Widespread Hypertrophic Lichen Planus following Programmed Cell Death Ligand 1 Blockade
Hypertrophic lichen planus (HLP) may not have the typical histological findings of lichen planus and often mimics squamous cell carcinoma (SCC). Distinguishing between the two can pose a diagnostic challenge. Here, we present a case of eruptive HLP mimicking SCC in the context of programmed cell death ligand 1 (PD-L1) immune checkpoint inhibition. A 73-year-old woman recently treated with durvalumab, an anti-PD-L1 antibody, presented to our clinic with diffuse hyperkeratotic papules and plaques previously thought to be eruptive SCC. The lesions did not respond to topical fluorouracil and continued to appear despite discont...
Source: Case Reports in Dermatology - June 18, 2020 Category: Dermatology Source Type: research
A Case of Pincer Nail Successfully Treated with Tazarotene 0.1% Gel
Pincer nail is a common condition characterized by excessive transverse nail curvature, progressively pinching the nail bed distally, resulting in cosmetic discomfort, pain and functional limitation. Treatment is difficult and often unsatisfactory. Surgical treatment performed by experienced physicians provides good outcomes. However, patients usually hesitate to undergo invasive procedures, preferring conservative treatments. Unfortunately, these mainly offer only temporary relief and recurrence rate is high. Topical tazarotene has been used in several nail conditions, but its potential remains not fully elucidated. We he...
Source: Case Reports in Dermatology - May 18, 2020 Category: Dermatology Source Type: research
Extramammary Paget ’s Disease and Melanoma: 2 Cases of Double Cancers
Extramammary Paget ’s disease (EMPD) is a rare intraepidermal neoplastic disease. There is a well-known relationship between EMPD and underlying malignancy. However, only a few cases of EMPD and cutaneous melanoma have been reported previously. In this case report we present 2 cases of such double cancers: one as a collision tumor, the other at separate sites. We discuss the pathogenesis, treatment, and importance of a thorough clinical and radiological examination and review the literature.Case Rep Dermatol 2020;12:107 –113 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - May 18, 2020 Category: Dermatology Source Type: research
Reflectance Confocal Microscopy of Pigmented Bowen ’s Disease: A Case Series of Difficult to Diagnose Lesions
Pigmented Bowen ’s disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. The best-characterized feature of the disease by histological examination is the presence of atypical keratinocytes, hyperpigmentation of the epidermis with trans-epidermal elimination of melanin and dermal melanophages. Precise diagnosis is often difficult, both clinically and dermoscopically, as Bowen’s disease is often mistaken with keratinocyte tumors s uch as solar ...
Source: Case Reports in Dermatology - May 15, 2020 Category: Dermatology Source Type: research
A Case of Dermatomyositis Coexisting with Both Anti-Mi-2 and Anti-NXP-2 Antibodies
Myositis-specific autoantibodies (MSAs) including anti-Mi-2 and anti-nuclear matrix protein 2 (NXP-2) antibodies have been detected in the patients with dermatomyositis (DM), and are useful tools for identifying clinical subsets of DM. MSAs are exclusively found in DM patients. Anti-Mi-2 antibody-positive DM patients show the typical skin lesions and myositis and are rarely associated with internal malignancy and interstitial lung disease (ILD). On the other hand, adult DM patients with anti-NXP-2 antibody often show calcinosis and internal malignancy, but rarely ILD. In addition, anti-NXP-2 antibody-positive DM patients h...
Source: Case Reports in Dermatology - May 5, 2020 Category: Dermatology Source Type: research
Atypical Clinical Presentation of Hidradenitis Suppurativa in a Patient with Severe Mannose-Binding Lectin Deficiency
Mannose-binding lectin (MBL) deficiency is associated with recurrent infections, autoimmune and inflammatory skin disease, and vascular complications. MBL deficiency is not a recognized comorbidity in hidradenitis suppurativa (HS); the latter is associated with the group of autoinflammatory disorders. A 32-year-old woman presented with a history of recurrent painful, deep-seated abscesses and pustular lesions since the age of 13 years. Lesions were noted predominantly in HS distribution, i.e., submammary, inguinal, and perianal areas were affected. However, unusual locations (jawlines, neck) were also affected. The patient...
Source: Case Reports in Dermatology - May 5, 2020 Category: Dermatology Source Type: research
Exfoliative Erythroderma: An Unusual Presentation of Paraneoplastic Pemphigus Associated with Castleman ’s Disease
We report a 23-year-old woman who presented with generalized scaly erythematous rash predominately on the upper trunk and hemorrhagic stomatitis. The histopathologic and immunopathologic findings were consistent with the diagnosis of paraneoplastic pemphigus. Castleman ’s tumor was diagnosed with computed tomography and exploratory laparotomy. A partial clinical improvement was observed after complete tumor removal and intravenous immunoglobulin administration. However, the patient died as a result of septicemia.Case Rep Dermatol 2020;12:76 –81 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 14, 2020 Category: Dermatology Source Type: research
Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report
We present a rare case of a patient with SpSCC in the gluteal region with regional lymph node metastasis. The patient was treated with wide excision of the tumor, inguinal lymph node dissection, and adjuvant radiotherapy. Cutaneous SpSCC is clinically similar to conventional SCC but can demonstrate more aggressive behavior. This case is rare since it was localized in the gluteal region of an otherwise healthy man.Case Rep Dermatol 2020;12:70 –75 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 8, 2020 Category: Dermatology Source Type: research
Netherton ’s Syndrome: A Case of Two Male Siblings Diagnosed in Adulthood
Netherton ’s syndrome (NS) is a rare autosomal recessive genetic disease caused by a germline mutation in the SPINK5 gene. It is most commonly diagnosed in neonates due to the presence of congenital ichthyosiform erythroderma. Affected individuals will typically also develop a hair shaft abnormality known a s trichorrhexis invaginata, severe atopy, and a migratory rash known as ichythyosis linearis circumflexa. The chronicity and severity of NS adversely affects a patient’s quality of life to a large extent. It Is therefore important that this condition is identified early, and treatment to reduce cu taneous inflammati...
Source: Case Reports in Dermatology - April 8, 2020 Category: Dermatology Source Type: research
Prelims
Case Rep Dermatol 2019;11:I –IV (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 25, 2020 Category: Dermatology Source Type: research
A Case of Loose Anagen Hair Syndrome in a Southeast Asian Boy
We report the case of a 13-year-old Thai boy who presented with a single patch of hair thinning on the frontal scalp with excessive shedding, and the hairs did not grow long. Microscopic examination showed naked anagen bulbs with ruffling of the cuticle, which is compatible with loose anagen hair syndrome. To our knowledge, there is no reported case in Southeast Asian children.Case Rep Dermatol 2019;11:204 –208 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - July 3, 2019 Category: Dermatology Source Type: research
< b > < i > Trichophyton erinacei < /i > < /b > Onychomycosis: The First to Evidence a Proximal Subungual Onychomycosis Pattern
We describe the case of a 23-year-old Thai female who had a history of systemic lupus erythematosus with lupus nephritis type III and who developed widespread skin and nail infections caused byT. erinacei that were most likely transmitted from a hedgehog. Although the patient did not demonstrate a clinical improvement or mycological cure following systemic itraconazole and fluconazole treatment, she achieved clinical and mycological cures after terbinafine therapy. A drug susceptibility test should be performed in patients withT. erinacei infections to facilitate decision-making about antifungal therapy. Here, we are the f...
Source: Case Reports in Dermatology - July 2, 2019 Category: Dermatology Source Type: research
Mosquito Bite-Induced Localized NK/T-Cell Lymphoma Relapsed in a Patient with Complete Remission of Extranodal NK/T-Cell Lymphoma, Nasal Type
We report a rare case of localized NK/T-cell lymphoma following a mosquito bite after achieving complete response of extranodal NK/T-cell lymphoma, nasal type (ENKL). T cells and NK cells infected by Epstein-Barr virus (EBV) lead to NK/T-cell lymphoma, including ENKL. Lymphoma related to mosquito bites usually requires a prolonged treatment course, and the disease onset of hypersensitivity begins in early childhood. In the current case, the patient had no history of hypersensitivity to mosquito bites. We speculate that the latently EBV-infected NK/T cells in the blood were reactivated by mosquito gland antigens, expanded a...
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research
Severe Infantile Bullous Pemphigoid Treated with Dapsone after Bridging with Systemic Glucocorticoid
We present a case of severe and treatment-refractory bullous pemphigoid in a 3-month-old child. After topical and systemic corticoid treatment proved inefficient, dapsone 0.75 mg/kg was added initially without success. Disease control was reached with dapsone 1.5 mg/kg in addition to both topical and systemic glucocorticoid treatment, leaving the child with several side effects of the glucocorticoid treatment.Case Rep Dermatol 2019;11:187 –193 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research
Localized Hypertrichosis with Traumatic Panniculitis: A Case Report and Literature Review
Localized hypertrichosis with traumatic panniculitis is considered a rare condition. Previous articles have reported occurrence in females aged between 20 and 35 years. Possible mechanisms of trauma-induced localized hypertrichosis include hyperemia and angiogenesis induced by local inflammation, which can alter the hair growth cycle. The presence of inflammatory cells and lipomembranous changes on histopathology can support the diagnosis. We herein present a 35-year-old female patient with localized hypertrichosis following blunt trauma.Case Rep Dermatol 2019;11:180 –186 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research
