A Case of Extensive Grover ’s Disease in a Patient with a History of Multiple Non-Melanoma Skin Cancers
We report on a 69-year-old man who presented with itching and erythematous papules on his torso and extremities, which were resistant to topical therapy with antibiotics and steroids. Physical examination revealed multiple erythematous papules on his back, neckline, and lower extremities. The lesions had appeared 4 years earlier and usually worsened with heat or extensive sweating. Histopathology of previous skin biopsies had shown multiple cutaneous squamous cell carcinomas or was non-conclusive. Thus, a re-biopsy was performed, revealing acanthosis and focal acantholytic dyskeratosis. These clinical and anamnestic findin...
Source: Case Reports in Dermatology - December 7, 2021 Category: Dermatology Source Type: research
Necrobiosis Lipoidica: Atypical Presentation in a Diabetic Girl
We report a case of type 1 diabetic 13-year-old girl who developed yellow atrophic plaque with telangiectasia on the extensor aspect of her upper arm.Case Rep Dermatol 2021;13:547 –552 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 30, 2021 Category: Dermatology Source Type: research
Squamous Cell Carcinoma as a Complication of Long-Term Hydroxyurea Treatment
We report a 56-year-old man with a 13-year history of polycythemia vera, treated chronically with hydroxyurea. In April 2020, the patient presented a skin lesion on the forehead, skin horn on the left forearm, and hyperkeratosis on the rims of both ears. In the patient ’s history, in October 2019, complete excision of the skin lesion in the central area of the forehead was performed. After 4 months, a new skin lesion appeared at the same area of the forehead, which in May 2020 after resection in the histopathological examination was diagnosed as recurrence of sq uamous cell carcinoma. The aim of the case is to draw the c...
Source: Case Reports in Dermatology - November 30, 2021 Category: Dermatology Source Type: research
Intravascular Basal Cell Carcinoma Hiding under a Keratoacanthoma
A 79-year-old male presented for removal of what was proven to be a keratoacanthoma. Additional tissue removed deep to the initial lesion revealed intravascular basal cell carcinoma (BCC). Intravascular BCC is exceedingly rare with only 8 cases previously reported in the literature. Intravascular BCC may be associated with more aggressive subtypes. Intravascular infiltration is more common in metastatic BCC, but this finding may not imply causality. More data are required in order to determine prognostic implications of intravascular BCC and to develop a protocol for managing patients with this unique finding.Case Rep Derm...
Source: Case Reports in Dermatology - November 29, 2021 Category: Dermatology Source Type: research
Follicular Dowling-Degos Disease with Hidradenitis Suppurativa: A Case Report and Review of the Literature
Dowling-Degos disease (DDD) is an autosomal dominant disorder with variable phenotypic expression. Classically, DDD is characterized by progressive reticulate hyperpigmentation on flexures with perioral pitted scars and comedone-like hyperkeratotic papules. Follicular DDD is a rare variant which was introduced by Singh et al. [Indian J Dermatol Venereol Leprol. 2013 Nov –Dec;79(6):802–4]. Follicular DDD differs from other variants because of its notable comedone-like hyperkeratotic hyperpigmented papules and a distinct histopathology which demonstrates pigmented filiform and branching rete pegs originating at the folli...
Source: Case Reports in Dermatology - November 29, 2021 Category: Dermatology Source Type: research
An Extensive Case of Merkel Cell Carcinoma due to Fright of COVID-19
We present a case report of a 74-year-old female, who had noticed a rapidly growing, oozing tumor on her right flank. She was hesitant to contact the dermatology ward where she had regular checkups as she was afraid of contracting COVID-19. This was in the beginning of the COVID-19 pandemic. At presentation, she had a large exophytic MCC on her right flank and multiple metastases. The disease was at a late stage, and palliative care was the only treatment option left. With this case, we wish to report a rather uncharacteristic location and size of an MCC tumor and suggest that fear of the pandemic and the COVID-19 lockdown...
Source: Case Reports in Dermatology - November 25, 2021 Category: Dermatology Source Type: research
A Case Report of Vitiligo Induced by Alexandrite Hair Removal Laser
Vitiligo is one of the disorders where we usually see Koebner lesions. Lasers target a chromophore in the skin to deliver their energy. Their effect is theoretically considered as injury and may induce Koebner lesions in vitiligo patients. Few cases were reported with the different kinds of laser, including laser hair removal (LHR). No cases have ever been reported of vitiligo lesions induced by Alexandrite LHR. Here we present a case report of a young female patient who had never had vitiligo until she received a 755-nm LHR treatment. These vitiligo lesions were completely treated with NB-UVB with no recurrence until 4 ye...
Source: Case Reports in Dermatology - November 23, 2021 Category: Dermatology Source Type: research
Tattoo-Associated Cutaneous < b > < i > Mycobacterium mageritense < /i > < /b > Infection: A Case Report and Brief Review of the Literature
We present a case of tattoo-associated cutaneous infection caused byMycobacterium mageritense, a rare species of rapidly growing NTM. A 25-year-old man developed a rash on his left lower leg 4 weeks after he underwent professional tattooing. A skin swab identifiedM.mageritense complex. Based on susceptibility testing, a course of oral ciprofloxacin and trimethoprim/sulfamethoxazole was initiated, with significant improvement observed after 5 weeks. We speculate that the mechanism of inoculation was a result of either the artist using nonsterile water to dilute black ink to gray or from use of contaminated prediluted gray i...
Source: Case Reports in Dermatology - November 23, 2021 Category: Dermatology Source Type: research
Activation of the Hedgehog and Wnt/ β-Catenin Signaling Pathways in Basal Cell Carcinoma
In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/ β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated. Here, a case of sporadic BCC in an 80-year-old man is presented, and the effectiveness of SMO inhibitors in case of relapse is predicted. The aim of this study was to determine whether the SMO inhibitors can be effective in treating this individual should the tumor recur in the future. Immunohistochemistry (IHC) was performed in a tumor and the adjacent skin tissue from the patient. IHC within the same BCC tissue specimen revealed that Glioma-assoc...
Source: Case Reports in Dermatology - November 16, 2021 Category: Dermatology Source Type: research
A Peculiar Case of Large and “Unresectable” Primary Localized Cutaneous Nodular Amyloidosis of the Ankle
We report a case of a large primary nodular cutaneous amyloidosis of the leg involving the joint capsule which was successfully treated by incomplete surgical removal, without recurrences at 7-year follow-up.Case Rep Dermatol 2021;13:502 –505 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - October 21, 2021 Category: Dermatology Source Type: research
Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor- α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report present s a case of in...
Source: Case Reports in Dermatology - October 21, 2021 Category: Dermatology Source Type: research
The Review of the Difference between Patients and Physicians in Terms of Severity Assessment and Therapeutic Goals in Androgenetic Alopecia in Japan
We often come across differences in the severity of androgenetic alopecia (AGA) as assessed subjectively by the patients themselves and objectively by the attending physicians. For the purpose of examining the differences in the assessment of AGA between patients and physicians, we presented the Norwood classification to male patients and the Shiseido classification to female patients and asked them to assess the degree of hair loss by themselves. We compared the results with the severity as assessed by 2 specified dermatologists. The results show that the assessments of the severity of AGA were consistent between the pati...
Source: Case Reports in Dermatology - October 11, 2021 Category: Dermatology Source Type: research
Pembrolizumab-Induced Lichen Planus on the Scalp of a Patient with Non-Small-Cell Lung Carcinoma
A 67-year-old man with non-small-cell lung carcinoma was referred to our department because of a pruritic rash on his head and upper extremities. Prior to the development of the rash, he had received 4 cycles of combination therapy with pemetrexed, carboplatin, and pembrolizumab, followed by 2 cycles of pembrolizumab monotherapy. On physical examination, violaceous scaly erythema grouped on his scalp and upper extremities. Histologically, the scalp lesions demonstrated irregular acanthosis that formed a characteristic saw-tooth appearance with hypergranulosis and typical lichenoid tissue reaction. These findings suggested ...
Source: Case Reports in Dermatology - October 8, 2021 Category: Dermatology Source Type: research
Retraction: “Perforating Granuloma Annulare Appearing as a Psoriasiform Lesion”
Case Rep Dermatol 2021;13:486 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - September 30, 2021 Category: Dermatology Source Type: research
Cutaneous Features of Anti-MDA-5 Antibody-Positive Amyopathic Dermatomyositis in a Sudanese Patient
Clinically amyopathic dermatomyositis (CADM) is a rare form of DM characterized by unique cutaneous and pulmonary features with no muscle involvement. A subset of patients with CADM has a specific antibody known as anti-melanoma differentiation-associated protein 5 (MDA5). The systemic associations of anti-MDA-5 CADM warrant an early recognition and management to prevent fetal sequelae. It is seen more commonly in white and Asian female individuals. The clinical features of anti-MDA5 antibody-positive CADM in other ethnic groups are not well reported. Here, we describe a case of CADM with identified autoantibodies against ...
Source: Case Reports in Dermatology - September 28, 2021 Category: Dermatology Source Type: research
