A Case of Exfoliative Vesiculobullous Prurigo Pigmentosa Cured by Doxycycline and Topical Tacrolimus
In conclusion, this was a case of exfoliative vesiculobullous prurigo pigmentosa in an adolescent man successfully treated with doxycycline and topical tacrolimus as an effective and safe treatment option.Case Rep Dermatol 2021;13:474 –480 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 23, 2021 Category: Dermatology Source Type: research
Ichthyosis Prematurity Syndrome: A Rare Form but Easily Recognizable Ichthyosis
Ichthyosis prematurity syndrome is a rare autosomal recessive genodermatosis that is associated with mutations in theSLC27A4 gene. Its onset occurs in early childhood and presents with the clinical triad of premature birth, thick caseous desquamating epidermis, and neonatal asphyxia. Here, we describe a prematurely born baby patient (33 weeks of gestation) with a homozygous variant at the initiation codon site (c.1 A#x3e;G,p.Met1Val) in theSLC27A4 gene to raise awareness of this rare syndrome despite its distinctive features as we believe it is still underdiagnosed.Case Rep Dermatol 2021;13:470 –473 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 21, 2021 Category: Dermatology Source Type: research
A Case of Systemic Lupus Erythematosus with Cutaneous Leukocytoclastic Vasculitis Mimicking Bullous SLE
We describe an unusual case in which a patient with SLE developed extensive bullae on her lower extremities. Histologically, the bullous lesions were suggestive of leukocytoclastic vasculitis with deposition of C3 within blood vessel walls. Immunoblot analyses and enzyme-linked immunosorbent assays were negative for anti-type VII collagen antibodies. We initially considered bullous SLE, but eventually made a diagnosis of secondary vasculitis in SLE. The oral prednisolone dose was increased, and the vesiculobullous lesions resolved. The clinical presentations of cutaneous vasculitis in SLE include palpable purpura, petechia...
Source: Case Reports in Dermatology - September 20, 2021 Category: Dermatology Source Type: research
Off-Label 9-Valent Human Papillomavirus Vaccination for Actinic Keratosis: A Case Series
Conclusion: This case series introduces the possibility that 9-valent HPV vaccination in combination with conventional treatments may be used as a therapeutic strategy for AK.Case Rep Dermatol 2021;13:457 –463 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 15, 2021 Category: Dermatology Source Type: research
Raynaud ’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander?
Herein, we report a case of a new-onset Raynaud ’s phenomenon (RP), which occurred in an otherwise healthy 31-year-old Caucasian woman, who lacked any known risk factors and associations with possible causes for secondary RP. However, 2 weeks prior to the development of RP, the patient had received her first injection of the COVID-19 vaccine co ntaining ChAdOx1-SARS-COV-2. The patient presented with well-demarcated, white-pale, cold areas involving the middle fingers of both hands and the ring finger of the right hand, which were triggered by exposure to cold environment and accompanied by a sensation of numbness. Infrar...
Source: Case Reports in Dermatology - September 15, 2021 Category: Dermatology Source Type: research
First Report of Erythema Multiforme Minor Caused by Raloxifene Hydrochloride
In conclusion, raloxifene can cause EM minor in rare cases.Case Rep Dermatol 2021;13:445 –449 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 13, 2021 Category: Dermatology Source Type: research
Reticular Erythematous Mucinosis: Exclusive Involvement of the Axillary Region
We report a case of reticular erythematous mucinosis with exclusive involvement of the axillary region.Case Rep Dermatol 2021;13:441 –444 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 9, 2021 Category: Dermatology Source Type: research
A Case of α-Gal-Unrelated Red Meat-Induced Urticaria Treated by Omalizumab
A 70-year-old healthy woman was referred to our hospital for chronic urticaria. She did not have a history of allergy, asthma, and rhinitis. She was initially diagnosed with α-gal-related urticaria based on an episode of delayed-type urticaria after eating red meat. The results of the intracutaneous allergen test for beef and pork were negative. Fluorenzyme immunoassays specific for IgE against α-gal, beef, and pork were also negative. She was diagnosed with an α-gal -unrelated red meat allergy following the reproduction of urticaria by a food challenge test. The patient was unresponsive to several drugs, including anti...
Source: Case Reports in Dermatology - September 6, 2021 Category: Dermatology Source Type: research
Darier ’s Disease Flare following COVID-19 Vaccine
We present a case of a 47-year-old white female with a flare of Darier’s disease 2 days following her first vaccination with COVID-19 vaccine (ChAdOx1-s [recombinant]) (Vaxzevria® [previously known as COVID-19 vaccine AstraZeneca]). In this case report, we discuss possible mechanisms linking the vaccination and the flare of Darier ’s disease. We consider inflammatory mechanisms as well as a random co-occurrence. Due to the close time-related association between the disease flare and the COVID-19 vaccination, we find an urge to make other clinicians aware of a possible association.Case Rep Dermatol 2021;13:432 –436 (...
Source: Case Reports in Dermatology - August 18, 2021 Category: Dermatology Source Type: research
Ulcerative Lupus Vulgaris on the Wrist
We report a case of ulcerative lupus vulgaris (LV) in a unique site, which facilitated the detection of internal organ tuberculosis (TB). A 68-year-old Japanese man presented with a reddish ulcerated painless lesion on his right wrist that had initially appeared 4 weeks earlier as a nontender nodule. There was no recent history of fever, weight loss, or cough. The results of tissue culture, PCR, and contrast-enhanced chest computed tomography were consistent with the diagnosis of ulcerative LV with underlying pulmonary TB and tuberculous lymphadenitis. The patient was started on anti-TB therapy. After 1 month of therapy, e...
Source: Case Reports in Dermatology - August 10, 2021 Category: Dermatology Source Type: research
Digital Papillary Adenocarcinoma: Case of a Rare Malignant Cutaneous Tumor of the Eccrine Sweat Gland
This article presents a case of long-standing, previously undiagnosed DPA. The lesion appeared more inconspicuous on gross examination than other reports in the literature, and diagnosis was made with punch biopsy and confirmed postsurgically. To date, the patient has not had recurrence, although she is being monitored for potential metastatic deposits in her lungs. Clinical dermatologists should be aware of the high mortality burden this lesion may inflict if left undiagnosed or mistreated.Case Rep Dermatol 2021;13:422 –427 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 6, 2021 Category: Dermatology Source Type: research
Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
Blue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation (VM) that may affect any tissue or organ but mainly affects the skin, subcutaneous tissue and gastrointestinal (GI) tract. Patients present with serious anemia, treated with lifelong iron supplements and frequent blood transfusion secondary to chronic GI bleeding. Variable therapeutic modalities were used in the management of BRBNS; sirolimus (SRL), a mammalian target of rapamycin (mTOR) inhibitor, is found to be a promising therapy for vascular anomalies.Case Rep Dermatol 2021;13:417 –421 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - July 29, 2021 Category: Dermatology Source Type: research
Pseudomonas-Contaminated Pool Triggering an Episode of Idiopathic Palmoplantar Hidradenitis
We report a case of a 3-year-old girl who presented with IPPH after swimming in a pool with evidence ofP. aeruginosa contamination, further solidifying the association between Pseudomonas and IPPH.Case Rep Dermatol 2021;13:411 –416 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - July 26, 2021 Category: Dermatology Source Type: research
Lichen Planus Pigmentosus Inversus: A Rare Subvariant of Lichen Planus Pigmentosus
Lichen planus pigmentosus inversus (LPPI) is a rare subvariant of Lichen planus pigmentosus (LPP), presenting with sharply defined brown to gray macules, papules, and plaques limited to the intertriginous areas, with only a few cases reported in the medical literature so far. While LPP mostly affects patients with Fitzpatrick skin type III –IV in sun-exposed areas such as the neck, LPPI is seen in Caucasians and spares sun-exposed areas. Skin lesions tend to be very refractory to treatment attempts including potent topical steroids and oral corticosteroids. Given the increased penetration of potent topical steroids and t...
Source: Case Reports in Dermatology - July 26, 2021 Category: Dermatology Source Type: research
Symmetrical Facial Giant Plaque-Type Juvenile Xanthogranuloma: Case Report and Review of the Literature
Juvenile xanthogranuloma (JXG) is the most common type of non-Langerhans cell histiocytosis. JXG is a rare benign tumor, which may be present at birth or develop later. The classical form of JXG is characterized by a red-yellowish benign papule or nodule with predilection sites on the head, neck, and trunk, although lesions can appear on extremities or extracutaneous sites. In most cases there is only one lesion, whereas numerous papules or nodules may occur. Special forms of JXG such as mixed, giant, subcutaneous, eruptive, clustered, and plaque-like have been reported and associations between JXG and systemic diseases ha...
Source: Case Reports in Dermatology - July 19, 2021 Category: Dermatology Source Type: research
