Successful Treatment of Hard Corns in Two Patients Using Microwave Energy
Corns are a common foot problem accounting for nearly half of all problems seen within podiatry and chiropody clinics. Hard corns are concentrated areas of hyperkeratosis within the stratum corneum, typically found on the weight-bearing (plantar) surfaces of the feet. For many patients, they are a source of pain and have been shown to negatively affect a patient ’s activity and quality of life. Most of the currently available treatments are short-lived in their effectiveness, with corns frequently being recurrent, requiring repeated visits to remove the painful lesions. The use of handheld microwave devices indicated for...
Source: Case Reports in Dermatology - November 5, 2020 Category: Dermatology Source Type: research
Recurrent Ulcerations in an 84-Year-Old Male Diagnosed with Hailey-Hailey Disease
Hailey-Hailey disease (HHD), or familial benign chronic pemphigus, is a rare inherited acantholytic dermatosis. It is an autosomal dominant disease affecting the intertriginous areas. HHD has been characterized by flaccid blisters, erosions, and macerations that are limited to flexural (friction-prone) areas. The painful blisters and erosions significantly decrease patients ’ quality of life. There are multiple types of therapy related to this disorder. Many of the studies have suggested benefits from steroid therapy in addition to oral antibiotics.Case Rep Dermatol 2020;12:209 –212 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 5, 2020 Category: Dermatology Source Type: research
A Longstanding, Persistent and Recurrent Case of Cryptogenic Panniculitis
We describe a 54-year-old woman who had received a diagnosis of SPTCL based upon a left parietal scalp biopsy 5 years earlier. This diagnosis was supported by immunohistochemistry (IHC) demonstrating a CD8+ predominant lymphocyte population in the subcutis. T-cell gene rearrangement studies were not performed at that time. The patient was treated and showed significant clinical improvement. When several tender erythematous subcutaneous nodules appeared on the upper back, left plantar surface and pretibial region, repeat biopsy was performed. Histology revealed a lobular and septal panniculitis with no vasculitis. The infil...
Source: Case Reports in Dermatology - November 4, 2020 Category: Dermatology Source Type: research
CD10-Positive Cutaneous PEComa: An Extremely Rare Skin Tumour
We here present the case of a 67-year-old woman with a history of a slowly progressive, polypous nodule on her left wrist. The lesion was excised, and the histological analysis revealed a clear cell tumour that was relatively sharply demarked from the surrounding tissue extending into the subcutaneous tissue. The tumour showed a characteristic trabecular pattern in which the tumour cells were arranged around numerous vessels. The neoplastic cells had a predominantly epithelioid shape, granular eosinophilic to clear cytoplasm and prominent centrally located nucleoli. The histological differential diagnosis included a metast...
Source: Case Reports in Dermatology - November 2, 2020 Category: Dermatology Source Type: research
Schimmelpenning Syndrome with Large Nevus Sebaceous and Multiple Epidermal Nevi
Epidermal nevus syndromes are a group of rare multiorgan disorders. Schimmelpenning syndrome is a clinical variant of epidermal nevus syndromes. This congenital syndrome is characterized by the existence of nevus sebaceous and usually accompanied by abnormalities of the eyes, skeletal, cardiovascular, and central nervous systems. A 2-year-old girl presented with large, hairless, yellowish-brown plaques on the scalp and face along with multiple brownish-black verrucose plaques and brownish-black macules on almost all parts of the body. The skin-colored verrucose tumors were also found on the lips and around the mouth. Histo...
Source: Case Reports in Dermatology - October 30, 2020 Category: Dermatology Source Type: research
Trichostasis Spinulosa: A Case Report with an Unusual Presentation
Trichostasis spinulosa (TS) is a follicular disorder characterized by the retention of multiple vellus hairs in a hyperkeratotic dilated hair follicle. TS is considered as a common disorder; however, it is often underdiagnosed due to its asymptomatic nature. Although the condition frequently affects the face or extremities, the widespread distribution of TS over the entire body has been once reported in a patient with chronic renal failure. To emphasize the infrequent presentation of TS, we herein report a 57-year-old male with an unusual location of TS.Case Rep Dermatol 2020;12:178 –185 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - October 30, 2020 Category: Dermatology Source Type: research
Omalizumab Use in Chronic Spontaneous Urticaria during Pregnancy and a Four Years ’ Follow-Up: A Case Report
Chronic spontaneous urticaria (CSU) is a benign skin disorder usually responsive to treatment; however, at times it can be difficult to control and become very debilitating. We discuss the case of a woman with CSU that was unresponsive to H1-antihistamines who was treated with omalizumab and became pregnant during omalizumab treatment. We also considered the follow-up of the mother and newborn for 4 years after delivery. Our case report confirms that omalizumab is a safe and effective therapeutic option, after careful evaluations in terms of cost-effectiveness, in pregnant and lactating women with severe chronic urticaria....
Source: Case Reports in Dermatology - October 8, 2020 Category: Dermatology Source Type: research
Fatal Disseminated Mucormycosis in a Hematological Immunocompromised Patient with Extensive Voriconazole Exposure: A Case Report and Review of the Literature
Disseminated mucormycosis is a rare, opportunistic, and aggressive infection typically presenting in immunocompromised patients. Herein, we report a 55-year-old male with a past medical history of Philadelphia-negative B-cell acute lymphoblastic leukemia who presented with a 2-month history of non-painful necrotic ulcers on the nose, knuckles, elbow, foot, and scrotum following 3 months of voriconazole (VRC) exposure in the setting of an unrelated fungal pneumonia. Our case reinforces the virulent and often fatal nature of the disease amongst immunocompromised patients, along with extensive VRC exposure as a possible suppl...
Source: Case Reports in Dermatology - October 8, 2020 Category: Dermatology Source Type: research
Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options
Darier disease is a rare type of autosomal dominant genodermatosis, and it is caused by a mutation in the gene coding for the endoplasmic reticulum membrane calcium pump Ca2+-ATPase type 2, leading to compromised intercellular adhesion. Moreover, this condition is characterized by multiple keratotic greasy papules with a seborrheic distribution and is worsened by heat and sun exposure, sweating, and friction. Occasionally, it may be associated with nail abnormalities and may involve the mucosa. Unilateral segmental Darier disease is a rare variant characterized by unilateral eruption of erythematic keratotic papules not as...
Source: Case Reports in Dermatology - September 11, 2020 Category: Dermatology Source Type: research
A Case of Ofuji Disease Successfully Treated with the Combination of Low-Dose Indomethacin and Topical Tacrolimus
Eosinophilic pustular folliculitis (EPF) (Ofuji disease) is a chronic, noninfectious pruritic cutaneous disorder of unknown etiology. No official guidelines are available for its treatment. Herein we present the case of a 59-year-old Caucasian man admitted to our outpatient clinic due to a generalized itchy skin rash characterized by papulo-pustules involving the face, trunk, and limbs. Histological examination supported the clinical diagnosis of EPF (Ofuji disease). The combination of low-dose oral indomethacin and topical tacrolimus ointment once a day led to a complete resolution of the lesions as well as associated sym...
Source: Case Reports in Dermatology - August 18, 2020 Category: Dermatology Source Type: research
Improvement of Psoriasis, Psoriatic Arthritis, and Alopecia Universalis during Treatment with Tofacitinib: A Case Report
Alopecia areata (AA) is the most common immune-mediated hair loss disorder with a life-time prevalence of 2%. The pathogenesis of AA is not completely understood, but interferon gamma (INF- γ) and Janus kinases (JAK) may play a key role. Here, we present a case involving a male patient with psoriasis and psoriatic arthritis, who exhibited a rapid hair loss, diagnosed as AA, during ciclosporin treatment. As ciclosporin was unable to control his psoriasis, the treatment was changed to m ethotrexate injections, but the hair loss progressed into alopecia universalis. During treatment with the oral JAK inhibitor tofacitinib, t...
Source: Case Reports in Dermatology - August 18, 2020 Category: Dermatology Source Type: research
Angiosarcoma of the Auricle in a Patient with Xeroderma Pigmentosum Variant
We report a 73-year-old Japanese man with angiosarcoma of the auricle and an XP-variant, which is a very rare condition. In this case, long-term physical stimulation due to auricular deformation after surgery may have been the cause. Angiosarcoma associated with XP has a better prognosis than common angiosarcoma, perhaps because of the smaller tumor size. As XP patients are at high risk of skin neoplasms, they consult dermatologists regularly, and therefore skin tumors are likely to be detected early.Case Rep Dermatol 2020;12:144 –149 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 18, 2020 Category: Dermatology Source Type: research
Primary Cutaneous Cryptococcosis: An Unusual Injection Site Infection
We describe an unusual case of PCC in an injection site of an immunocompromised patient. The specific case demonstrates a challenging treating dilemma with different alternative treatment choices. In the presented clinical setting, each choice concealed its risks and benefits. We highlight the importance of patient education for taking the appropriate measures for the disinfection of subcutaneous injection sites.Case Rep Dermatol 2020;12:138 –143 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 14, 2020 Category: Dermatology Source Type: research
Use of Anti-IL-17 Monoclonal Antibodies in HIV Patients with Erythrodermic Psoriasis
In conclusion, anti-IL-17 monoclonal antibodies are an effective and promising treatment option for HIV-infected patients with psoriasis.Case Rep Dermatol 2020;12:132 –137 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 12, 2020 Category: Dermatology Source Type: research
Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report
We presently report the case of COVID-19 in a 38-year-old male who had come to the primary health care clinic of Shahid Beheshti University of Medical Sciences, which specializes in the COVID-19 epidemic. He reported having fatigue, myalgia, fever, rash, and loss of taste and smell. The physical findings were maculopapular rash over his trunk, inguinal regions, and left arm, erythema of larynx with an aphthous lesion on left tonsil, he did not have a fever, and respiratory distress symptoms. There were no changes regarding COVID-19 in the spiral lung CT scan. However, the result of PCR for COVID-19 RNA was positive.Case Re...
Source: Case Reports in Dermatology - July 29, 2020 Category: Dermatology Source Type: research
