Malignant Melanoma within a Cellular Blue Nevi Presenting as a Vascular Malformation and the Connection to Sporadic KRAS Mutations
We present a case of malignant melanoma (MM) developing within a vascular malformation showing features of cellular blue nevi. A 47-year-old male presented with acute symptoms of a temporal and zygomatic mass, which were both previously asymptomatic upon development 30 years ago. These masses were diagnosed as vascular malformations upon imaging and were treated with sclerotherapy. Embolization and surgical excision were performed 3 years later due to symptomatic growth. Final pathology reports showed MM with congenital blue nevi. We hypothesize a possible linkage to a sporadicKRAS mutation, linking both presentations of v...
Source: Case Reports in Dermatology - June 18, 2021 Category: Dermatology Source Type: research
Cutaneous Horn of the Glans
Cutaneous horn is a protuberance constituted by compact keratinous material, with a hard consistence similar to a horn, which occurs more frequently in photoexposed areas. The authors describe a case of cutaneous horn on the glans considered a rare location. Verrucous carcinoma was the histopathological diagnosis of the base of the horn and lichen sclerosis, the precursor lesion.Case Rep Dermatol 2021;13:304 –309 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 17, 2021 Category: Dermatology Source Type: research
Sirolimus for the Management of Verrucous Venous Malformation: A Case Report and Literature Review
Verrucous venous malformation (VVM) is a vascular malformation that is rarely reported in the literature which has vascular and hyperkeratotic components affecting mainly the extremities, difficult to treat, and often associated with complications mainly bleeding, ulceration with secondary infections, and limitation of movement. In this article, we report a successful improvement of VVM with sirolimus.Case Rep Dermatol 2021;13:298 –303 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 17, 2021 Category: Dermatology Source Type: research
GFAP-Negative Subcutaneous Sacrococcygeal Extraspinal Ependymoma
Ependymomas are slowly growing glial tumors derived from the ependymal cells and usually occur in the central nervous system (CNS). Ependymomas rarely occur outside of the CNS and they are called extraspinal ependymomas. In spite of their metastatic potential, extraspinal ependymomas can be misdiagnosed for other benign mass like pilonidal cysts. The diagnosis is confirmed by histopathology and most of the cases are known to show glial fibrillary acidic protein (GFAP), S-100 protein, and keratin (AE1AE3) immunoreactivity. Herein, we present a case of GFAP-negative ependymoma, which presented as asymptomatic subcutaneous tu...
Source: Case Reports in Dermatology - June 14, 2021 Category: Dermatology Source Type: research
Distant Resolution of Actinic Keratosis following Cryosurgery: An Unusual Phenomenon
Early after the introduction of cryosurgery to clinical practice, there were reports of metastasis regressing after cryosurgery of a primary tumour, mainly prostate and breast cancer, suggesting a systemic immunological effect to a local reaction. Colleagues within dermatology have occasionally experienced similar systemic effects following cryosurgery. However, published reports of such cases are lacking. In this case, we report a photographed distant resolution of an actinic keratosis (AK) on 68-year-old woman ’s arm following cryosurgery of another AK on the same arm.Case Rep Dermatol 2021;13:289 –292 (Source: Case ...
Source: Case Reports in Dermatology - June 14, 2021 Category: Dermatology Source Type: research
Annually Recurring Erythema Annulare Centrifugum: A New Case Series with Review of the Literature
We describe 5 new cases and present a review of the literature. Patients were 3 females and 2 males with an age range of 25 –55 years. Multiple annular plaques were located at the thighs in 4 patients and the neck in one patient. In 1 patient, a single lesion was present. Plaques were recurring in summer in 3 cases; in 1 case, in spring; and another patient, in winter since 3–4 years. Lesions were self-healing in few days or weeks. Histologically, the epidermis presented mild acanthosis with patchy spongiosis, slight parakeratosis, and mild exocytosis. There was a perivascular lympho-histiocytic infiltrate of variable ...
Source: Case Reports in Dermatology - June 10, 2021 Category: Dermatology Source Type: research
Dominance of Methicillin-Resistant < b > < i > Staphylococcus aureus < /i > < /b > in a Japanese Infant with Recessive Dystrophic Epidermolysis Bullosa
A male infant had the very fragile skin and easily formed bullas by rubbing and scratching from his birth. He was diagnosed with severe recessive dystrophic epidermolysis bullosa (RDEB) due to the lack of type VII collagen by performing an immunofluorescence mapping method from a skin biopsy specimen of the patient ’s bulla. We analyzed the skin microbiome using next-generation sequencer. The species from the patient’s skin revealed the dominance ofStaphylococcus aureus (S. aureus) similar to the reports from Austria and Chile severe RDEB patients, and these results are same as the pattern isolated from the skin of ato...
Source: Case Reports in Dermatology - June 8, 2021 Category: Dermatology Source Type: research
A Rare Occurrence of Sebaceous Carcinoma, Sebaceoma, Syringocystadenoma Papilliferum, and Trichoblastoma in a Single Nevus Sebaceous Lesion
We report a case of multiple secondary tumors, such as sebaceoma, sebaceous carcinoma, syringocystadenoma papilliferum, and trichoblastoma, in a single NS lesion.Case Rep Dermatol 2021;13:271 –277 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 8, 2021 Category: Dermatology Source Type: research
Diffuse Facial Hyperpigmentation as a Presenting Sign of Lupus Erythematosus: Three Cases and Review of the Literature
Lupus erythematosus (LE) is an autoimmune disorder commonly affecting the skin; cutaneous lesions may indicate systemic involvement, warranting further evaluation. Photosensitivity, which may result in hyperpigmentation, is a well-known feature of the disease. In contrast, the prevalence of primary hyperpigmentation as a presenting sign of LE is not well established. Here, we compare 3 unique cases of diffuse facial hyperpigmentation as the primary manifestation of LE (cutaneous or systemic) and review previously reported cases. Our data highlight the need for considering LE in the differential diagnosis of facial hyperpig...
Source: Case Reports in Dermatology - June 8, 2021 Category: Dermatology Source Type: research
Morphea as Part of the Dermatological Manifestation of Celiac Disease: Case Presentation and Review of the Literature
We present an interesting case report of a 10-year-old child with a recent diagnosis of celiac disease presenting with morphea. Following treatment and adherence to a gluten-free diet, the morphea rapidly resolved. We suggest a possible relationship between the two entities and give a brief review of the relevant literature. We suggest that morphea might be one of the many dermatological manifestations of celiac disease, with possible implications for the need to screen patients with morphea for celiac disease.Case Rep Dermatol 2021;13:257 –262 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - May 27, 2021 Category: Dermatology Source Type: research
Atopic Dermatitis Treated Safely with Dupilumab during Pregnancy: A Case Report and Review of the Literature
We report a case of severe atopic dermatitis treated safely with dupilumab during pregnancy with no adverse maternal or fetal outcomes observed. Our case highlights that dupilumab use in pregnancy has its place but should always be preceded by careful assessment of the risks and benefits. Clinicians are encouraged to enroll their patients in relevant pregnancy registry studies to monitor outcomes in women exposed to dupilumab during pregnancy and lactation.Case Rep Dermatol 2021;13:248 –256 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - May 4, 2021 Category: Dermatology Source Type: research
Bulky Condyloma Acuminata following Ustekinumab Treatment for Plaque Psoriasis: A Case Report
We report a case of a patient treated for chronic plaque psoriasis with ustekinumab who developed bulky condyloma acuminata shortly after initiating the treatment. Although ustekinumab has already been described in literature associated with other forms of human papilloma virus skin infections, this is the first case to our knowledge in which ustekinumab is associated with genital warts.Case Rep Dermatol 2021;13:244 –247 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 21, 2021 Category: Dermatology Source Type: research
Two Cases of Cutaneous Adverse Effects Induced by Tumor Necrosis Factor-Alpha Inhibitors
Here, we report two cases of cutaneous adverse effects possibly induced by the use of tumor necrosis factor-alpha (TNF- α) inhibitors. The first case presented alopecia areata (AA) and atopic dermatitis (AD) that developed during the treatment of ulcerative colitis using infliximab; the other case presented urticaria and AD that developed during the treatment of rheumatoid arthritis using etanercept. AA, AD, and urt icaria are relatively common skin diseases; however, they are not well known as adverse effects of TNF-α inhibitors. Although immunological studies were not performed, the clinical courses suggested that thes...
Source: Case Reports in Dermatology - April 19, 2021 Category: Dermatology Source Type: research
Pseudoxanthoma Elasticum: Report of Two Cases
Elastic pseudoxanthoma is a rare disease with autosomal recessive inheritance, also known as Gr önblad-Strandberg syndrome, characterized by pathological mineralization of the elastic fibers in the connective tissue, affecting principally the dermis of skin, media, and intima of blood vessels and Bruch’s membrane of the eye. The genetic defect of the disorder is located on chromosome 16p13. 1 and disease is caused by the lack of functional ABCC6 protein, which in turn causes extracellular accumulation and deposition of calcium and other minerals in the elastic tissue. In this article we present two cases of this rare di...
Source: Case Reports in Dermatology - April 19, 2021 Category: Dermatology Source Type: research
Anti-MDA5 Antibody-Positive Interstitial Pneumonia with Autoimmune Features Presenting as Amyopathic Hypodermatitic Dermatomyositis: A Case Report
Dermatomyositis (DM) and its variant, clinically amyopathic DM, are widely recognized entities. DM sine dermatitis, a variant without skin involvement, is less widely reported. DM with neither muscle nor skin manifestations has not been reported. We herein describe the first account of a patient with a myositis-specific antibody presenting with an array of clinical findings in the absence of both muscle and pathognomonic skin disease. This case report details the multidisciplinary assessment of an anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive individual with inflammatory polyarthropathy, mucocuta...
Source: Case Reports in Dermatology - April 19, 2021 Category: Dermatology Source Type: research
