D-mannose alleviates intervertebral disc degeneration through glutamine metabolism

CONCLUSIONS: In summary, through integrated multiomics analysis, including both in vivo and in vitro experiments, this study demonstrated that mannose primarily exerts its anti-catabolic effects on IVDD through the TXNIP-glutamine axis. These findings provide strong evidence supporting the potential of the use of mannose in clinical applications for alleviating IVDD. Compared to existing clinically invasive or pain-relieving therapies for IVDD, the oral administration of mannose has characteristics that are more advantageous for clinical IVDD treatment.PMID:38711073 | PMC:PMC11071241 | DOI:10.1186/s40779-024-00529-4

Source: Cell Research - May 6, 2024 Category: Cytology Authors: Zheng-Lin Dong Xin Jiao Zeng-Guang Wang Kai Yuan Yi-Qi Yang Yao Wang Yun-Tao Li Tian-Chang Wang Tian-You Kan Jian Wang Hai-Rong Tao Source Type: research