Acromegaly Presenting with Resistant Acne Vulgaris
Acne vulgaris is one of the most frequent skin diseases worldwide, triggered by multiple endogenous and exogenous factors. Hormones, particularly growth hormone (GH), insulin-like growth factor-1, insulin, CRH, and glucocorticoids, play a major role in the pathogenesis and exacerbation of acne. Excess GH seen in acromegalic patients may result in increased size and function of sweat glands and sebaceous glands, which may contribute to the patient ’s worsening acne and interfere with dermatologic treatment. Therefore, understanding the pathogenesis of acne will help in treating resistant acne by diagnosing and treating th...
Source: Case Reports in Dermatology - May 30, 2022 Category: Dermatology Source Type: research
Post-Irradiation Morphea of the Breast in a Patient with Subacute Cutaneous Lupus Erythematosus: Case Report and a Literature Review
The appearance of morphea after radiotherapy, especially in the context of breast cancer, is a rare but known phenomenon. The incidence of post-irradiation morphea (PIM) of the breast is approximately one in every 500 patients, a higher rate than morphea of any other etiology, which is three per 100,000 per year. PIM usually appears less than 1 year after irradiation (range 1 month to 32 years). The histological pattern of PIM is different from the one in post-irradiation fibrosis, which is a common side effect of radiotherapy and usually appears during the first 3 months after irradiation. Several theories have been propo...
Source: Case Reports in Dermatology - May 30, 2022 Category: Dermatology Source Type: research
A Case of Recalcitrant Circinate Generalized (Lapi ère) Psoriasis Successfully Treated with Risankizumab
Circinate (Lapi ère) psoriasis represents a rare variety of generalized subacute pustular psoriasis clinically characterized by rapid onset of annular circinate lesions with micro-pustules at the borders without classic plaque psoriasis manifestations. Most reported cases have been described in childhood with a re lative benign course, fast and long-term remission after treatment. However, the recalcitrant course may result in an important negative impact on patients’ quality of life. Many systemic treatments have been reported for the management of moderate to severe forms, with variable clinical outcomes. However, dat...
Source: Case Reports in Dermatology - May 30, 2022 Category: Dermatology Source Type: research
Whole Scalp Radiation Therapy for Recurrent Benign Cylindromas
We report a case of a 74-year-old man with a known diagnosis of Brooke-Spiegler syndrome which is a genetic syndrome that results in multiple recurrent cylindromas. He had approximately 70 prior resections to remove recurrent lesions with multipl e grafts. After a large scalp recurrence, with multiple satellite areas, he preferred radiation to the largest site for no-surgical management. After an excellent clinical response, this led to him electing for total scalp irradiation to the remaining sites. He now has a complete response to all rem aining sites.Case Rep Dermatol 2022;14:132 –137 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - May 30, 2022 Category: Dermatology Source Type: research
Rapid Development of Syringocystadenocarcinoma Papilliferum in an Immunosuppressed Liver Transplant Recipient
We report the development of an SCACP over 3 months in a 77-year-old organ transplant recipient undergoing regular dermatological follow-up. The lesion was excised with clear margins with Mohs micrographic surgery. This lesion ’s rapid development and small size contrasts with the predominantly slow-growing, larger lesions described in immunocompetent patients. Lastly, this case further highlights the importance of close dermatological follow-up of immunosuppressed patients.Case Rep Dermatol 2022;14:127 –131 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - May 30, 2022 Category: Dermatology Source Type: research
Hand Dermatitis Secondary to Exposure to Butternut Squash
We present a 28-year-old male who developed dry and flaking skin of his right palm and fingers after coming in contact with butternut squash, which does not typically serve as an allergen that precipitates contact dermatitis. Given the unilateral localization of the dermatitis, timeline of the development of symptoms, and history of contact with butternut squash, the patient likely developed contact dermatitis of the right hand in response to exposure to butternut squash. Contact dermatitis with butternut squash appears to be an uncommon phenomenon, but it may occur more often and not be reported.Case Rep Dermatol 2022;14:...
Source: Case Reports in Dermatology - May 23, 2022 Category: Dermatology Source Type: research
A Case of Papuloerythroderma Successfully Treated with Dupilumab
Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching. Topical or oral corticosteroids are treatment measures, but immunosuppressive drugs are sometimes required. Herein, we report a case of papuloerythroderma treated with dupilumab, a completely humanized immunoglobulin monoclonal antibody against interleukin-4 receptor subunit α (IL-4Rα) of IL-4 and IL-13 receptors, with rapid and marked improvement. Dupilumab is one of the treatment options to treat refractor...
Source: Case Reports in Dermatology - May 23, 2022 Category: Dermatology Source Type: research
Acne Fulminans Induced by Lymecycline in a Patient with Hidradenitis Suppurativa: A Case Report
We present a case of a 16-year-old patient with HS who developed AF following initiation of antibiotic therapy with lymecycline. In the literature, only 2 patients who developed a coexistence of AF and HS have been reported, and there are only 2 other similar cases of AF induced by doxycycline and lymecycline. We consider our case to be of particular interest not only because of the very rare concomitant presence of AF and HS but also because AF was induced by lymecycline, a drug commonly used to treat both acne and HS, and described only once as a drug responsible for AF, so it is an aspect that deserves to be considered ...
Source: Case Reports in Dermatology - May 9, 2022 Category: Dermatology Source Type: research
Acquired Perforating Disorder: A Case with Multiple Underlying Diseases
A 51-year-old man came to the dermatology and venereology outpatient clinic with the complaint of multiple itchy lumps on his body. The patient had a previous history of hemodialysis due to end-stage renal disease. He also had a previous history of hepatitis B, an abnormal liver function test, and high blood sugar. Histopathological examination with Masson ’s trichrome revealed that the patient had extrusion collagen in the epidermis which had invagination. Acquired perforating disorder is frequently misdiagnosed as other skin diseases, thus this condition is underdiagnosed. In addition, underlying diseases frequently as...
Source: Case Reports in Dermatology - May 9, 2022 Category: Dermatology Source Type: research
A Case of Overlapping Clinical Features of Idiopathic Granulomatous Mastitis, Hidradenitis Suppurativa, and Pyoderma Gangrenosum Successfully Treated with Adalimumab
A 36-year-old woman with a 6-month history of painful unilateral mammary nodules and abscesses was initially treated by gynecologists under the diagnosis of idiopathic granulomatous mastitis (IGM). IGM is an entity that has not been described in classical dermatological textbooks and is considered a rare inflammatory breast disease assumingly associated with trauma, infection, or autoimmune system manifestations. In this patient, the lesions were refractory to conventional treatment of IGM comprising of surgical incisions, systemic antibiotics, dexamethasone, and methotrexate. At the initial visit to the dermatology depart...
Source: Case Reports in Dermatology - May 3, 2022 Category: Dermatology Source Type: research
A Case of Brachioradial Pruritus Treated with Chiropractic and Acupuncture
This case report discusses the treatment of brachioradial pruritus (BRP) in a 57-year-old white male veteran with chiropractic and acupuncture. The patient presented with findings consistent with a diagnosis of BRP to include sharp pain, burning, and itching at the bilateral upper extremities over the C5 and C6 dermatomes with acquired excoriations over the affected regions. The only known palliative measure was applying icepacks. Plain film radiographs revealed mild degenerative change at the C4 –C5 and C5–C6 levels and postural evaluation observed anterior head carriage with forward-rounded shoulders. He had pain upo...
Source: Case Reports in Dermatology - April 21, 2022 Category: Dermatology Source Type: research
Nivolumab-Induced de novo Discoid Lupus Erythematosus
We present the first case of nivolumab-induced discoid lupus erythematosus in a patient with hepatocellular carcinoma. The patient presents with violaceous hypopigmented plaques on the pinna bilaterally, hypopigmented plaques with central hyperpigmentation on the posterior neck, and other hypopigmented plaques on the face, forearms, and hands. For management, nivolumab was held for 2 months, and Plaquenil and topical steroids were added. Nivolumab was resumed with no further progression of DLE lesions and improvement of the skin. It is important to characterize cutaneous side effects to effectively manage them.Case Rep Der...
Source: Case Reports in Dermatology - April 21, 2022 Category: Dermatology Source Type: research
Localized Follicular Mucinosis in a Child Treated Successfully with Pimecrolimus and Targeted Phototherapy
We describe a case of FM in a 3-year-old child, which was confirmed on histopathology. The lesion resolved with topical pimecrolimus cream and targeted phototherapy with an excimer lamp and has not recurred.Case Rep Dermatol 2022;14:84 –87 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 5, 2022 Category: Dermatology Source Type: research
Adrenal Insufficiency Secondary to Abrupt Dose Reduction of Topical Corticosteroid Therapy after Starting Brodalumab for Psoriasis: A Case Report
The risk of treating psoriasis with biologic drugs in patients treated with topical corticosteroids over prolonged periods requires careful attention to their underlying adrenal insufficiency because the development of adrenal insufficiency symptoms frequently occurs after cessation of the topical corticosteroids: the dose and duration of topical corticosteroid therapy and etretinate use correlate with risk. In this case report, we present a 65-year-old man with psoriatic erythroderma who developed arthralgia, joint pain, muscle pain, fatigue, and headache after starting brodalumab and a reduction of topical potent cortico...
Source: Case Reports in Dermatology - March 31, 2022 Category: Dermatology Source Type: research
Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to Non-Sun-Exposed Areas
We report a case of SCLE with atypical distribution, following treatment with amlodipine. This highlighted a possible clue that can be used to clinically distinguish a drug-induced case from an idiopathic disorder. A 92-year-old Japanese woman presented with a 2-month history of progressive erythematous, papulosquamous rash, and annular plaques in non-sun-exposed sites with no systemic symptoms. Irbesartan/amlodipine besilate combination tablets were prescribed 8 months earlier for hypertension. The appearance of the skin eruptions, results of immunopathological findings, and temporal relationship between the rash and drug...
Source: Case Reports in Dermatology - March 29, 2022 Category: Dermatology Source Type: research
