A new resorcylic acid lactone from the endophytic fungus < em > Chaetosphaeronema sp < /em >

J Asian Nat Prod Res. 2024 Apr 17:1-8. doi: 10.1080/10286020.2024.2335254. Online ahead of print.ABSTRACTA new 14-membered resorcylic acid lactone (RAL14), chaetolactone A (1), along with three known ones (2-4), was obtained from the fermentation of the soil-derived fungus Chaetosphaeronema sp. SSJZ001. Their structures were established based on extensive spectroscopic data analyses (UV, IR, HRESIMS, 1D, and 2D NMR),13C NMR chemical shifts calculations coupled with the DP4+ probability method, theoretical calculations of ECD spectra, as well as X-ray diffraction analysis. All compounds were evaluated for their cytotoxic effects against A549, HO-8910, and MCF-7 cell lines.PMID:38629616 | DOI:10.1080/10286020.2024.2335254

Source: Cell Research - April 17, 2024 Category: Cytology Authors: Min Wang Gui-Yang Xia Yong-Xin Liang Huan Xia Peng-Cheng Lin Sheng Lin Source Type: research