A Case of Male Genital Psoriasis without Involvement of the Glans Penis
We present the first reported case of chronic plaque psoriasis affecting the penile shaft without involvement of the glans. Both consistent histologic and non-cutaneous features of psoriasis facilitated diagnosis in this patient. The sclerotic plaque on the patient ’s penile shaft resolved following biologic therapy for psoriasis. This rare presentation of genital psoriasis highlights important learning points for clinicians and dermatopathologists. First, genital psoriasis may affect the penile shaft without involvement of the glans penis. Second, non-cutan eous signs of psoriasis can inform diagnosis when clinical pres...
Source: Case Reports in Dermatology - March 29, 2022 Category: Dermatology Source Type: research
Cutaneous Metal Hypersensitivity Reaction
A 53-year-old lady underwent a left total knee arthroplasty. She developed a dermatitis over the left knee on postoperative day 5, which worsened over the next 2 weeks and spread to the trunk despite regular topical corticosteroids and oral antihistamines. Physical examination revealed an erythematous plaque over the left knee and urticated plaques over the neck. She was given a course of oral and topical corticosteroids with resolution. Subsequent patch testing showed a showing ++ reactions to gold and nickel, and + reactions to copper, palladium, rhodium, titanium, vanadium, zinc, and hydroquinone. Orthopedic implants co...
Source: Case Reports in Dermatology - March 29, 2022 Category: Dermatology Source Type: research
Secondary Adrenal Insufficiency in a Patient with Metastatic Melanoma Treated with Nivolumab
We report a case of secondary adrenal insufficiency due to nivolumab. An 83-year-old man with acral lentiginous types of melanoma on the right sole visited our department in March 2017. He received primary surgery at referred hospital in June 2017, and pathological stage was IIIC (pT3bN3M0) according to AJCC (American Joint Committee on Cancer) 7th edition criteria. During the follow-up period, a lot of in-transit metastases appeared on the right leg. While we were resecting in-transit metastases, we concurrently started nivolumab in September 2018. After 17 cycles of nivolumab treatment, he developed severe nausea and ano...
Source: Case Reports in Dermatology - March 21, 2022 Category: Dermatology Source Type: research
Intralesional Avirulent Bacillus Calmette-Gu érin Injection as a Promising Method for the Treatment of Tuberculosis Verrucosa Cutis
Cutaneous involvement is a relatively uncommon manifestation of tuberculosis (TB), particularly outside the endemic regions. Cutaneous TB manifests itself in various clinical forms, depending on the host ’s immune status and mode of transmission. Nonetheless, the same treatment regimen is recommended for every subtype. Tuberculosis verrucosa cutis (TBVC) is a specific subgroup in which the affected persons are usually healthy adults who are vaccinated or exposed to mycobacteria during their occupa tional activities. These patients have the ability to launch a strong cellular immune reaction against mycobacteria. In this ...
Source: Case Reports in Dermatology - March 21, 2022 Category: Dermatology Source Type: research
Successful Treatment of Nail Lichen Planus with a Lacquer Containing Urea, Keratinase, and a Retinoid Molecule: Report of 10 Cases
Lichen planus is chronic inflammatory mucocutaneous disease. Involvement of nails (nail lichen planus: NLP) could be the only manifestation or it could be associated with the other typical skin and mucous localizations. Typical NLP alterations are linear nail bed dyschromia, longitudinal ridging, splitting, onycholysis, and subungual hyperkeratosis. Pterygium could be observed in advanced stages. Treatment of NLP is challenging. Limited clinical data have suggested that both oral and topical retinoids could be beneficial. Recently, a nail lacquer containing urea (20%), keratinase fromBacillus licheniformis, and hydroxipina...
Source: Case Reports in Dermatology - March 21, 2022 Category: Dermatology Source Type: research
Topical Corticosteroid-Induced Adrenal Insufficiency: A Case Report
Topical Corticosteroids (TCS) are the most commonly prescribed medications in Dermatology practice. They are considered safe and effective if used at the appropriate location and for the appropriate duration. Local side effects due to TCS are not uncommon. However, systemic side effects are rare. Herein, we present a patient who developed adrenal insufficiency secondary to the use of TCS.Case Rep Dermatol 2022;14:39 –42 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 21, 2022 Category: Dermatology Source Type: research
Radiotherapy, Utilizing Volumetric Modulated Arc Therapy, for Extensive Skin Field Cancerization: A Retrospective Case Series Assessing Efficacy, Safety, and Cosmetic Outcomes at 12 Months After Treatment
Extensive Skin Field Cancerization (ESFC) describes multiple actinic keratoses, with and without keratinocyte skin cancers. These areas are characterised by dysplastic keratoses, are prone to new malignancies, involve significant morbidity, have a poor cosmetic appearance, and impact negatively on quality of life. Available topical field therapies have limited durability of efficacy. Volumetric modulated arc therapy (VMAT) is an advanced form of intensity-modulated radiotherapy which achieves highly modulated and conformal dosimetry, delivering a homogeneous dose, particularly over curved surfaces, for example, scalps and ...
Source: Case Reports in Dermatology - March 10, 2022 Category: Dermatology Source Type: research
Severe Vulvar and Perianal Crohn ’s Disease: A Case Report and Review of the Literature
Case Rep Dermatol 2022;14:24 –30 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 1, 2022 Category: Dermatology Source Type: research
Demodicosis Associated with Wearing a Face Mask: A Case Report
Demodex mites are common ectoparasites of human pilosebaceous units that do not cause any skin symptoms. However, when there is an abnormal increase inDemodex mite density, it can cause multiple skin disorders which are grouped under the term demodicosis. During the COVID-19 outbreak, public health authorities worldwide recommend people to wear face masks when in public places to reduce respiratory transmission. Wearing face mask can cause changes in microenvironment, skin barrier function, and microbiome on human skin. There are several reports of facial skin diseases such as atopic dermatitis, seborrheic dermatitis, acne...
Source: Case Reports in Dermatology - February 15, 2022 Category: Dermatology Source Type: research
Serologic Abnormalities in Macular Lymphocytic Arteritis with Case Presentation
We present a case of MLA with multiple serologic abnormalities, including those that have yet to be reported, such as anti-U1 ribonucleotide protein, anti-RNA polymerase III, anti-smith, and anti-proteinase 3 antibodies. We also provide a brief review of this unfamiliar entity with a focus on the appropriate workup.Case Rep Dermatol 2022;14:12 –18 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - January 17, 2022 Category: Dermatology Source Type: research
Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report
We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.Case Rep Dermatol 2022;14:6 –11 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - January 10, 2022 Category: Dermatology Source Type: research
On the Nose: Anti-MDA-5 Dermatomyositis Manifesting as Perinasal Swelling
In this report, we describe perinasal edema and erythema as a presenting complaint of anti-MDA5 DM in an otherwise healthy 40-year-old woman. The edema began shortly after heavy sun exposure and was followed by painful papules in her hands and arthritis within a few weeks. She was found to have high titer of anti-CCP and anti-MDA5, and thus was diagnosed with DM and rheumatoid arthritis overlap. A CT chest, abdomen, and pelvis showed patchy ground-glass and interstitial opacities in bilateral lower lobes consistent with mild interstitial lung disease without evidence of malignancy. Perinasal cutaneous findings and arthralg...
Source: Case Reports in Dermatology - January 10, 2022 Category: Dermatology Source Type: research
Acral Necrosis in a COVID-19-Infected Man Treated with Botulinum Toxin Type A
COVID-19 has been associated with acral ischemia and digital necrosis. Standard treatment of acral ischemia and digital or acral necrosis includes ongoing therapy with vasodilators and anticoagulants. However, these treatments are not always efficient to avoid the progression of necroses, which in the worst case can lead to amputation. Here, we report a case in which interdigital Botox® (botulinum toxin type A) nerve cord injection stopped the progression of acral necroses arising from an underlying vasculopathy due to COVID-19. Moreover, Botox® injection eliminated inflammation in the affected acral area within 2 weeks....
Source: Case Reports in Dermatology - December 27, 2021 Category: Dermatology Source Type: research
Paraneoplastic Filiform Hyperkeratosis and Immunoglobulin-Associated Vasculitis in Myeloma Progression: A Case Report
We report on a patient with diffuse filiform hyperkeratosis and immunoglobulin-associated vasculitis in a severe progression of a known myeloma.Case Rep Dermatol 2021;13:563 –567 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - December 23, 2021 Category: Dermatology Source Type: research
Newly Developed Psoriasis in a Patient with Telangiectasia Macularis Eruptiva Perstans and Systemic Mastocytosis Treated with Interferon
The authors present a rare case of a patient with telangiectasia macular eruptiva perstans, with confirmed D816V mutation which later progressed to systemic mastocytosis confirmed by trepanobiopsy. First-line treatment – phototherapy – had to be stopped, and systemic treatment with interferon alpha-2a was initiated. The treatment was successful with regression of skin lesions as well as mast cell infiltrates in the bone marrow. However, the treatment was complicated by the onset of psoriasis lesions.Case Rep Dermatol 2021;13:558 –562 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - December 7, 2021 Category: Dermatology Source Type: research
