A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare painful skin condition that is characterized by hyperpyrexia, peripheral blood and skin neutrophilia, and edematous skin lesions. Necrotizing SS (NSS) is a severe and locally aggressive condition that histopathologically resembles a necrotizing soft tissue infection. As opposed to necrotizing soft tissue infections, NSS responds to systemic steroids. SS is divided into three subtypes: classical SS, malignancy-associated SS, and drug-induced SS. Within the malignancy-associated SS subtype, both solid tumor and hematologic malignancies have been precurs...
Source: Case Reports in Dermatology - November 7, 2022 Category: Dermatology Source Type: research
Calcium Electroporation for Management of Cutaneous Metastases in HER2-Positive Breast Cancer: A Case Report
We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years. CaEP is performed in local or general anesthesia, by injecting calcium chloride intratumorally and then electroporating cells in the area. Using a handheld needle electrode, a series of short, high-voltage electric pulses are delivered, which transiently permeabilizes cell membranes, causing toxic intracellular calcium levels. The treatment causes cancer cell death, while normal cells are less affected, making the treatment useful for loca...
Source: Case Reports in Dermatology - November 4, 2022 Category: Dermatology Source Type: research
Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
We present the case of a patient with severe GPP, at first unsuccessfully treated with cyclosporine. We chose to treat the patient with ixekizumab, an anti-IL-17 antibody known for its rapid action in psoriasis vulgaris, that has also been reported as effective in GPP. The patient improved rapidly, with resolution of the active lesions after the first administration. The treatment has been continued for 2 years, with no adverse events and sustained disease control. Ixekizumab could be considered a safe and effective option in patients with GPP.Case Rep Dermatol 2022;14:326 –329 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 4, 2022 Category: Dermatology Source Type: research
Subcutaneous Panniculitis-like T-Cell Lymphoma with a Transformation to Lupus Erythematosus Panniculitis: A Case Report
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma characterized by infiltration of the subcutaneous tissue by neoplastic cytotoxic T cells mimicking panniculitis. There is a strong association between SPTCL and lupus erythematosus panniculitis (LEP). However, patients who were diagnosed with LEP with a preceding diagnosis of SPTCL have been scarcely reported. We herein reported a 21-year-old Thai woman presenting to a dermatology clinic for evaluation of a 1-month history of a painful mass on the right buttock and bilateral upper eyelid swelling. A subcutaneous mass which was 5 by ...
Source: Case Reports in Dermatology - November 4, 2022 Category: Dermatology Source Type: research
An Unusual Presentation of Merkel Cell Carcinoma in the Setting of Immunosuppression on TNF-Alpha Inhibitor Therapy
Merkel cell carcinoma (MCC) is a rare but deadly skin cancer, observed classically in the sun-damaged skin of older, white males. The cancer is characterized by rapid growth as well as high morbidity and mortality. In this article, we detail an atypical presentation of MCC in an African-American patient being treated with prednisone, methotrexate, and adalimumab for rheumatoid arthritis. Initially presenting as a subcutaneous nodule, the tumor in our patient was misdiagnosed first as an abscess and treated accordingly. Only after the subcutaneous mass failed to resolve with antibiotics as well as repeated incision and drai...
Source: Case Reports in Dermatology - November 4, 2022 Category: Dermatology Source Type: research
Acrokeratosis Paraneoplastica (Bazex Syndrome): A Case Report
Acrokeratosis paraneoplastica Bazex is a rare paraneoplastic skin manifestation, typically causing acral psoriasiform lesions. Patients usually show erythematous hyperkeratosis with yellowish, adherent scales on the hands and feet or other acral locations such as ears or nose. We herein report a case of Bazex syndrome in a male patient, who was previously diagnosed with hepatocellular carcinoma. Our case report highlights this rare condition as early diagnosis may impact the patient ’s course of tumor disease and prognosis.Case Rep Dermatol 2022;14:307 –312 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - October 20, 2022 Category: Dermatology Source Type: research
Tocilizumab-Induced Erythema Annulare Centrifugum
We report the case of a 42-year-old woman with rheumatoid arthritis undergoing treatment with subcutaneous tocilizumab for the past 6 months. Three days after the administration, an asymptomatic inflammatory annular plaque of 4 cm with discrete whitish scales at the inner border margin developed at the injection site in the left iliac fossa. A smaller plaque in the left groin appeared soon after. The mycological exam was negative. Histology showed a lymphoplasmacytic superficial and deep perivascular, and periadnexal, dermal infiltrate, without epidermal changes. Lesions spontaneously regressed in 4 months. The diagnosis w...
Source: Case Reports in Dermatology - October 13, 2022 Category: Dermatology Source Type: research
Acute Disseminated Panniculitis Associated with Alpha-1 Antitrypsin Deficiency
Alpha-1 antitrypsin deficiency, although one of the most common genetic diseases, is a very rare and often undiagnosed cause of panniculitis. The authors present a case characterized by an acute involvement of several areas in the thorax, abdomen, and limbs, occurring after repetitive trauma of the perineal area caused by a long period of cycling. After performing the differential diagnosis and establishing etiology, the patient was started on augmentation therapy with plasma-derived synthetic human alpha-1 proteinase inhibitor and the disease has been under control since then. We recommend lifelong treatment with this med...
Source: Case Reports in Dermatology - October 6, 2022 Category: Dermatology Source Type: research
Epidermolysis Bullosa and Rickets in a 21-Year-Old Female: A Case Report
Epidermolysis bullosa (EB) is a group of rare genetic diseases that exhibit mechanical fragility of the skin. This condition will result in the occurrence of skin blisters, skin erosions, and skin ulcerations when the skin is subjected to trauma. In this case report, we present a case of EB and multiple skeletal deformities in a 21-year-old female. She came to our clinic with recurrent skin exfoliations and blisters that occurred since she was 4 years old and multiple bones bowing since she was 9 years old. On physical examinations, we found generalized hypopigmentation macule with erythematous skin. There were numerous bu...
Source: Case Reports in Dermatology - October 6, 2022 Category: Dermatology Source Type: research
Treatment of Condylomata Acuminata Using a New Non-Vapor-Generating Focused Ultrasound Method following Imiquimod 5% Cream
Condylomata acuminata is the most common sexually transmitted disease in the world. Physical treatments include excision, cryotherapy, electrocautery and ablative CO2, and Nd:YAG laser ablation, while topical treatments include imiquimod immunotherapy and antimitotic podophyllotoxin or sinecatechins. Efficacies of all methods are low, and recurrences are very common. A new combined method is presented as a single case in a 25-year-old male patient diagnosed with numerous condylomas on the penis, scrotum, and lower abdomen. The treatment consisted of a 7-week topical monotherapy using 5% imiquimod cream followed by local tr...
Source: Case Reports in Dermatology - October 4, 2022 Category: Dermatology Source Type: research
Successful Novel Treatment of Nonuremic Calciphylaxis with Sodium Thiosulfate and Iloprost: A Case Report
Calciphylaxis is a rare and potentially life-threatening disease which occurs most frequently in end-stage renal disease. Here, we describe a 69-year-old male patient who presented to the clinic with extremely painful necrotic ulcers of the right lower extremity. His risk factors included hypertension, diabetes mellitus type II, steatosis hepatis, and chronic hepatitis B. Laboratory studies revealed no signs for uremia, hyperparathyroidism, and normal phosphorus as well as calcium levels. A diagnosis of nonuremic calciphylaxis was made in correlation with clinical and histological features. A novel therapeutic approach com...
Source: Case Reports in Dermatology - September 19, 2022 Category: Dermatology Source Type: research
Acoustic Wave Therapy for the Treatment of Extensive Scar Fields: A Case Report
We report a severe scalding case with an affected skin area of 30 –40% of the body surface. The patient suffered from severe itching and pain in the hypertrophic scar parts even 1.5 years after the accident. Treatment with acoustic wave therapy almost daily during the first treatment cycle was able to significantly reduce the discomfort. On representation after 1 year, the skin condition showed significant improvement. The second treatment cycle brought further improvement. At the last check-up 2 years later, the patient was free of complaints.Case Rep Dermatol 2022;14:264 –268 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 16, 2022 Category: Dermatology Source Type: research
Six Cases of Erythrodermic Pemphigus Foliaceus: A Case Report
Pemphigus foliaceus (PF) is one of the causes of erythroderma; however, to date, there have been relatively few reported cases. We herein describe 6 cases of erythrodermic PF. In all 6 cases, PF was a direct cause of erythroderma because the patients had not undergone any medical treatments and neither had any other skin diseases nor were taking any drugs that typically cause erythroderma. Serum levels of IgE and thymus and activation-regulated chemokine were elevated in 5 of the 6 cases, whereas soluble interleukin-2 receptor and squamous cell carcinoma-related antigen were markedly increased in all cases, suggesting that...
Source: Case Reports in Dermatology - September 5, 2022 Category: Dermatology Source Type: research
Persistent Facial Blanching after Botulinum Toxin Injection
We report the case of a 38-year-old male patient who presented with blanching of the face after strenuous exercise or physical exertion. The symptoms regressed in a relaxed state. Three years before presentation, he underwent botulinum toxin injections in the affected areas of the face. Facial blanching is a rare side effect of botulinum toxin injection. The postulated pathophysiology involves different transmitters mainly acetylcholine as well as co-transmitters implicated in vasodilation. Usually, facial blanching resolves shortly after waning of the botulinum toxin. However, in our case, the symptoms persisted for a lon...
Source: Case Reports in Dermatology - August 31, 2022 Category: Dermatology Source Type: research
A Case of Verrucous Carcinoma Treated by Combination of Radiotherapy and Mohs ’ Chemosurgery
We present a rare case of VC that could be treated with combined radiotherapy and Mohs ’ chemosurgery, as a new option for unresectable VC.Case Rep Dermatol 2022;14:250 –253 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 31, 2022 Category: Dermatology Source Type: research
