Modified Lichong decoction intervenes in colorectal cancer by modulating the intestinal flora and the Wnt/ β-catenin signaling pathway
CONCLUSION: MLCD mitigated the abnormal growth of intestinal epithelial cells and promoted apoptosis, thereby inhibiting the progression of CRC. This inhibition was accomplished by modifying the intestinal microbiota and disrupting the Wnt/β-catenin pathway and the EMT. Therefore, MLCD could serve as a potential component of TCM prescriptions for CRC treatment.PMID:38710918 | DOI:10.1007/s00432-024-05763-w (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Longhui Liu Mengmeng Zhao Xiaomeng Lang Sujie Jia Xin Kang Yue Liu Jianping Liu Source Type: research
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism
CONCLUSIONS: In summary, through integrated multiomics analysis, including both in vivo and in vitro experiments, this study demonstrated that mannose primarily exerts its anti-catabolic effects on IVDD through the TXNIP-glutamine axis. These findings provide strong evidence supporting the potential of the use of mannose in clinical applications for alleviating IVDD. Compared to existing clinically invasive or pain-relieving therapies for IVDD, the oral administration of mannose has characteristics that are more advantageous for clinical IVDD treatment.PMID:38711073 | PMC:PMC11071241 | DOI:10.1186/s40779-024-00529-4 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Zheng-Lin Dong Xin Jiao Zeng-Guang Wang Kai Yuan Yi-Qi Yang Yao Wang Yun-Tao Li Tian-Chang Wang Tian-You Kan Jian Wang Hai-Rong Tao Source Type: research
DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway
CONCLUSIONS: Our study illustrates that DCAF1 plays a crucial role in HCC development and the DCAF1/PARD3/Akt axis presents a potentially effective therapeutic strategy for HCC.PMID:38711082 | DOI:10.1186/s13046-024-03055-2 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Jinyao Zhang Yuze Shi Ke Ding Weiwei Yu Jianbo He Beicheng Sun Source Type: research
Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells
CONCLUSIONS: This study identifies a potent and selective inhibitor of CtBP1/BARS active in cellular and melanoma animal models revealing new opportunities to study the role of CtBP1/BARS in tumor biology and to develop novel melanoma treatments.PMID:38711119 | DOI:10.1186/s13046-024-03044-5 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Angela Filograna Stefano De Tito Matteo Lo Monte Rosario Oliva Francesca Bruzzese Maria Serena Roca Antonella Zannetti Adelaide Greco Daniela Spano Inmaculada Ayala Assunta Liberti Luigi Petraccone Nina Dathan Giuliana Catara Laura Schembri Antonino Colan Source Type: research
Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters
This study could stimulate further studies, optimization and potential applications of IgY antibodies as therapeutics and prophylactics for human and animals.PMID:38711133 | DOI:10.1186/s40659-024-00508-y (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Binan Zhao Haoran Peng Yanjing Zhang Jie Zhang Desheng Kong Sai Cao Yan Li Dan Yang Chuanwen Sun Xinyi Pu Ping Zhao Yan Xu Kai Zhao Liangzhi Xie Source Type: research
Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies
This article reviews the role of natural products in IBD treatment by focusing on targeting PCD pathways, opening new avenues for clinical IBD management.PMID:38706097 | DOI:10.1002/ptr.8216 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Mengjie Wang Zhiyuan Wang Zhichao Li Yuan Qu Jiting Zhao Lei Wang Xinpeng Zhou Ziqi Xu Di Zhang Ping Jiang Bing Fan Ying Liu Source Type: research
USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1
Conclusion: Our findings indicated that USP39 knockdown may inhibit HNSCC viability and migration by suppressing STAT1 expression. The results of this study suggest that USP39 may be a potential new target for HNSCC clinical therapy or a new biomarker for HNSCC.PMID:38706215 | DOI:10.1177/15330338241250298 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Yu Hu Yang Wang Wenrui Hu Chenrui Hu Bin Wang Congli Liu Anqi Deng Bing Shen Kaile Wu Yehai Liu Source Type: research
Lamiales epidermal dynamics: Unveiling antimicrobial resilience in a structural symphony
Microsc Res Tech. 2024 May 5. doi: 10.1002/jemt.24588. Online ahead of print.ABSTRACTThis research on Lamiales epidermal anatomy not only provides in-depth understanding of their structural traits but also highlights the significance of uncovering the inherent antimicrobial resilience embedded within these plants. Such insights hold promise for advancing natural product-based approaches in medicine, potentially contributing to the development of novel antimicrobial agents inspired by Lamiales unique biological defense mechanisms. Scanning microscopic tools were utilized to conduct foliar epidermal anatomy of nine species t...
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Reem M Aljowaie Gokhan Zengin Nidal Jaradat Afat O Mammadova Abul Kalam Azad Ozal Beylerli Aferin Beilerli Ferzane Valioglu Jonida Biturku Ifrah Kiren Source Type: research
A Single-Arm Multi-Center Phase II Clinical Trial of Cadonilimab (anti-PD-1/CTLA-4) in Combination with or without Conventional Second-Line Treatment for Patients with Extensive Stage Small Cell Lung Cancer
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241249690. doi: 10.1177/15330338241249690.ABSTRACTBACKGROUND: Cadonilimab (AK104) is a bispecific IgG-single-chain Fv fragment (ScFv) antibody that binds to PD-1 and CTLA-4. Cadonilimab has shown encouraging anti-tumour activity and a favourable safety profile in several tumour types. In second-line treatment, there is no defined standard of care for patients with extensive-stage small-cell lung cancer (ES-SCLC). Cadonilimab is expected to show substantial clinical efficacy.OBJECTIVE: To assess the antitumor activity and safety of cadonilimab monotherapy or combination with...
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Can Chen Minjun Chen Yuju Bai Yajun Li Jie Peng Biao Yao Jiangping Feng Jian-Guo Zhou Hu Ma Source Type: research
piR-1919609 Is an Ideal Potential Target for Reversing Platinum Resistance in Ovarian Cancer
CONCLUSION: In summary, we showed that piR-1919609 is involved in the regulation of drug resistance in ovarian cancer cells and might be an ideal potential target for reversing platinum resistance in ovarian cancer.PMID:38706262 | DOI:10.1177/15330338241249692 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Ying Yan Dan Tian Bingbing Zhao Zhuang Li Zhijiong Huang Kuina Li Xiaoqi Chen Lu Zhou Yanying Feng Zhijun Yang Source Type: research
Impact of parity number, milk production and somatic cell count on the reproduction of Holstein cows - ERRATUM
J Dairy Res. 2024 May 6:1. doi: 10.1017/S0022029924000177. Online ahead of print.NO ABSTRACTPMID:38706343 | DOI:10.1017/S0022029924000177 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Bianca Let ícia Barbosa Victor Breno Pedrosa Luciana da Silva Leal Karolewski Caio C ésar de Godoi Adriana de Souza Martins Source Type: research
Exploring the antimitotic, thrombolytic, and cytotoxic properties of lasiosiphon glaucus or gnidia glauca (fresen.) gilg leaf alkaloid extract: insights from experimental and in silico investigations
Nat Prod Res. 2024 May 6:1-5. doi: 10.1080/14786419.2024.2349256. Online ahead of print.ABSTRACTPlant alkaloids are nitrogen containing secondary metabolites that have wide range of biological properties including anticancer activity. 'Lasiosiphon glaucus', or 'Gnidia glauca (Fresen.) Gilg,' known for its biological properties, requires exploration to evaluate cytotoxic and anticancer effects. The present study is aimed to evaluate L. glaucus leaf alkaloid extract (LgLAE) for antimitotic, thrombolytic, and cytotoxic properties. LgLAE demonstrated comparable antimitotic efficacy to methotrexate in Allium cepa root meristema...
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Poorna Vivek Valleti Vadlapudi Kumar Pradeep Kumar Ramayanam Ranjitha Gopalappa Poornima Vijendra Dittekoppa Anuradha Cm Source Type: research
Anti-leukemia effects of ginsenoside monomer: A narrative review of pharmacodynamics study
CONCLUSION: This review shows that ginsenoside derivatives can potentially suppress the growth of leukemia cells via various pathways and can be applied as a new natural medicine for future clinical research.PMID:38706463 | PMC:PMC11066596 | DOI:10.1016/j.curtheres.2024.100739 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Seyyed Mohammad Matin Alavi Dana Mohammadreza Meghdadi Saeed Khayat Kakhki Reza Khademi Source Type: research
Discovering genetic determinants for cell-to-cell adhesion in two prevalent conjugative lactococcal plasmids
Curr Res Microb Sci. 2024 Apr 23;6:100239. doi: 10.1016/j.crmicr.2024.100239. eCollection 2024.ABSTRACTPlasmids pNP40 and pUC11B encode two prevalent yet divergent conjugation systems, which have been characterized in detail recently. Here, we report the elucidation of the putative adhesins of the pNP40 and pUC11B conjugation systems, encoded by traAd and trsAd, respectively. Despite their significant sequence divergence, TraAd and TrsAd represent the most conserved component between the pNP40- and the pUC11B-encoded conjugation systems and share similar peptidoglycan-hydrolase domains. Protein structure prediction using A...
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Guillermo Ortiz Charneco Philip Kelleher Andrius Buivydas Paul P de Waal Irma M H van Rijswijck No ël N M E van Peij Christian Cambillau Jennifer Mahony Douwe Van Sinderen Source Type: research
Banana MabHLH28 positively regulates the expression of softening-related genes to mediate fruit ripening independently or via cooperating with MaWRKY49/111
Hortic Res. 2024 Feb 23;11(4):uhae053. doi: 10.1093/hr/uhae053. eCollection 2024 Apr.ABSTRACTTexture softening is a physiological indicator of fruit ripening, which eventually contributes to fruit quality and the consumer's acceptance. Despite great progress having been made in identification of the genes related to fruit softening, the upstream transcriptional regulatory pathways of these softening-related genes are not fully elucidated. Here, a novel bHLH gene, designated as MabHLH28, was identified because of its significant upregulation in banana fruit ripening. DAP-Seq analysis revealed that MabHLH28 bound to the core...
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Chaojie Wu Danling Cai Jun Li Zengxiang Lin Wei Wei Wei Shan Jianye Chen Wangjin Lu Xinguo Su Jianfei Kuang Source Type: research
