Contribution of tumour and immune cells to PD-L1 expression as a predictive biomarker in metastatic triple-negative breast cancer: exploratory analysis from KEYNOTE-119
J Pathol Clin Res. 2024 May;10(3):e12371. doi: 10.1002/2056-4538.12371.ABSTRACTThe efficacy of pembrolizumab monotherapy versus chemotherapy increased with increasing programmed death ligand 1 (PD-L1) expression, as quantified by combined positive score (CPS; PD-L1 expression on both tumour cells and immune cells) in patients with previously treated metastatic triple-negative breast cancer (mTNBC) in the phase 3 KEYNOTE-119 study. This exploratory analysis was conducted to determine whether the expression of PD-L1 on tumour cells contributes to the predictive value of PD-L1 CPS in mTNBC. PD-L1 expression in tumour samples ...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Javier Cortes Eric P Winer Oleg Lipatov Seock-Ah Im Anthony Gon çalves Eva Mu ñoz-Couselo Keun Seok Lee Peter Schmid Kenji Tamura Laura Testa Isabell Witzel Shoichiro Ohtani Stephanie Hund Karina Kulangara Vassiliki Karantza Jaime A Mejia Junshui Ma Pet Source Type: research
Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction
Biomater Res. 2024 Apr 15;28:0016. doi: 10.34133/bmr.0016. eCollection 2024.ABSTRACTTissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models and in drug discovery and screening. Indeed, several studies have shown that organoids are an important strategy for achieving tissue repair and biofunction reconstruction. In contrast to established stem cell therapies, organoids have high clinical relevance. However, conventional approaches have limited the application of organoids in clinical regenerative medicine. Engineered organoids might ha...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Hairong Jin Zengqi Xue Jinnv Liu Binbin Ma Jianfeng Yang Lanjie Lei Source Type: research
Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration
J Immunol Res. 2024 Apr 8;2024:7827246. doi: 10.1155/2024/7827246. eCollection 2024.ABSTRACTDendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor microenvironment, and the need for effective combination therapies. A further limitation in DC-based immunotherapy is the low population of migratory DC (around 5%-10%) that migrate to ly...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Min-Seon Song Ji-Hee Nam Kyung-Eun Noh Dae-Seog Lim Source Type: research
Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma
Leuk Res Rep. 2023 Nov 7;21:100394. doi: 10.1016/j.lrr.2023.100394. eCollection 2024.ABSTRACTHemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Mirza Rameez Samar Daania Shoaib Nida E Zehra Munira Moosajee Source Type: research
Translational Research and Health Equity: Gene Therapies for Sickle Cell Disease as a Case Study
Ethics Hum Res. 2024 May-Jun;46(3):34-39. doi: 10.1002/eahr.500211.ABSTRACTIn August of 2023, the National Academies of Science, Engineering, and Medicine published a timely report titled "Toward Equitable Innovation in Health and Medicine: A Framework." Here, we review some of the key contributions of the report, focusing on two dimensions of equity: input equity and deployment equity. We then use the example of new gene therapies to treat sickle cell disease (SCD) as a case study of input and deployment equity in translational research. The SCD case study illustrates the need for a kind of translational bioethics with de...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Mary A Majumder Titilope Fasipe Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Electroacupuncture Inhibits Neural Ferroptosis in Rat Model of Traumatic Brain Injury via Activating System Xc-/GSH/GPX4 Axis
CONCLUSIONS: EA inhibits neuronal ferroptosis by up-regulated xCT expression and by activating System Xc-/GSH/GPX4 axis after TBI, confirming the relevant theories regarding the EA effect in treating TBI and providing theoretical support for clinical practice.PMID:38629369 | DOI:10.2174/0115672026297775240405073502 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Na Li Ruihui Wang Xia Ai Jie Guo Yuwang Bai Xinrong Guo Rongchao Zhang Xu Du Jingxuan Chen Hua Li Source Type: research
Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research
Extranodal Rosai-Dorfman disease manifesting as Sj ögren's syndrome combined with panuveitis and hypertrophic pachymeningitis: a case report and review of literature
We present the case of a 28-year-old woman who presented with recurrent blurred vision in her right eye for 3 months. She developed blindness and atrophy in her left eye a decade prior to presentation. She subsequently developed headache, fever, and impaired mental status. Cranial magnetic resonance imaging indicated hypertrophic pachymeningitis (HP), and 18F-fluoro-2-deoxy-2-d-glucose (FDG) positron emission tomography/computed tomography revealed significant FDG uptake in the left dura mater. Autoimmune testing revealed elevated anti-nuclear, anti-SS-A, and anti-SS-B antibody levels. Incisional biopsy of the atrophic eye...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Jing Xu Meihua Huang Binsong Dong Min Jian Jinyu Chen Naiyuan Zhang Chunlian Ou Yongming Wu Dongmei Wang Source Type: research
A new resorcylic acid lactone from the endophytic fungus < em > Chaetosphaeronema sp < /em >
J Asian Nat Prod Res. 2024 Apr 17:1-8. doi: 10.1080/10286020.2024.2335254. Online ahead of print.ABSTRACTA new 14-membered resorcylic acid lactone (RAL14), chaetolactone A (1), along with three known ones (2-4), was obtained from the fermentation of the soil-derived fungus Chaetosphaeronema sp. SSJZ001. Their structures were established based on extensive spectroscopic data analyses (UV, IR, HRESIMS, 1D, and 2D NMR),13C NMR chemical shifts calculations coupled with the DP4+ probability method, theoretical calculations of ECD spectra, as well as X-ray diffraction analysis. All compounds were evaluated for their cytotoxic ef...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Min Wang Gui-Yang Xia Yong-Xin Liang Huan Xia Peng-Cheng Lin Sheng Lin Source Type: research
Morphological heterogeneity of neurons in the human central amygdaloid nucleus
J Neurosci Res. 2024 Apr;102(4):e25319. doi: 10.1002/jnr.25319.ABSTRACTThe central amygdaloid nucleus (CeA) has an ancient phylogenetic development and functions relevant for animal survival. Local cells receive intrinsic amygdaloidal information that codes emotional stimuli of fear, integrate them, and send cortical and subcortical output projections that prompt rapid visceral and social behavior responses. We aimed to describe the morphology of the neurons that compose the human CeA (N = 8 adult men). Cells within CeA coronal borders were identified using the thionine staining and were further analyzed using the "single-...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Carlos E V ásquez K étlyn T Knak Guerra Josu é Renner Alberto A Rasia-Filho Source Type: research
Maintenance pembrolizumab therapy in patients with metastatic HER2-negative breast cancer with prior response to chemotherapy
CONCLUSIONS: Pembrolizumab monotherapy achieved durable treatment responses. Patients with a high baseline T-cell clonality had prolonged disease control with pembrolizumab.PMID:38629963 | DOI:10.1158/1078-0432.CCR-23-2947 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Toshiaki Iwase Evan N Cohen Hui Gao Angela Alexander Megumi Kai Vivian Chiv Xiaoping Wang Savitri Krishnamurthy Diane Liu Yu Shen Kumiko Kida Alexandre Reuben Rachel Layman David Ramirez Debu Tripathy Stacy L Moulder Clinton Yam Vicente Valero Bora Lim Ja Source Type: research
Hydroxyapatite nano-pillars on TI-6Al-4V: Enhancements in cell spreading and proliferation during cell/surface integration
J Biomed Mater Res A. 2024 Apr 17. doi: 10.1002/jbm.a.37726. Online ahead of print.ABSTRACTDespite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti-6Al-4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of biomedical devices into the human body. This paper presents a novel, easy and reproducible method of nanoscale and nanostructured hydroxyapatite (HA) coatings on Ti-6Al-4V. The resulting nanoscale coatings/nanostructures are characterized using a combination of Raman spectroscopy, scann...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Sarah Akua Osafo Precious Osayamen Etinosa John David Obayemi Ali Azeko Salifu Tabiri Asumadu Desmond Klenam Benjamin Agyei-Tuffour David Dodoo-Arhin Abu Yaya Winston Oluwole Soboyejo Source Type: research
Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway
CONCLUSION: EFNA3 could be a valuable prognostic factor in CM.PMID:38630320 | DOI:10.1007/s00432-024-05711-8 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Ningning Yao Qingyue Ma Wendan Yi Yuanzhang Zhu Yichong Liu Xiaodi Gao Qian Zhang Wenjuan Luo Source Type: research
