Multiple Keratoacanthomas after a Recent Tattoo: A Case Report
We report on a 39-year-old man who presented with seven skin lesions on the right thigh 3 weeks after receiving a large tattoo which included red and black pigments. Initially, the lesions grew fast, later their growth stabilized. Histopathology showed well-circumscribed symmetric tumors with a central keratin-filled crater along with further trademarks of a keratoacanthoma. The patient had previously had multiple tattoos with no history of similar lesions. PCR analysis of one of the lesions revealed the presence of human papillomavirus 6. All lesions were excised with a safety margin. A 3-month follow-up revealed no furth...
Source: Case Reports in Dermatology - January 25, 2021 Category: Dermatology Source Type: research
A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
We report a case of pruritic urticarial papules and plaques of pregnancy (PUPPP) starting with target lesions on both forearms at the end of second pregnancy. The patient ’s target lesions became generalized itchy edematous eczema lesions especially on her abdomen extended by pregnancy, which immediately disappeared postpartum. The mechanism PUPPP has not been elucidated so far; however, the typical target lesion was the initial phenotype in the current case. To ap proach the pathophysiology of PUPPP, we examined the cytokine profile in the patient’s serum before and after delivery. The upregulated Th2 cytokine profile...
Source: Case Reports in Dermatology - January 25, 2021 Category: Dermatology Source Type: research
A Diagnostically Challenging Case of Febrile Ulceronecrotic Mucha-Habermann Disease in an Adult Female Successfully Treated with Methotrexate and Cyclosporine
We report the case of a previously healthy 43-year-old woman who presented to the emergency department with 1 month of generalized rash and intermittent fevers. Her only reported new exposure were elective intravenous vitamin infusions received at a medi-spa 1 week prior to onset of lesions. Initial evaluations were inconclusive, and confluent ulceronecrotic, hemorrhagic lesions appeared on approximately 90% of her body despite steroid, antibiotic, and cyclosporine therapy. Repeat histopathology was consistent with PLEVA, and in the context of her clinical presentation she was diagnosed with FUMHD. The patient rapidly atta...
Source: Case Reports in Dermatology - January 21, 2021 Category: Dermatology Source Type: research
Mycosis Fungoides with Dermal Mucin Deposition: An Unusual Variant of the Most Challenging Primary Cutaneous Lymphoma
Mycosis fungoides (MF) is defined as an epidermotropic primary cutaneous T-cell lymphoma composed of small-to-medium-sized T lymphocytes with cerebriform nuclei and with a T-helper phenotype. LeBoit first described an unusual variant of MF with dermal acid mucin deposition. Such a variant was still considered in the list of clinicopathological variants of MF by Cerroni and colleagues. We herein report a case of patch-stage MF with abundant papillary dermal mucin deposition in a clinical setting of an erythematous patch on the lower abdomen and thigh.Case Rep Dermatol 2021;13:7 –11 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - January 14, 2021 Category: Dermatology Source Type: research
Intralymphatic Histiocytosis: An Unusual Presentation
We present a 71-year-old female with a history of psoriasis, 50 pack years smoking and recent Legionnaires disease who came to us complaining of a red to violaceous, blanching, edematous, mi ldly tender lesion covering the left lower lip and extending to the chin and anterior neck. After multiple biopsies, ILH was confirmed and the patient was initially started on tacrolimus 0.1% ointment b.i.d., but there was no response. Then, she was started on oral pentoxifylline and intermittent to pical steroids, as well as continuing the topical tacrolimus. There was again no response, so now she is taking a TNF-ɑ inhibitor as it a...
Source: Case Reports in Dermatology - January 7, 2021 Category: Dermatology Source Type: research
Pseudotumor of the Larynx: A Previously Unreported Side Effect of Apremilast
Apremilast (Otezla ®) is a relatively novel orally administered non-biologic disease-modifying anti-rheumatic drug (DMARD) extensively used in the management of psoriasis and psoriasis arthritis, lately approved for treating oral ulcerations in Behçets disease. Its advantageous side effect profile together with its uncomplicated follow-up and monitoring when compared to other DMARDs facilitates even a broad off-label prescribing. Here, the first case of laryngeal pseudotumor in a patient treated with apremilast for plaque psoriasis is presented.Case Rep Dermatol 2020;12:275 –281 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - December 16, 2020 Category: Dermatology Source Type: research
Don ’t Judge a Tumor by Its Biopsy!
We report a case of giant TB on the forehead of a 75-year-old otherwise healthy woman. Since the age of 20 she reported a bulge on her forehead, in which a superficial-looking wound had now developed. Initially a dermatologist biopsied the tumor suspecting a BCC, which the histological analyses confirmed. The patient was then referred to the Department of Plastic Surgery for complete excision of the carcinoma, including the large frontal bulge. Surprisingly, the concluding pathology report changed the diagnosis from a BCC to a TB. Current management of most skin lesions relies on the histopathological subtype of a single p...
Source: Case Reports in Dermatology - December 2, 2020 Category: Dermatology Source Type: research
An Intriguing Case of Ectopic Benign Migratory Glossitis Resembling Secondary Syphilis: A Case Report
Oral mucosal lesions presenting as erythematous patches usually pose difficulties for a clinical diagnosis. They elicit an array of differential diagnosis that mainly includes oral candidosis, contact mucosal reaction, oral lichenoid lesion, oral psoriasiform, autoimmune disease, and, not to forget, secondary syphilis. In this present case, all those above-mentioned possibilities were ruled out, while secondary syphilis stood as the main diagnosis. As this was also later excluded by a negative serological treponemal test, the final diagnosis rested on an ectopic manifestation of benign migratory glossitis (BMG), whose diag...
Source: Case Reports in Dermatology - November 26, 2020 Category: Dermatology Source Type: research
A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma: Is it Still an Under-Recognized Entity?
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade sweat gland carcinoma characterized by immunoexpression of neuroendocrine markers and mucin production. It occurs most frequently at the head and neck region with strong predilection to the eyelids. Up to 2013, only few cases have been reported. However, in the following years, the number of cases reported has increased significantly, which indicates an upsurge in awareness and increased recognition of this neoplasm. Herein, we describe another case of EMPSGC in a 78-year-old man who presented with a 6-mm skin lesion at the lower eyelid. We discus...
Source: Case Reports in Dermatology - November 23, 2020 Category: Dermatology Source Type: research
Cutaneous Myiasis Caused by < b > < i > Chrysomya megacephala < /i > < /b > in an Infant with Psoriasis Vulgaris
We present a case of cutaneous myiasis caused byChrysomya megacephalain a 3-month-old infant with psoriasis vulgaris. In this case report, we highlight the clinical, histopathologic, taxonomic identification, and treatment of cutaneous myiasis occurring in psoriatic skin.Case Rep Dermatol 2020;12:249 –254 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 23, 2020 Category: Dermatology Source Type: research
Nagashima-Type Palmoplantar Keratosis with Compound Heterozygous Mutations in SERPINB7
Nagashima-type palmoplantar keratosis (NPPK) is a diffuse, non-syndromic (isolated), autosomal recessive palmoplantar keratoderma (PPK) with transgredients. It is characterized by non-progressive mild to moderate transgredient PPK. The mutation inSERPINB7 is reported to underlie the condition. Though many case reports/series have demonstrated various mutations inSERPINB7, the genotype-phenotype correlation in this disorder is still lacking. We herein report two brothers with NPPK. Both patients were found to be compound heterozygous for c.796C#x3e;T and c.650_653delCTGT in theSERPINB7 gene. We then summarize the previously...
Source: Case Reports in Dermatology - November 17, 2020 Category: Dermatology Source Type: research
A Case Report of Prurigo Nodularis-Like Lesions in a Patient with Lepromatous Leprosy
We report a case of a patient with an uncommon clinical pres entation of prurigo nodularis-like lesions without loss of sensation, for which two biopsy specimens demonstrated different histological subtypes. The first was the classic histology of lepromatous leprosy, whereas the other specimen revealed an atypical histoid leprosy variant pattern. This case re port describes a patient with an atypical presentation of leprosy.Case Rep Dermatol 2020;12:236 –240 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 17, 2020 Category: Dermatology Source Type: research
Erythromelanosis Follicularis Faciei et Colli: A Case Report in a Caucasian Male and Brief Review of the Literature
We report the case of a 50-year-old Caucasian male, who had asymptomatic symmetrical facial lesions since the age of 42. His family history was unremarkable. Published erythromelanosis follicularis faciei et colli cases of the last 10 years are summarized in this report to demonstrate the variability and differences in the clinical presentation of this uncommon diagnosis.Case Rep Dermatol 2020;12:231 –235 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 16, 2020 Category: Dermatology Source Type: research
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with < b > < i > Mycoplasma pneumoniae < /i > < /b > Infection
We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection). Possible synergism between previously known drug allergy and the acute Mycoplasma infection may have led to DRESS eruption. Interferon- γ release test and TNF-α release test yielded different patterns in the present case, suggesting a different role for each in different drug eruption types.Case Rep Dermatol 2020;12:225 –230 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 12, 2020 Category: Dermatology Source Type: research
So-Called Butcher ’s Warts Appeared on the Hands of a Meat Handler
We present a case of so-called butcher ’s warts in a meat handler with atopic dermatitis. PCR with direct sequence analysis confirmed the presence of HPV 7 in the hand warts of the patient. Histopathologically, the lesion contained vacuolated cells with centered nuclei, and there were no abundant keratohyalin granules in the granular l ayer. Clinically, HPV 7-induced warts tend to appear on the hands of meat/fish handlers or cutters in the world. Therefore, meat/fish had been thought to act as a vector for the transmission of HPV 7. In our case, the Japanese patient’s occupation required the handling of meat/fish produ...
Source: Case Reports in Dermatology - November 9, 2020 Category: Dermatology Source Type: research
