 Apr 13. doi: 10.1111/pcmr.13169. Online ahead of print.ABSTRACTMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, ...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Joseph W Palmer Nilesh Kumar Luye An Andrew C White M Shahid Mukhtar Melissa L Harris Source Type: research
Clinical Value of Human Endogenous Retrovirus-H Long Terminal Repeat Associating 2 (HHLA2) in Small Cell Lung Cancer
Conclusion: The new immune molecule HHLA2 may be an ideal clinical biomarker for predicting SCLC progression and could serve as a new immunotherapy target in SCLC.PMID:38613340 | PMC:PMC11015749 | DOI:10.1177/15330338241240683 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Xiuqin Zhang Yan Qin Xu Chen Mengrui Xiong Song Shu Source Type: research
Predictive Value of NLR and PLR in Driver-Gene-Negative Advanced Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors: A Single Institutional Cohort Study
CONCLUSION: Low baseline NLR and PLR levels are significantly associated with better response in advanced NSCLC patients treated with PD-1/PD-L1 inhibitors, which may be indicators to predict the efficacy of immunotherapy in advanced NSCLC with driver-gene-negative.PMID:38613344 | PMC:PMC11015757 | DOI:10.1177/15330338241246651 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Qi Yuan Chunhua Xu Wei Wang Qian Zhang Source Type: research
