Delayed Diagnosis of Vulvar Crohn ’s Disease in a Patient with No Gastrointestinal Symptoms
We describe a patient with long-standing, painful vulvar Crohn’ s lesions with no gastrointestinal manifestations of the disease. Her diagnosis was delayed for years, and initial therapy with antibiotics and steroids was unsuccessful. Finally, the patient experienced effective and long-lasting symptom improvement with infliximab (RemicadeTM).Case Rep Dermatol 2018;10:263 –267 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 28, 2018 Category: Dermatology Source Type: research
Phototoxic Reaction Induced by Pazopanib
We present here the first case of pazopanib-induced phototoxic drug reaction in a patient with renal cell carcinoma.Case Rep Dermatol 2018;10:251 –256 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 21, 2018 Category: Dermatology Source Type: research
Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman
Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. A 3-mm punch biopsy confirmed the diagnosis of a well-differentiated KA-type spinous cellular...
Source: Case Reports in Dermatology - November 14, 2018 Category: Dermatology Source Type: research
Atypical Manifestation of Disseminated Sporotrichosis in an AIDS Patient
We report the case of a 47-year-old female, with HIV and disseminated sporotrichosis, presenting molluscum-like skin lesions, as well as lung, nasal, and oral mucosa involvement. We also report the first demonstration of culture ofSporothrix in scales of the skin lesion, a fact not identified in the consulted literature.Case Rep Dermatol 2018;10:231 –237 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - October 24, 2018 Category: Dermatology Source Type: research
Allergic Contact Dermatitis and Autoeczematization to Proctosedyl ® Cream and Proctomyxin® Cream
We present three cases of an autoeczematization (ID) reaction to varying topic al allergens found in Proctosedyl®/Proctomyxin®. It is our recommendation that physician and patient education, avoidance of allergens (or cross-reactants), and appropriate choice of topical corticosteroid is important in preventing and avoiding flares.Case Rep Dermatol 2018;10:238 –246 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - October 24, 2018 Category: Dermatology Source Type: research
Anti-Centromere Antibody Positivity in a Patient with Generalized Morphea
We report the case of a 45-year-old female with generalized morphea (GM), who exhibited positivity for the anti-centromere antibody (Ab). She frequently developed multiple sclerotic skin lesions, whose histological findings were compatible with morphea. She demonstrated favorable responses to topical and oral steroids. Cases of GM associated with systemic sclerosis (SSc)-specific Abs (anti-Scl-70 Ab, anti-centromere Ab, and anti-RNA polymerase III Ab) have rarely been reported. The previously reported GM cases involving anti-SSc-specific Abs exhibited some skin manifestations of SSc, such as nailfold capillary changes. How...
Source: Case Reports in Dermatology - October 18, 2018 Category: Dermatology Source Type: research
A Case of Primary Cutaneous Basal Cell Carcinosarcoma
We report here a case of cutaneous basal cell carcinosarcoma and a review of the literature.Case Rep Dermatol 2018;10:208 –215 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 2, 2018 Category: Dermatology Source Type: research
Case Study of Onychomycosis Patients Treated with 1,064-nm Nd:YAG Laser
The objectives of this study were to assess the therapeutic response of patients with onychomycosis to 1,064-nm Nd:YAG laser treatment, the clinical evaluation meth od available for this therapy, and the possible side effects of this treatment. Twenty patients with onychomycosis underwent laser therapy. A total of 34 nails with onychomycosis were assessed according to the Onychomycosis Severity Index (OSI). This index generates scores that classify onychomycosi s as mild, moderate, or severe. The OSI was determined before treatment and after a mean follow-up period of 8 months. The comparison between the initial and the fi...
Source: Case Reports in Dermatology - September 2, 2018 Category: Dermatology Source Type: research
Recurrent Granuloma Gluteale Infantum Secondary to Fecal Overflow Incontinence
We present the case of a 3-year-old boy with recurrent episodes of granuloma gluteale infantum which resolved with treatment of his fecal overflow incontinence. As each recurrence correlated with a relapse of overflow incontinence, in this case the cause was irritant contact dermatitis from the liquid stool. This is the first reported case of recurrent granuloma gluteale infantum.Case Rep Dermatol 2018;10:203 –207 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 23, 2018 Category: Dermatology Source Type: research
Psoriasis Vulgaris Exacerbation during Treatment with a PD-1 Checkpoint Inhibitor: Case Report and Literature Review
Conclusion: Psoriasis exacerbation is an established side effect of PD-1/PDL-1 checkpoint inhibitors with 35 reported cases. Early recognition and management are challenging as there are no clear guidelines available. A close collaboration between oncologist and dermatologist is mandatory to manage this immune-related adverse event.Case Rep Dermatol 2018;10:190 –197 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 9, 2018 Category: Dermatology Source Type: research
Atezolizumab-Induced Stevens-Johnson Syndrome in a Patient with Non-Small Cell Lung Carcinoma
Atezolizumab is a humanized anti-PD-L1 immune checkpoint antibody that is currently used in many kinds of advanced carcinoma including metastatic non-small cell lung cancer. The cutaneous side effect profile reported only 20% of the patients which had only mild maculopapular rash that required no treatment. There is no case report of anti-PD-L1 antibody-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) eruptions. To the best of our knowledge, there is no case report of atezolizumab-induced SJS or SJS/TEN induced by anti-PD-L1 immune checkpoint antibodies. We believe that our report will be useful to d...
Source: Case Reports in Dermatology - August 9, 2018 Category: Dermatology Source Type: research
Low Back Pain in Hidradenitis Suppurativa: A Diagnosis Not to Miss!
We report the case of a patient suffering from hidradenitis suppurativa since puberty and complaining of chronic low back pain associated to altered sensitivity and muscular weakness in the right leg. A diagnosis of lumbosciatica was confirmed. Symptoms were not relieved after the use of nonsteroidal anti-inflammatory drugs and analgesics. A surgical decompression was then indicated but heavily debated. Indeed, extended inflammatory and fibrotic hidradenitis suppurativa lesions were located regarding the skin area eligible for the proposed surgery. A combined therapy with clindamycine/rifampicin was started and the surgery...
Source: Case Reports in Dermatology - July 12, 2018 Category: Dermatology Source Type: research
Aplasia Cutis Congenita: A Case Report
Conclusions: Aplasia cutis congenita is a rare condition of uncertain etiology, but consanguinity may play a role. Its management depends on its pattern, location, underlying causes, and associated anomalies.Case Rep Dermatol 2018;10:182 –186 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - July 5, 2018 Category: Dermatology Source Type: research
Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis: Exuberant Classic Clinical Picture of a Rare Disease
The authors present a classic case of Churg-Strauss syndrome with an exuberant clinical picture in a 34-year-old woman. She showed the following diagnostic criteria: asthma, polyneuropathy, rhinopathy, marked eosinophilia, positive p-ANCA with a perinuclear pattern, and skin histopathology results suggestive of vasculitis with eosinophils. There was a good response to prednisone, dexamethasone pulse therapy, and cyclophosphamide.Case Rep Dermatol 2018;10:175 –181 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 29, 2018 Category: Dermatology Source Type: research
Widely Spread Unilateral Inflammatory Linear Verrucous Epidermal Nevus (ILVEN)
In this report, we describe a case of widely spread unilateral ILVEN that clinically and histologically mimicked psoriasis vulgaris and could be diagnosed by immunohistochemical staining focused on the IL-36γ/IL-17A axis.Case Rep Dermatol 2018;10:170 –175 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 14, 2018 Category: Dermatology Source Type: research
